[1]袁亮,周德凯,郭振华,等.0.1%平阳霉素在儿童口腔血管畸形治疗中的应用[J].第三军医大学学报,2019,41(20):2017-2022.
 YUAN Liang,ZHOU Dekai,GUO Zhenhua,et al.Percutaneous local injection of 0.1% pingyangmycin for treatment of oral vascular malformation in children[J].J Third Mil Med Univ,2019,41(20):2017-2022.
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0.1%平阳霉素在儿童口腔血管畸形治疗中的应用(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
41卷
期数:
2019年第20期
页码:
2017-2022
栏目:
临床医学
出版日期:
2019-10-30

文章信息/Info

Title:
Percutaneous local injection of 0.1% pingyangmycin for treatment of oral vascular malformation in children
作者:
袁亮周德凯郭振华何昀向丽
重庆医科大学附属儿童医院血管瘤专科, 门诊外科
Author(s):
YUAN Liang ZHOU Dekai GUO Zhenhua HE Yunx XIANG Li

Department of Hemangioma, Department of Outpatient Surgery, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China

关键词:
平阳霉素治疗口腔血管畸形
Keywords:
pingyangmycin percutaneous injection oral vascular malformation
分类号:
R654.4;R726.2;R782.2
文献标志码:
A
摘要:

目的 探讨0.1%平阳霉素注射治疗儿童口腔血管畸形的临床疗效及安全性,为临床应用提供经验。方法 回顾2009年1月至2015年12月,在重庆医科大学附属儿童医院血管瘤专科有完整记录及随访资料的56例口腔血管畸形患儿,所有病例末次治疗结束后均随访2年。分析患儿血管畸形大小分型、部位等临床资料。统计患儿治疗效果和不良反应。分析典型病例,总结临床治疗要点。结果56 例患儿均完成全程治疗,其中有效48例,基本治愈45例,无效7例。4例患儿出现局部溃疡、色素沉着等,无药物相关严重不良反应发生。本组患儿基本治愈率高于文献报道的平均水平。结论 0.1%平阳霉素经皮局部灌注治疗儿童口腔血管畸形,是一种安全有效且较易于掌握的治疗方法。

Abstract:

Objective To investigate the clinical efficacy and safety of percutaneous local injection of 0.1% pingyangmycin for treatment of oral vascular malformation in children. MethodsThis retrospective study was conducted among 56 children with oral vascular malformation with complete clinical and follow-up data, who received treatment by percutaneous injection of 0.1% pingyangmycin between January, 2009 and December, 2015. In all the cases the dose of pingyangmycin was determined based on the size, depth and location of the tumors. The patients received the injections at the interval of 2-4 weeks, and in each case the number of the injections ranged from 1 to 16. The patients were followed up for 2 years after the last treatment to evaluate the therapeutic effects and adverse events related to the treatment. ResultsAll the 56 children completed the whole treatment course. Forty-eight of the patients showed favorable response to the treatment, and 45 were basically cured; 7 patients failed to respond to the treatment. During the treatment, 4 patients experienced local ulcer and pigmentation; none of the patients showed severe adverse events related to the injections. The basic cure rate in these children was higher than the average rate reported in previous studies. ConclusionPercutaneous local injection of 0.1% pingyangmycin is a safe, effective and convenient treatment for oral vascular malformation in children.

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更新日期/Last Update: 2019-10-25