CHEN Qing,SUN Lei,ZOU Peng,et al.Fatigue-related biomarkers in operators of special operations forces and their correlation with occupational specialties: a pilot study [J].J Third Mil Med Univ,2019,41(11):1024-1030.

陆军特种作战军人疲劳相关生物标志物及其与岗位特征关联分析(/HTML )




Fatigue-related biomarkers in operators of special operations forces and their correlation with occupational specialties: a pilot study
陆军军医大学(第三军医大学)军事预防医学系:毒理学研究所,环境卫生学教研室; 77110部队
CHEN Qing SUN Lei ZOU Peng XIANG Peng ZHU Yuanjun ZENG Qiang LONG Gang LIU Wenbin ZHOU Ziyuan LIU Jinyi CAO Jia

Institute of Toxicology, 3Department of Environmental Health, Faculty of Military Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038; 2Troop 77110, Shifang, Sichuan Province, 618419, China

special operation training injury fatigue military training biomarkers
R446.1; R821.23; R872

目的 分析陆军特战岗位军人疲劳现状及其与岗位特征的关系。方法 在军事训练后次日上午采集某特种作战部队203名特战岗位战士静脉血和尿液。测量反映疲劳状况的相关血液指标:血红蛋白(HB)、血尿素氮(BUN)、尿酸(UA)、肌酐(CRE)、磷酸肌酸激酶(CPK)、乳酸脱氢酶(LDH)和尿液指标:微白蛋白(MAU),结合医学参考范围以及优秀运动员训练后恢复值进行分析,并与既往测量的162名非特战岗位军人(含HB、CRE、CPK、LDH指标)进行对比。比较各指标在不同岗位战士中的差异及是否存在相关性,以及各指标与过去1年中训练伤(撕裂伤、扭伤)发生情况的关联。结果 参照各指标的医学参考值范围,特战岗位军人中HB、BUN、UA、CRE、CPK、LDH及MAU分别有17.2%、2.5%、34.0%、0%、78.3%、14.3%、21.1%出现异常,参照HB、BUN、CPK、LDH的运动员恢复值,则有32.5%、0%、57.1%、11.3%的战士超标。与非特战岗位军人的HB(医学异常:1.3%;恢复超标:12.3%)和UA(医学异常:6.8%)相比,异常率明显偏高(P<0.001)。CPK、LDH、MAU等在不同特战专业间存在差异,侦察专业的多项指标在各专业中处于较高水平。CPK与UA (P=0.013)、LDH (P<0.001)、MAU (P=0.015)等指标呈正相关,CRE与BUN (P<0.001)、UA (P<0.001)呈正相关。撕裂伤或挫伤次数更多的人员中,CPK和LDH等指标的异常率也更高(P<0.05)。结论 陆军特战岗位军人中疲劳相关生物标志物超出医学参考值或恢复值的比例较高,侦察专业的疲劳状态在各专业中处于较高水平,CPK和LDH可能具有监测军人疲劳状态的应用潜力。


Objective To investigate the status of fatigue in the army special operations forces (SOF) and its relationship with occupational specialties. Methods A total of 203 operators at special positions were recruited from SOF divisions. Their fast venous blood and urine samples were collected in the next morning after regular military training. Hemoglobin (HB), blood urea nitrogen (BUN), urea acid (UA), creatine (CRE), creatine phosphokinase (CPK), lactic dehydrogenase (LDH) and microscale albuminuria (MAU) were measured and evaluated according to medical reference ranges and suitable restored limits recommended by National Bureau of Sports, so as to reflect the status of fatigue. The levels in the SOF group were compared to our data of HB, CRE, CPK and LDH levels in 162 non-SOF soldiers collected 7 years ago. The differences of the 7 biomarkers among the different SOF positions, and the correlation of these biomarkers with the occurrence of training-related injuries (strain and laceration) were analyzed. ResultsIn the SOF operators, 17.2%, 2.5%, 34.0%, 0%, 78.3%, 14.3% and 21.1% of them had abnormalities when compared with the medical reference ranges for HB, BUN, UA, CRE, CPK and LDH, respectively, and even 32.5%, 0.0%, 57.1% and 11.3% of them separately had their HB, BUN, CPK and LDH values beyond the restored values in professional athletes after exercise. There were more SOF operators having abnormal HB and UA values than the soldiers from non-SOF force (proportions beyond medical reference ranges for HB: 1.3% and UA: 6.8%, and 12.3% of them beyond the restored value)(P<0.001). Significant differences were seen in the CPK, LDH and MAU values among the operators of different SOF positions, and scouts had higher levels in multiple biomarkers. The CPK level was positively correlated with UA (P=0.013), LDH (P<0.001) and MAU (P=0.015), and that of CRE was with BUN (P<0.001) and UA (P<0.001). Among the SOF operators with repetitive strain or laceration injuries, they had higher proportions of CPK and LDH abnormalities (both P<0.05). Conclusion There are large proportion of the SOF operators having abnormal multiple biomarkers for fatigue status when compared with the medical references and the returned values in professional athletes after exercise. The fatigue status of scouts is at a high level in all specialties, and CPK and LDH may have potential to monitor the fatigue status in them.


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更新日期/Last Update: 2019-06-06