[1]郑玮玮,陈金通,刘益娟,等.TNF-β基因+252位点多态性及幽门螺杆菌感染与非贲门型胃癌易感性的研究[J].第三军医大学学报,2019,41(16):1566-1571.
　ZHENG Weiwei,CHEN Jintong,LIU Yijuan,et al.Association of tumor necrosis factor-β+252 gene polymorphism and H.pylori infection with the susceptibility to non-cardiac gastric cancer[J].J Third Mil Med Univ,2019,41(16):1566-1571.
点击复制

TNF-β基因+252位点多态性及幽门螺杆菌感染与非贲门型胃癌易感性的研究(/HTML )
分享到：

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
41卷
期数:
2019年第16期
页码:
1566-1571
栏目:
基础医学
出版日期:
2019-08-30

文章信息/Info

Title:
Association of tumor necrosis factor-β+252 gene polymorphism and H.pylori infection with the susceptibility to non-cardiac gastric cancer
作者:
郑玮玮; 陈金通; 刘益娟; 俞星; 王承党
福建医科大学附属第一医院消化内科，福建医科大学第一临床医学院，福建医科大学消化系病研究室 
 
Author(s):
ZHENG Weiwei;  CHEN Jintong;  LIU Yijuan;  YU Xing;  WANG Chengdang

Department of Gastroenterology, the First Affiliated Hospital of Fujian Medical University, the First Clinical Medical College of Fujian Medical University, Department of Digestive Diseases of Fujian Medical University, Fuzhou, Fujian Province, 350005, Chin

关键词:
非贲门型胃癌; TNF-β +252; 基因多态性; Hp感染
Keywords:
non-cardiac gastric cancer;  tumor necrosis factor-β  gene polymorphisms;  Helicobacter pylori infection
分类号:
R181.32；R394.2；R735.2
文献标志码:
A
摘要:

目的 探讨肿瘤坏死因子β（TNF-β）基因+252位点多态性和幽门螺旋杆菌（Helicobacter pylori, Hp）感染对非贲门型胃癌易感性的影响。方法 选取2015年3月至2018年12月在福建医科大学附属第一医院住院的非贲门型胃癌患者215例为病例组，以同期215例健康体检者为对照组。按Lauren标准将胃癌患者进行病理分型，分析各TNF-β基因+252位点多态性基因型分布与Hp感染、非贲门胃癌临床病理学特征之间的关系。结果与Hp感染阴性者相比，Hp感染阳性者患胃癌的危险度更高(OR=1.881, 95%CI 1.277~2.770)。与G/G基因型相比，G/A和A/A型患者患胃癌危险度更高[OR值分别为1.950（1.151~3.303）、2.226（1.260~3.932）]。在对照组中，Hp感染阴性和阳性患者基因型差异无统计学意义（χ2=2.801, P=0.246）。在病例组中，Hp感染阳性患者G/A、A/A比例高于Hp感染阴性患者（χ2=6.265, P=0.044）。肠型胃癌患者中G/A+A/A基因型频率相比对照组增加（χ2=11.325, P=0.003）。携带TNF-β基因+252位点A等位基因与Hp感染存在交互作用。结论TNF-β基因+252位点G/A基因型和A/A基因型与非贲门型胃癌的易感性有关, TNF-β基因与Hp感染存在交互作用。

Abstract:

Objective To evaluate the association of tumor necrosis factor-β (TNF-β) +252 gene polymorphisms and H.pylori (Hp) infection with the susceptibility to non-cardiac gastric cancer. MethodsA total of 215 patients with non-cardiac cancer and 215 healthy control subjects were recruited from the First Affiliated Hospital of Fujian Medical University between March, 2015 and December, 2018. Pathological typing of gastric cancer was performed according to Lauren’s criteria, and the correlation of TNF-β+252 genotypes and Hp infection with the clinicopathological characteristics of the patients was analyzed. ResultsCompared with Hp-negative patients, Hp-positive patients had a significantly increased risk for gastric cancer (OR=1.881, 95%CI: 1.277-2.770). Compared with G/G genotype of TNF-β +252, the genotypes G/A and A/A were associated with significantly increased risks for gastric cancer [OR=1.950 (1.153-3.303) and 2.226 (1.260-3.932), respectively]. In the control group, no significant difference was found in the genotype distribution between the Hp-negative and Hp-positive subjects (Chi-square=2.801, P=0.246). In the case group, the proportion of G/A and A/A genotypes was significantly greater in Hp-positive patients than in Hp-negative patients (Chi-square=6.265, P=0.044). The G/A+A/A genotype frequencies were significantly higher in patients with intestinal gastric cancer than in the control group (Chi-square=11.325, P=0.003). There was an interaction between the allele A in TNF-β gene +252 and Hp infection. ConclusionHp infection increases the susceptibility to non-cardiac gastric cancer, which is also associated with TNF-β gene +252 G/A and A/A genotypes

参考文献/References:

[1]CHEN W Q, ZHENG R S, BAADE P D, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2): 115-132. DOI: 10.3322/caac.21338.
[2]FORD A C, FORMAN D, HUNT R H, et al. Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials[J]. BMJ, 2014, 348: g3174. DOI: 10.1136/bmj.g3174.
[3]PENG Q L, CHEN Z P, LU Y, et al. Current evidences on XPC polymorphisms and gastric cancer susceptibility: A meta-analysis[J].Diagn Pathol, 2014, 9: 96. DOI: 10.1186/1746-1596-9-96.
[4]WU D D, ZHANG J X, LI J, et al. Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcer: A systemic review and meta-analysis[J]. Asian Pac J Cancer Prev, 2014, 15(7): 3021-3027.
[5]PAN X F, WEN Y, LOH M, et al. Interleukin-4 and -8 gene polymorphisms and risk of gastric cancer in a population in Southwestern China[J]. Asian Pac J Cancer Prev, 2014, 15(7): 2951-2957.
[6]JIANG Y H, WANG X D, CHENG Y, et al. Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: A meta-analysis and literature review[J].Oncotarget, 2017, 8(57): 97571-97583. DOI: 10.18632/oncotarget.18813.
[7]KINDLUND B, SJLING , YAKKALA C, et al. CD4+ regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-Β[J]. Gastric Cancer, 2017, 20(1): 116-125.DOI: 10.1007/s10120-015-0591-z.
[8]LIPPITZ B E. Cytokine patterns in patients with cancer: A systematic review[J]. Lancet Oncol, 2013, 14(6): e218-e228. DOI: 10.1016/S1470-2045(12)70582-X.
[9]YANG L, FENG R N, LIU G Y, et al. TNF-β +252A>G polymorphism and susceptibility to cancer[J]. J Cancer Res Clin Oncol, 2013, 139(5): 765-772. DOI: 10.1007/s00432-013-1384-6.
[10]FIGURA N, MARANO L, MORETTI E, et al. Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike[J]. World J Gastrointest Oncol, 2016, 8(1): 40-54. DOI: 10.4251/wjgo.v8.i1.40.
[11]YOON J H, SONG J H, KANG Y H, et al. TNF-α and TNF-β polymorphisms with susceptibility to gastric cancer in a Korean population[J]. Mol Cell Toxicol, 2010, 6(2): 161-167. DOI: 10.1007/s13273-010-0023-4.
[12]DE OLIVEIRA J G, ROSSI A F, NIZATO D M, et al. Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer[J]. Tumour Biol, 2015, 36(12): 9159-9170. DOI: 10.1007/s13277-015-3593-x.
[13]STUBLJAR D, JEVERICA S, JUKIC T, et al. The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection[J].Radiol Oncol, 2015, 49(3): 256-264. DOI: 10.2478/raon-2014-0041.
[14]KEIKANLOO N R, MEHRZAD J, MOHAMADDOUST H, et al. Studying the polymorphism of TNF-alfa And TNF-beta genes among people suffering from Helicobacter pylori infection[J]. J Clin Anal Med, 2017, 8(Suplement 4): 399-402. DOI: 10.4328/jcam.5189.
[15]SUZUKI G, CULLINGS H, FUJIWARA S, et al. LTA 252GG and GA genotypes are associated with diffuse-typenoncardia gastric cancer risk in the Japanese population[J]. Helicobacter, 2009, 14(6): 571-579. DOI: 10.1111/j.1523-5378.2009.00694.x.
[16]何选秋, 李粉霞, 杨学习, 等. LTA基因单核苷酸多态位点与胃癌易感性的研究[J]. 分子诊断与治疗杂志, 2011, 3(4): 241-244. DOI: 10.3969/j.issn.1674-6929.2011.04.006.
HE X Q, LI F X, YANG X X, et al. Investigation of single nucleotide polymorphism of LTA rs909253 with gastric cancer[J]. J Mol Diagn Ther, 2011, 3(4): 241-244. DOI: 10.3969/j.issn.1674-6929.2011.04.006.
[17]REIS C A, MAGALHES A. Glycosyltransferases and Gastric Cancer[M]//REIS C A, MAGALHES A. eds. Glycosignals in cancer: mechanisms of malignant phenotypes. Tokyo: Springer Japan, 2016: 17-32. DOI: 10.1007/978-4-431-55939-9_2.
 

更新日期/Last Update: 2019-08-22