[1]李晓凤,庄羽翔,傅浪舟,等.能谱CT容积定量参数鉴别结直肠癌病理类型的价值[J].陆军军医大学学报(原第三军医大学学报),2022,44(18):1881-1886.
　LI Xiaofeng,ZHUANG Yuxiang,FU Langzhou,et al.Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer[J].J Amry Med Univ (J Third Mil Med Univ),2022,44(18):1881-1886.
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
44卷
期数:
2022年第18期
页码:
1881-1886
栏目:
临床医学
出版日期:
2022-09-30

文章信息/Info

Title:
Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer
作者:
李晓凤; 庄羽翔; 傅浪舟; 刘巧; 周代全; 旷连勤; 曾燕
重庆医科大学附属第三医院放射科
Author(s):
LI Xiaofeng;  ZHUANG Yuxiang;  FU Langzhou;  LIU Qiao;  ZHOU Daiquan;  KUANG Lianqin;  ZENG Yan
Department of Radiology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China
 
关键词:
结直肠癌; 黏液腺癌; 管状腺癌; 能谱CT
Keywords:
colorectal cancer;  mucinous adenocarcinoma;  tubular adenocarcinoma;  energy spectrum CT
分类号:
R735.35; R814.3; R814.42
文献标志码:
A
摘要:

目的探讨能谱CT容积定量参数对鉴别结直肠癌病理类型的临床价值。方法回顾性分析2019年1月至2021年11月在本院经病理证实的66例结直肠癌患者的临床和影像学资料，其中黏液腺癌16例，管状腺癌50例，采用不同的感兴趣区域(region of interest, ROI)获取方法测得肿瘤的容积参数和二维参数，包括碘(水)浓度、水(碘)浓度、有效原子序数，并计算出标准化碘（水）浓度（normalized iodine concentration，NIC）。采用t检验或Mann-Whitney U检验进行组间比较，对有统计学意义的参数运用 ROC 曲线评价其对结直肠癌病理类型的诊断效能。结果能谱CT容积参数中，动脉期和静脉期的碘（水）浓度、NIC、有效原子序数组间差异均具有统计学意义（P<0.01）；黏液腺癌的碘（水）浓度、NIC、有效原子序数均低于管状腺癌。而在二维参数中，仅静脉期的碘（水）浓度、NIC、有效原子序数组间差异具有统计学意义（P<0.05）。黏液腺癌的容积碘（水）浓度和NIC低于相应二维参数。ROC曲线显示容积参数的曲线下面积均高于二维参数，其中动脉期容积NIC的诊断效能最高，其敏感度为82.0%，特异度为87.5%。结论能谱CT容积定量参数对鉴别结直肠黏液腺癌和管状腺癌较二维参数可能具有更大的潜在临床价值。

Abstract:

ObjectiveTo investigate the clinical value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer. MethodsThe clinical and imaging data of 66 patients (16 cases of mucinous adenocarcinoma and 50 cases of tubular adenocarcinoma) with colorectal cancer confirmed by pathology in our hospital from January 2019 to November 2021 were collected and retrospectively analyzed. The volume parameters and two-dimensional parameters of the tumor, including iodine (water) concentration, water (iodine) concentration and effective atomic number, were measured by different methods of region of interest (ROI) acquisition, and normalized iodine (water) concentration (NIC) was calculated. Student’s t test or Mann-Whitney U test was used for comparison between groups, and receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of statistically significant parameters for pathological types of colorectal cancer. ResultsIn terms of energy spectrum volume parameters, iodine (water) concentration, NIC and Eff-Z in arterial and venous phases were significantly different (P<0.01). The iodine (water) concentration, NIC and Eff-Z of mucinous adenocarcinoma were lower than those of tubular adenocarcinoma. However, in the two-dimensional parameters, only iodine (water) concentration, NIC and Eff-Z in venous phase had significant differences among groups (P<0.05). The volumetric iodine (water) concentration and NIC in mucinous adenocarcinoma were lower than corresponding two-dimensional parameters. ROC curve showed that the area under the curve of energy spectrum volume parameters was higher than that of two-dimensional parameters. Among them, arterial volume NIC had the highest diagnostic efficiency, with a sensitivity of 82.0% and specificity of 87.5%. ConclusionThe quantitative parameters of CT volume of energy spectrum may have greater potential clinical value in differentiating mucinous colorectal adenocarcinoma from tubular adenocarcinoma than two-dimensional parameters. 

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更新日期/Last Update: 2022-09-23