[1]李妹玲,刘丹,杨全,等.新型冠状病毒病患者淋巴细胞亚群与CT肺炎症指数相关性分析[J].第三军医大学学报,2020,42(09):872-878.
 LI Meiling,LIU Dan,YANG Quan,et al.Correlation between lymphocyte subsets and CT pneumonia index in patients with coronavirus disease 2019[J].J Third Mil Med Univ,2020,42(09):872-878.
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新型冠状病毒病患者淋巴细胞亚群与CT肺炎症指数相关性分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第09期
页码:
872-878
栏目:
特别报道
出版日期:
2020-05-15

文章信息/Info

Title:
Correlation between lymphocyte subsets and CT pneumonia index in patients with coronavirus disease 2019
作者:
李妹玲刘丹杨全应洁周微
重庆医科大学附属永川医院放射科
Author(s):
LI Meiling LIU Dan YANG Quan YING Jie ZHOU Wei

Department of Radiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China

关键词:
冠状病毒病-19肺炎CT淋巴细胞
Keywords:
COVID-19 pneumonia CT image lymphocytes
分类号:
R392.3; R563.1; R814.42
文献标志码:
A
摘要:

目的探讨2019冠状病毒病(COVID-19)患者的淋巴细胞亚群与CT肺炎症指数的相关性。方法收集本院2020年1-2月收治的80例经临床及核酸检测确诊的COVID-19患者资料,其中男性45例,女性35例,年龄18~89岁,平均51.2岁。按严重程度分为2组:非重症(普通型)组68例、重症(重型、危重型)组12例,分析患者的临床资料、胸部CT图像并计算肺炎症指数。观察两组不同发病阶段淋巴细胞亚群、CT肺炎症指数情况,肺炎症指数与淋巴细胞亚群之间的相关性采用Spearman分析。结果COVID-19患者T淋巴细胞亚群计数正常或减低,C反应蛋白、IL-6升高或正常。与非重症组比较,重症组在发病1周内、1~2周、2周以上3个时间段CD3+、CD4+值显著下降(P<0.05),CT肺炎症指数明显上升(P<0.05),在前2个时间段CD8+值明显下降(P<0.05)。CT肺部炎症高峰时间主要出现在发病2周以内,肺炎开始吸收时间主要出现在发病1~3周。CT肺炎症指数与CD3+、CD4+、CD8+、Lym值均呈显著负相关(P<0.05)。结论COVID-19患者T淋巴细胞亚群值越低,CT肺部炎症越重,病情越严重。

Abstract:

ObjectiveTo explore the correlation between lymphocyte subtypes and CT pulmonary inflammatory index in patients with coronavirus disease 2019 (COVID-19). MethodsClinical data of 80 COVID-19 patients identified by nucleic acid test and clinical symptoms admitted in our hospital from January to February 2020 were collected in this study. They were 45 males and 35 females, and at an average age of 51.2 years. According to the severity of the disease, they were divided into the non-severe group (ordinary type, n=68) and the severe group (serious and critical type, n=12). The clinical data, chest CT findings and pneumonia index of the patients were observed and analyzed. Spearman analysis was employed to analyze the correlation between pneumonia index and lymphocyte subtypes count. ResultsThe results showed that the T lymphocyte subsets of patients with COVID-19 were normal or decreased, and the levels of C-reactive protein and IL-6 were increased or normal. During the following courses of disease, within 1 week, weeks 1~2 and 2 weeks later, counts of CD3+ and CD4+ T cells in the severe group were decreased significantly at above 3 periods (P<0.05), CT pulmonary inflammatory index was obviously elevated at the 3 periods (P<0.05), and CD8+ T cells count was decreased during the former 2 periods (P<0.05), when compared with the non-severe group. It was found that the peak time of CT pulmonary inflammation was mainly within 2 weeks after onset, and the beginning time of pneumonia absorption was mainly within 1~3 weeks. The pneumonia index was negatively correlated with CD3+, CD4+, CD8+ T cells and Lym counts (P<0.05). ConclusionThe lower counts of lymphocyte subsets are, the severer the CT pulmonary inflammation is, and the more serious the condition is in COVID-19 patients.

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更新日期/Last Update: 2020-05-06