[1]马嘉雪,张琴,曾晓娟,等.心房颤动患者的生活质量及其影响因素分析[J].陆军军医大学学报(原第三军医大学学报),2022,44(18):1835-1844.
　MA Jiaxue,ZHANG Qin,ZENG Xiaojuan,et al.Quality of life and its influencing factors in patients with atrial fibrillation[J].J Amry Med Univ (J Third Mil Med Univ),2022,44(18):1835-1844.
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心房颤动患者的生活质量及其影响因素分析(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
44卷
期数:
2022年第18期
页码:
1835-1844
栏目:
临床医学
出版日期:
2022-09-30

文章信息/Info

Title:
Quality of life and its influencing factors in patients with atrial fibrillation
作者:
马嘉雪; 张琴; 曾晓娟; 邬娜; 袁志权; 李成英; 吴龙; 陈彦秀; 许祥; 仝识非; 李亚斐; 张志辉; 钟理
重庆医科大学附属第三医院心血管内科；陆军军医大学（第三军医大学）：军事预防医学系军队流行病学教研室，第一附属医院心血管内科3
Author(s):
MA Jiaxue1;  ZHANG Qin1;  ZENG Xiaojuan1;  WU Na2;  YUAN Zhiquan2;  LI Chengying2;  WU Long2;  CHEN Yanxiu3;  XU Xiang3;  TONG Shifei1;  LI Yafei2;  ZHANG Zhihui3;  ZHONG Li1
1Department for Cardiovascular Diseases, the Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120; 2Department of Epidemiology, Faculty of Military Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038; 3Department of Cardiology, First Affiliated Hospital, Army Medical University  (Third Military Medical University), Chongqing, 400038, China
 
关键词:
心房颤动; 生活质量; 影响因素; 房颤生活质量量表
Keywords:
atrial fibrillation;  quality of life;  influencing factors;  quality of life for atrial fibrillation patients
分类号:
R195.4; R492; R541.75
文献标志码:
A
摘要:

目的调查心房颤动（简称房颤）患者的生活质量，探讨影响房颤患者生活质量的相关因素。方法采用房颤患者特异性汉化版房颤生活质量量表（Atrial Fibrillation Effect on Quality-of-Life，AFEQT），对2016年6月至2021年3月在两所三甲医院心血管内科就诊的非瓣膜性房颤患者进行生活质量调查，采用多因素logistic回归分析与房颤患者生活质量相关的因素。结果共调查321例房颤患者。房颤患者生活质量的总分中位数M（四分位数P25，P75）为79.86（70.25，89.81）。针对生活质量不同维度的多因素logistic回归分析发现，吸烟史、升高的凝血酶时间（thrombin time， TT)、总蛋白（total protein，TP）和D-二聚体（D-dimer）水平是症状维度的危险因素，而有甲状腺功能障碍史则是保护因素；日常活动维度的危险因素包括高龄（≥65岁）、高血压病史、脑卒中病史、华法林药物史以及升高的TT，而饮酒可能是保护因素；有高血压病史，华法林、他汀药物史以及单核细胞（monocytes，MONO）水平和凝血酶原时间（prothrombin time， PT）升高的房颤患者的治疗担心维度评分显著下降，而活化部分凝血活酶时间比值（activated partial thromboplastin time ratio， APTT-ratio)升高是治疗担心维度评分的保护因素；延长的TT是治疗满意维度评分下降的危险因素，而有新型口服抗凝（novel oral anticoagulants， NOACs）药物史以及APTT-ratio升高是治疗满意维度评分下降的保护因素；生活质量总分下降的危险因素包括高龄（≥75岁）、脑卒中史、华法林和他汀药物史以及D-dimer水平，而饮酒以及较高的中性粒细胞（neutrophil，NEU)水平则是其保护因素。结论高龄（≥65岁）、吸烟史、华法林和他汀类药物史、高血压和脑卒中病史、升高的MONO、TP、TT、PT以及D-dimer水平等多种因素影响房颤患者生活质量的不同维度。

Abstract:

ObjectiveTo explore the quality of life and its influencing factors in patients with atrial fibrillation (AF). MethodsThe Chinese Atrial Fibrillation Effect on Quality-of-Life(AFEQT) questionnaire was used to investigate the quality of life in AF patients who had been treated in the Department of Cardiovascular Diseases of 2 tertiary Class A hospitals from June 2016 to March 2021. Multivariate logistic regression model was used to analyze the factors related to the quality of life in the patients. ResultsA total of 321 AF patients were investigated. The median of total score for quality of life was 79.86 (interquartile range: 70.25, 89.81) in the AF patients. Multivariate logistic regression analysis on different dimensions of quality of life found that smoking history, elevated thrombin time (TT), total protein and D-dimer levels were risk factors in the symptom dimension, while a history of thyroid dysfunction was a protective factor; risk factors in the daily activity dimension included advanced age (≥65 years), hypertension history, stroke history, history of warfarin use, and prolonged TT, while alcohol consumption may be protective factors; the patients with history of hypertension, warfarin and statin use, and elevated monocyte (MONO) count and prolonged prothrombin time (PT) had significantly lower scores in the dimension of treatment of worried, while an activated partial thromboplastin time ratio (APTT-ratio) was a protective factor in the treatment of the worry score; prolonged TT was a risk factor for decreased treatment satisfaction scores; a history of novel oral anticoagulants (NOACs) and elevated APTT-ratio were protective factors for decreased treatment satisfaction scores; risk factors for decreased overall quality of life scores included advanced age (≥75 years), history of stroke, warfarin and statin use, and D-dimer level, while alcohol consumption and higher neutrophil count were protective factors. ConclusionAdvanced age (≥65 years), smoking history, warfarin and statin history, hypertension, stroke history, elevated MONO, TP, TT, PT, and D-dimer level affect quality of life in AF patients in different dimensions. 

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更新日期/Last Update: 2022-09-23