[1]胡钧浩,张偲,范卫杰,等.男性高尿酸血症患者静息态脑功能磁共振成像研究[J].第三军医大学学报,2020,42(14):1421-1427.
 HU Junhao,ZHANG Si,FAN Weijie,et al.Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging[J].J Third Mil Med Univ,2020,42(14):1421-1427.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第14期
页码:
1421-1427
栏目:
神经科学
出版日期:
2020-07-30

文章信息/Info

Title:
Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging
作者:
胡钧浩张偲范卫杰李光辉刘波文利王光宪张磊张冬
陆军军医大学(第三军医大学)第二附属医院放射科
 
Author(s):
HU Junhao ZHANG Si FAN Weijie LI Guanghui LIU Bo WEN Li WANG Guangxian ZHANG Lei ZHANG Dong

Department of Radiology, Second Affiliated Hospital, Army Medical University (Third Military Medical University),  Chongqing, 400037, China

关键词:
高尿酸血症尿酸静息态功能磁共振成像低频振幅功能连接
Keywords:
hyperuricemia uric acid resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuation functional connectivity
分类号:
R445.2; R589.7; R741
文献标志码:
A
摘要:

目的探讨男性高尿酸血症患者静息状态下脑功能变化情况,探索血尿酸(serum uric acid,SUA)升高引起患者情绪及认知改变的神经生物学机制。方法选取2019年1-12月经社区招募的未经药物治疗的男性高尿酸血症患者(高尿酸血症组)及健康对照(对照组)各41例,行空腹血尿酸检测、神经心理测试和静息态功能磁共振(resting-state functional magnetic resonance imaging,rs-fMRI)扫描。利用低频振幅(amplitude of low-frequency fluctuation,ALFF)方法找出两组之间存在活动差异的脑区,随后行基于种子点与全脑各体素间的功能连接(functional connectivity,FC)分析。结果与对照组比较,高尿酸血症组左颞下回ALFF值减低,双侧额下回ALFF升高。以左颞下回极值点设种子点,与双侧楔叶间的FC强度增强;以左额下回极值点设种子点,与左侧丘脑、右尾状核间的FC强度增强。血尿酸、神经心理及认知测试结果显示:血尿酸浓度与工作记忆反应时间呈正相关(r=0.320,P=0.041),工作记忆准确率与左侧颞下回中的ALFF值呈正相关(r=0.535,P<0.001),执行功能准确率与左侧及右额下回的ALFF值呈正相关(r=0.461,P=0.002;r=0.566,P<0.001),此外,左侧额下回与左侧丘脑及右侧尾状核之间FC强度分别与睡眠质量评分及贝克抑郁量表评分呈负相关(r=-0.361,P=0.020;r=-0.343,P=0.028)。结论男性高尿酸血症患者在区域及网络水平上存在脑功能异常。

Abstract:

ObjectiveTo assess the brain functions and explore the neurobiological mechanism of emotional and cognitive changes in male patients with hyperuricemia. MethodsForty-one untreated male patients with hyperuricemia and 41 healthy control subjects were recraited through communities during, and all of them underwent examinations of fasting serum uric acid (SUA), neuropsychological test and resting-state functional magnetic resonance imaging (rs-fMRI). The amplitude of low-frequency fluctuation (ALFF) was analyzed to determine the seed points, and the functional connections between the abnormal seed points and the voxels of the whole brain were analyzed. ResultsThe patients with hyperuricemia showed significantly decreased ALFF in the left inferior temporal gyrus (ITG.L) and increased ALFF in the bilateral inferior frontal gyrus (IFG.B) compared with the control subjects. The FC intensity of the bilateral cuneus (CUN.B) was enhanced when the extreme point of ITG.L was chosen as the seed point; the intensity of functional connection between the left thalamus (THA.L) and the right caudate nucleus (CAU.R) was enhanced when the extreme point of the IFG.L was the seed point. The results of SUA analysis and neuropsychological and behavioral tests showed that SUA levels were inversely correlated with the working memory reaction time (r=0.320, P=0.041), and the ALFF in the ITG.L was positively correlated with the working memory accuracy (r=0.535, P<0.001). The ALFF in IFG.L and IFG.R was positively correlated with the accuracy of the executive function (r=0.461, P=0.002; r=0.566, P<0.001, respectively); the strength of functional connection of the IFG.L with the THA.L and with the CAU.R was inversely correlated with sleep quality (r=-0.361, P=0.020) and depressive state (r=-0.343, P=0.028) of the patients, respectively. ConclusionBrain abnormalities at regional and network levels are present in male patients with hyperuricemia, and these findings provide new insights into the mechanisms underlying the cognitive and emotional changes in patients with hyperuricemia.
 

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更新日期/Last Update: 2020-07-23