[1]王宽,詹彦,蒋理,等.丘脑底核脑深部电刺激术治疗伴有异动的帕金森病的疗效分析[J].第三军医大学学报,2020,42(24):2426-2432.
 WANG Kuan,ZHAN Yan,JIANG Li,et al.Efficacy of subthalamic deep brain stimulation for levodopa-induced dyskinesia in patients with Parkinson’s disease: retrospective analysis of 12 cases[J].J Third Mil Med Univ,2020,42(24):2426-2432.
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丘脑底核脑深部电刺激术治疗伴有异动的帕金森病的疗效分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第24期
页码:
2426-2432
栏目:
临床医学
出版日期:
2020-12-30

文章信息/Info

Title:
Efficacy of subthalamic deep brain stimulation for levodopa-induced dyskinesia in patients with Parkinson’s disease: retrospective analysis of 12 cases
作者:
王宽詹彦蒋理黄加尚向怡石全红谢延风
重庆医科大学附属第一医院神经外科
Author(s):
WANG Kuan ZHAN Yan JIANG Li HUANG Jiashang XIANG Yi SHI Quanhong XIE Yanfeng

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

关键词:
 
Keywords:
 
分类号:
R651.1;R742.5
文献标志码:
A
摘要:
帕金森病;脑深部电刺激术;左旋多巴诱导的异动症;丘脑底核;左旋多巴等效剂量
 
Abstract:
ObjectiveTo evaluate the clinical effectiveness of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease (PD), and to explore the feasibility and the possible underlying mechanism of the treatment. MethodsA retrospective review was conducted on all the PD patients who underwent STN-DBS in our department from March 2016 to December 2019. Unified Parkinson’s Disease Rating Scale (UPDRS) part Ⅲ and part Ⅳ, dyskinesia subscore (items 32 to 34 of UPDRS part Ⅳ) and the levodopa equivalent daily dose (LEDD),which were used to evaluate the improvement of the symptoms before and in 6 months after operation. ResultsIn 6 months after STN-DBS, the LID symptoms of the 12 patients finally enrolled were significantly improved, with the improvement rates of UPDRS Ⅳ score and dyskinesia subscore of (45.91±13.01)% and (61.96±22.03)%, respectively. Among them, the LEDD was maintained in 2 patients, and reduced in the other 10 patients, with the averagely reduced rate of 43.58%, and the highest rate of 72.00%. Meanwhile, the motor symptoms of all patients were also significantly improved, and the improvement rate of UPDRS Ⅲ score was (68.14±9.51)%. ConclusionSTN-DBS significantly improves dyskinesia symptom of PD patients. Its anti-dyskinesia effect may be not only related to reduction of drug dose, but also to direct inhibition of LID.
 

相似文献/References:

[1]向怡,蒋理,覃彬,等.帕金森病患者丘脑底核脑深部电刺激术中同期植入双侧电极精度及治疗效果的研究[J].第三军医大学学报,2020,42(05):517.
 XIANG Yi,JIANG Li,QIN Bin,et al.Precision of bilateral electrode implantation and treatment outcome in Parkinson’s disease after subthalamic nucleus deep brain stimulation[J].J Third Mil Med Univ,2020,42(24):517.

更新日期/Last Update: 2020-12-22