[1]黄澄澄,庞科,高红丽.重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析[J].第三军医大学学报,2020,42(09):883-886.
 HUANG Chengcheng,PANG Ke,GAO Hongli.Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases[J].J Third Mil Med Univ,2020,42(09):883-886.
点击复制

重庆市某医院89例新型冠状病毒肺炎患者的临床特征分析(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第09期
页码:
883-886
栏目:
特别报道
出版日期:
2020-05-15

文章信息/Info

Title:
Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases
作者:
黄澄澄庞科高红丽
重庆医科大学附属永川医院:老年病科,老年病科及新冠病房,超声科
 
Author(s):
HUANG Chengcheng PANG Ke GAO Hongli

Department of Geriatrics, Ward of Geriatrics and Novel Coronavirus Pneumonia, Department of Ultrasonography, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China

关键词:
新型冠状病毒肺炎临床特征T淋巴细胞C反应蛋白白介素6
Keywords:
coronavirus disease 2019 clinical characteristics T lymphocyte C-reactive protein interleukin 6
分类号:
R181.32; R373.1; R563.19
文献标志码:
A
摘要:

目的分析重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的临床特征。方法回顾性分析2020年1月22日至2020年2月17日重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的流行病学资料、临床症状及实验室检查结果。结果发热和咳嗽为COVID-19的主要症状,但仍有6例无症状携带者;重型组的淋巴细胞绝对值、淋巴细胞百分比、CD3+细胞计数、CD4+细胞计数、CD8+细胞计数明显低于普通组,差异具有统计学意义(P<0.05)。重型组的C反应蛋白及IL-6水平明显高于普通组及轻症组,差异具有统计学意义(P<0.05)。病情严重程度与年龄、患2型糖尿病、C反应蛋白水平、IL-6水平呈正相关,而与淋巴细胞、CD3+细胞、CD4+细胞及CD8+细胞计数呈负相关。多因素Logistic回归分析提示,C反应蛋白升高及CD8+细胞计数降低是重症COVID-19的独立影响因素。结论新型冠状病毒肺炎发热咳嗽为主要症状,C反应蛋白及CD8细胞计数对病情评估有帮助,免疫功能与病情严重程度密切相关。

Abstract:

ObjectiveTo analyze the clinical characteristics of 89 cases of coronavirus disease 2019 (COVID-19) in Yongchuan Hospital of Chongqing Medical University. MethodsThe epidemiological data, clinical symptoms and results of laboratory tests of 89 COVID-19 patients admitted in our hospital from January 22 to February 17 2020 were collected and retrospectively analyzed. ResultsFever and cough were the main symptoms of COVID-19, but there were 6 asymptomatic carriers in the cohort. The severe group had significantly lower lymphocyte absolute value, lymphocyte percentage, and the counts of CD3+, CD4+ and CD8+ cells when compared with the ordinary group (P<0.05). The severe group also had obviously high levels of C-reactive protein and IL-6 than the ordinary and mild groups (P<0.05). The severity of the disease was positively correlated with age, type 2 diabetes, C-reactive protein and IL-6 levels, and negatively correlated with the counts of lymphocytes, CD3+, CD4+ and CD8+ cells. Multivariate Logistic regression analysis indicated that increased C-reactive protein and decreased CD8+ cell count were independent factors for the severity of the condition. ConclusionFever and cough are the main symptoms of COVID-19. C-reactive protein and CD8+ cell count are helpful for the assessment of the disease, and immune function is closely related to the severity of the disease.

参考文献/References:

[1]中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组. 新型冠状病毒肺炎流行病学特征分析 [J]. 中华流行病学杂志, 2020, 41(2): 145-151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003.
Novel Coronavirus Pneumonia Emergency Response Epidemiology Team of Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China[J]. Chin J Epidemiol, 2020, 41(2): 145-151. DOI: 10.3760/cma.j.issn.0254-6450.2020.02.003.
[2]国家卫生健康委. 新型冠状病毒感染的肺炎诊疗方案(试行第五版)[J]. 中国中西医结合杂志,2020: 1-3. DOI:10.7661/j.cjim.20200202.064.
National Health Commission. Diagnosis and treatment of pneumonia caused by new coronavirus infection (trial version 5) [J]. Chin J Integr Trad West Med, 2020: 1-3. DOI:10.7661/j.cjim.20200202.064.
[3]WU F, ZHAO S, YU B, et al. A new coronavirus associated with human respiratory disease in China[J]. Nature, 2020,579(7798): 1-8. DOI:10.1038/s41586-020-2008-3.
[4]中华医学会儿科学分会, 中华儿科杂志编辑委员会. 儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版) [J]. 中华儿科杂志,2020,58(3): 169-174.DOI: 10.3760/cma.j.issn.0578-1310.2020.03.001.
Branch of Pediatrics of Chinese Medical Association. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition) [J]. Chin J Pediatr, 2020,58(3): 169-174.DOI: 10.3760/cma.j.issn.0578-1310.2020.03.001.
[5]杜永浩,金晨望,杨健,等. 家庭聚集性早期新型冠状病毒肺炎的临床与CT表现初步探讨[J]. 西安交通大学学报(医学版), 2020, 41(2): 215.
DU Y H, JIN C W, YANG J, et al. Preliminary study of clinical and CT manifestations of family-associated early new-type coronavirus pneumonia [J]. J Xi’an Jiaotong Univ (Med Edition), 2020, 41(2): 215.
[6]PREGLEJ T, HAMMINGER P, LUU M, et al. Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation[J]. JCI Insight, 2020, 5(4): 133393. DOI:10.1172/jci.insight.133393.
[7]STENGER S, HANSON D A, TEITELBAUM R, et al. An antimicrobial activity of cytolytic T cells mediated by granulysin[J]. Science, 1998, 282(5386): 121-125. DOI:10.1126/science.282.5386.121.
[8]陈威巍, 谢杨新, 张云辉, 等. 甲型H1N1流感患者外周血白细胞和淋巴细胞亚群变化分析[J]. 中华实验和临床病毒学杂志, 2010, 24(5): 331-333. DOI:10.3760/cma.j.issn.1003-9279.2010.05.004.
CHEN W W, XIE Y X, ZHANG Y H, et al. Changes and analysis of peripheral white blood cells and lymphocyte subsets for patients with pandemic influenza A virus (H1N1) infection[J]. Chin J Exp Clin Virol, 2010, 24(5): 331-333. DOI:10.3760/cma.j.issn.1003-9279.2010.05.004.
[9]ZHAO Y, ZHANG Y H, DENNEY L, et al. High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection[J]. Am J Respir Crit Care Med, 2012, 186(12): 1292-1297. DOI:10.1164/rccm.201207-1245OC.
[10]HIGDON M M, LE T, O’BRIEN K L, et al. Association of C-reactive protein with bacterial and respiratory syncytial virus-associated pneumonia among children aged 5 years in the PERCH study[J]. Clin Infect Dis, 2017, 64(suppl_3): S378-S386. DOI:10.1093/cid/cix150.

相似文献/References:

[1]刘静,张伟京,苏航.间变性大细胞淋巴瘤19例临床特征分析[J].第三军医大学学报,2008,30(11):997.
[2]谢丹凤,李秋.509例儿童肾活检病理及临床分析[J].第三军医大学学报,2011,33(16):1736.
 Xie Danfeng,Li Qiu.Pathological characteristics and clinical manifestations in 509 children with renal diseases from a single unit[J].J Third Mil Med Univ,2011,33(09):1736.
[3]万敏,唐小婷,张巧,等.哮喘-慢阻肺重叠综合征患者240例临床特征分析[J].第三军医大学学报,2015,37(21):2181.
 Wan Min,Tang Xiaoting,Zhang Qiao,et al.Clinical characteristics of asthma and COPD overlap syndrome: report of 240 cases[J].J Third Mil Med Univ,2015,37(09):2181.
[4]刘征,蒋利萍,刘玮,等.4例Chediak-Higashi综合征的临床特征和LYST基因分析[J].第三军医大学学报,2011,33(17):1838.
 Liu Zheng,Jiang Liping,Liu Wei,et al.Clinical features of Chediak-Higashi syndrome and LYST gene in 4 patients[J].J Third Mil Med Univ,2011,33(09):1838.
[5]王莉,李秋,张伟,等.964例儿童原发性肾病综合征的临床分析[J].第三军医大学学报,2008,30(19):1849.
 WANG Li,LI Qiu,ZHANG Wei,et al.Primary nephrotic syndrome in children: a clinical analysis of 964 cases[J].J Third Mil Med Univ,2008,30(09):1849.
[6]刘明,邓国宏,谭顺,等.慢加急性肝衰竭前期临床常规预警指标研究[J].第三军医大学学报,2012,34(08):772.
 Liu Ming,Deng Guohong,Tan Shun,et al.Routine early clinical warning indicators of acute-on-chronic pre-liver failure[J].J Third Mil Med Univ,2012,34(09):772.
[7]李志伟,陈华萍,马千里,等.不同气道炎症表型哮喘278例的临床特征分析[J].第三军医大学学报,2013,35(08):801.
 Li Zhiwei,Chen Huaping,Ma Qianli,et al.Clinical characteristics of different airway inflammatory phenotypes in patients with asthma[J].J Third Mil Med Univ,2013,35(09):801.
[8]何继菲,熊鸿燕,李力.某医院599例早产病例临床特征分析[J].第三军医大学学报,2014,36(09):966.
 He Jifei,Xiong Hongyan,Li Li.Clinical features of premature birth: a report of 599 cases from a hospital[J].J Third Mil Med Univ,2014,36(09):966.
[9]陈盛,毛青,向德栋,等.儿童埃博拉病毒病的诊治策略[J].第三军医大学学报,2015,37(04):291.
 Chen Sheng,Mao Qing,Xiang Dedong,et al.Diagnosis and treatment strategies for Ebola virus disease in children[J].J Third Mil Med Univ,2015,37(09):291.
[10]陈辉亚,张献全.不同分子分型乳腺癌的临床特征及预后分析[J].第三军医大学学报,2015,37(14):1424.
 Chen Huiya,Zhang Xianquan.Clinical characteristics and prognosis analysis of different subtypes of breast cancer[J].J Third Mil Med Univ,2015,37(09):1424.

更新日期/Last Update: 2020-05-06