[1]彭李,徐松,胡晓飞,等.癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究[J].陆军军医大学学报(原第三军医大学学报),2020,42(11):1150-1158.
 PENG Li,XU Song,HU Xiaofei,et al.Resting brain functional imaging of breast cancer survivors with fear of cancer recurrence based on ReHo method[J].J Amry Med Univ (J Third Mil Med Univ),2020,42(11):1150-1158.
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癌症复发恐惧的乳腺癌幸存者静息态脑功能成像研究(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第11期
页码:
1150-1158
栏目:
医学心理学
出版日期:
2020-06-15

文章信息/Info

Title:
Resting brain functional imaging of breast cancer survivors with fear of cancer recurrence  based on ReHo method
作者:
彭李徐松胡晓飞薛源李敏
陆军军医大学(第三军医大学):医学心理系军事心理学教研室,第一附属医院放射科;解放军第991医院精神科
 
Author(s):
PENG Li XU Song HU Xiaofei XUE Yuan LI Min

Department of Military Psychology, Faculty of Medical Psychology, 3Department of Radiology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038; 2Department of Psychiatry, No. 991 Hospital of PLA, Xiangyang, Hubei Province, 441003, China

关键词:
癌症复发恐惧乳腺癌幸存者静息态ReHo功能磁共振成像
Keywords:
fear of cancer recurrence breast cancer survivors resting state regional homogeneity functional magnetic resonance imaging
分类号:
R737.9; R741.04; R749.72
文献标志码:
A
摘要:

目的探讨具有癌症复发恐惧的乳腺癌幸存者静息状态脑功能的特点。方法2017年5-7月按照自愿报名的形式招募陆军军医大学第一附属医院乳腺甲状腺外科就诊的癌症复发恐惧乳腺癌幸存者59例。采集28例低癌症复发恐惧乳腺癌幸存者及31例高癌症复发恐惧乳腺癌幸存者进行静息态磁共振脑功能成像数据,采用局部一致性(regional homogeneity, ReHo)方法,比较两组平均脑ReHo图的差异,考察高、低癌症复发恐惧的两组乳腺癌幸存者在大脑局部自发神经元活动一致性上的差异。结果与低癌症复发恐惧组的乳腺癌幸存者相比,高癌症复发恐惧组的乳腺癌幸存者在静息状态下脑的ReHo值增高部位为左侧尾状核,ReHo值降低部位为右侧楔前叶(P<0.01)。左侧尾状核与癌症复发恐惧呈显著负相关(r=-0.501,P<0.05);右侧楔前叶与癌症复发恐惧呈显著正相关(r=0.505,P<0.05)。结论癌症复发恐惧对静息态下左侧尾状核和右侧楔前叶的自发神经元活动的一致性有明显影响,这可能与乳腺癌幸存者的情绪和认知功能变化有关。

Abstract:

ObjectiveTo investigate the characteristics of resting brain function in breast cancer survivors with fear of cancer recurrence. MethodsA total of 59 breast cancer survivors were recruited by voluntary enrollment from Department of Breast and Thyroid Surgery, First Affiliated Hospital, Army Medical University during May and July 2017, and were divided into the low fear of cancer recurrence group (n=28) and high fear group (n=31) according to the results of Fear of Cancer Recurrence Inventory (FCRI). Their resting brain functional images were collected, and the differences of mean brain regional homogeneity (ReHo) map were compared between the 2 groups so as to investigate the consistency of spontaneous neuron activities in the brain. ResultsCompared to the low fear group, the ReHo value was increased in the left caudate nucleus and was decreased in the right anterior cuneiform lobe in the high fear group (P<0.01). The value in the left caudate nucleus was negatively correlated with the total score of FCR (r=-0.501, P<0.05), and that in the right anterior cuneiform lobe was positively with the total score (r=0.505, P<0.05). ConclusionFear of cancer recurrence has significant effects on the consistency of spontaneous neuron activity in the left caudate nucleus and the right anterior cuneiform lobe in resting state, which may be related to the change of emotion and cognitive function of breast cancer survivors.

更新日期/Last Update: 2020-05-30