[1]高乐女,吴红,游苘霞,等.7 829例疑似强直性脊柱炎患者HLA-B27抗原阳性率及分型研究[J].第三军医大学学报,2020,42(12):1220-1224.
 GAO Lenyu,WU Hong,YOU Qingxia,et al.Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis[J].J Third Mil Med Univ,2020,42(12):1220-1224.
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7 829例疑似强直性脊柱炎患者HLA-B27抗原阳性率及分型研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第12期
页码:
1220-1224
栏目:
临床医学
出版日期:
2020-06-30

文章信息/Info

Title:
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis
作者:
高乐女吴红游苘霞王勇
陆军军医大学(第三军医大学)第一附属医院风湿免疫科
 
Author(s):
GAO Lenyu WU Hong YOU Qingxia WANG Yong

Department of Rheumatology and Immunology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China

关键词:
HLA-B27亚型强直性脊柱炎
Keywords:
HLA-B27 subtype ankylosing spondylitis
分类号:
R195.4;R392.11;R593.23
文献标志码:
A
摘要:

目的通过对重庆地区疑似强直性脊柱炎(ankylosing spondylitis, AS)的患者及部分亲属的人类白细胞表面抗原-B27(HLA-B27)阳性情况进行分析,了解该抗原不同表型在本地区疑似患者中分布的差异。方法回顾性分析本院2018年1月1日至2019年11月29日诊治的重庆地区7 829例疑似AS的患者及部分亲属的临床资料,采用序列特异性引物聚合酶链反应(PCR-SSP)法检测血液标本所得的HLA-B27基因亚型的分型情况。结果7 829例数据中HLA-B27抗原阳性有2 112例,阳性率为26.98%;其中男性阳性率显著高于女性(33.87% vs 18.58%,P<0.01)。其中B*2704型有1 655例(78.36%),B*2705/07型有358例(16.95%)。有46例HLA-B27阳性者合并眼部疾病,其中B*2704型有36例(78.26%),并且以葡萄膜炎多见(34/46)。结论重庆地区人群AS疑似病例HLA-B27抗原阳性率男性明显高于女性。HLA-B27亚型以B*2704、B*2705/07为主,且前者是重庆地区AS的发病易感基因亚型。AS合并眼部疾病者以葡萄膜炎多见,HLA-B27基因亚型以B*2704型为主。
 

Abstract:

ObjectiveTo analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients. MethodsWe retrospectively analyzed the clinical data of 7 829 patients with suspected AS and some of their relatives, who were diagnosed in Chongqing between January 1, 2018 and November 29, 2019. HLA-B27 genotypes were determined using a sequence-specific primer polymerase chain reaction (PCR-SSP) . ResultsOf the 7 829 patients, 2 112 were positive for HLA-B27 antigen, with a positive rate of 26.98%. The positive rate of HLA-B27 antigen was significantly higher in the male than in the female patients (33.87% vs 18.58%, P<0.01). A total of 1 655 (78.36%) patients had a B*2704 genotype and 358 (16.95%) had a B*2705/07 genotype of HLA-B27 antigen. Forty-six of the HLA-B27-positive patients were found to have ocular diseases, among whom 36 (78.26%) patients had a B*2704 genotype; uveitis was the most frequent ocular disease in these patients (34/46). ConclusionThe patients with suspected AS in Chongqing have a significantly higher rate HLA-B27 antigen positivity than the normal population, and the positive rate is significantly higher in male than in female patients. The HLA-B27 genotypes are predominantly B*2704 and B*2705/07, and the former is associated with AS susceptibility. Uveitis is common in HLA-B27-positive AS patients with ocular diseases, who have a predominant B*2704 genotype.

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更新日期/Last Update: 2020-06-19