[1]宋娜丽,阮潜瑛,刘奇,等.55~60周岁献血者捐献单采血小板的安全性及有效性探讨[J].第三军医大学学报,2020,42(03):278-281.
 SONG Nali,RUAN Qianying,LIU Qi,et al.Safety and efficacy of apheresis platelet donation by 55- to 60-year-old individuals [J].J Third Mil Med Univ,2020,42(03):278-281.
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55~60周岁献血者捐献单采血小板的安全性及有效性探讨(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
42卷
期数:
2020年第03期
页码:
278-281
栏目:
临床医学
出版日期:
2020-02-15

文章信息/Info

Title:
Safety and efficacy of apheresis platelet donation by 55- to 60-year-old individuals 
作者:
宋娜丽阮潜瑛刘奇李晨晨陈寒梅陈敏刁荣华王珊王世春
陆军军医大学(第三军医大学)第一附属医院输血科,中国人民解放军重庆血站
Author(s):
SONG Nali RUAN Qianying LIU Qi LI Chenchen CHEN Hanmei CHEN Min DIAO Ronghua WANG Shan WANG Shichun

Department of Blood Transfusion, First Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400038, China

关键词:
55~60周岁献血者单采血小板血小板计数增加指数献血反应
Keywords:
donors aged 55-60 years apheresis platelets corrected count increment donor reaction
分类号:
R195; R331.143; R457.12
文献标志码:
A
摘要:

目的 探讨55~60周岁献血者捐献单采血小板的安全性及有效性。方法选取中国人民解放军重庆血站2013年1月1日至2019年5月31日期间的固定单采血小板献血者45名,将其分为3组,A组为18~30周岁的献血者,B组为31~54周岁的献血者,C组为55~60周岁的献血者,每组各15名。对比分析3组献血者的捐献前血常规、献血中献血反应观察、单采血小板产品质量、输注患者体内血小板计数增加指数(corrected count increment,CCI)及止血效果观察。结果3组献血者在献血过程中无献血不良反应,3组献血者血常规比较,平均血小板体积(mean platelet volume,MPV)随年龄组增大而增大,且A组与C组差异有统计学意义(7.77±0.61 fl vs 8.71±1.21 fl,P<0.05),其他指标差异无统计学意义。3组单采血小板产品质量均符合国家现行《全血与成分血质量要求》,且组间无统计学差异。3组单采血小板制剂输注患者体内后疗效比较,每组输注后血小板计数增加值明显,差异有统计学意义(P<0.01)。组间比较,C组与A组的血小板增加值和CCI24 h差异有统计学意义(P<0.05)。结论 55~60周岁的献血者定期献血是安全的,其血液质量符合我国现行《全血与成分血质量要求》,输注患者体内可有效改善患者止凝血状态。

Abstract:

Objective To investigate the safety and efficacy of apheresis platelet (PLT) donation by individuals aged between 55 and 60 years. MethodsA total of 45 apheresis PLT donors were recruited from Chongqing Blood Station from January 1, 2013 to May 31, 2019. They were divided into group A (aged from 18 to 30 years), group B (31 to 54 years), and group C (55 to 60 years), with 15 donors in each group. Routine blood indexes before donation, donor reaction, quality of apheresis PLT, corrected count increment (CCI), and hemostatic effect after transfusion were observed and analyzed. ResultsNo donor reactions occurred in all the donors. Routine blood test before donation showed that the mean platelet volume (MPV)  was increased as the age got older, and there was statistical difference between group A and group C (7.77±0.61 vs 8.71±1.21 fl, P<0.05), but no significant differences were seen in other indicators. All the apheresis PLT from 3 aged groups met the current quality requirements of whole blood and blood components in China, and no difference was observed in the requirements. After PLT transfusion, all the recipients obtained significant the increment of PLT count (P<0.01). The CCI showed significant difference between group C and group A (P<0.05). ConclusionIt is safe to donate apheresis PLTs for donors aged 55-60 regularly, and the apheresis PLT meet the current quality requirements of whole blood and blood components in our country. The apheresis PLTs could help the recipients improve their hemostatic effect after transfusion.

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更新日期/Last Update: 2020-02-06