[1]孔锐,李奉,郑林鹏,等.外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值[J].第三军医大学学报,2019,41(13):1261-1266.
 KONG Rui,LI Feng,ZHENG Linpeng,et al.Predictive value of peripheral blood neutrophil to lymphocyte ratio in radiotherapeutic efficacy for NSCLC patients[J].J Third Mil Med Univ,2019,41(13):1261-1266.
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外周血中性粒细胞与淋巴细胞比率对NSCLC患者放疗效果的预测价值(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
41卷
期数:
2019年第13期
页码:
1261-1266
栏目:
临床医学
出版日期:
2019-07-15

文章信息/Info

Title:
Predictive value of peripheral blood neutrophil to lymphocyte ratio in radiotherapeutic efficacy for NSCLC patients
作者:
孔锐李奉郑林鹏孙建国
陆军军医大学(第三军医大学)第二附属医院全军肿瘤研究所
Author(s):
KONG Rui LI Feng ZHENG Linpeng SUN Jianguo

Cancer Institute of PLA, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China
 

关键词:
非小细胞肺癌NLR&DeltaNLR放射治疗
Keywords:
non-small cell lung cancer neutrophil to lymphocyte ratio &DeltaNLR radiotherapy
分类号:
R730.43; R730.55; R734.2
文献标志码:
A
摘要:

目的探讨放疗前后外周血中性粒细胞与淋巴细胞比率(neutrophil to lymphocyte ratio,NLR)及其变化(ΔNLR)对晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者放疗效果的预测价值。方法回顾性分析2011年3月至2016年5月本院行单纯放疗有完整随访资料的70例晚期NSCLC患者的临床资料,近期疗效分放疗敏感(PR+CR)组和非敏感(SD+PD)组,远期疗效以中位PFS为临界值分两组,分别检测各组放疗前后的血常规。以中位NLR为临界值分为高低两组,以放疗后NLR升高或降低分组,分别对比各组近期疗效的差别。结果放疗前NLR及其他血细胞指标与放疗敏感性、无进展生存期(progression-free survival,PFS)无相关性(P>0.05)。放疗后NLR、ΔNLR与近期疗效呈负相关(P<0.05),而与PFS无明显相关;放疗后NLR中位值为4.93,当NLR<4.93时,客观缓解率(ORR)为69%,NLR≥4.93时,ORR为37%;与放疗前比较,放疗后NLR降低(ΔNLR<0)组ORR为71%,而放疗后NLR升高(ΔNLR≥0)组ORR为45%。放疗后PLR、MLR及ΔPLR、ΔMLR也与近期疗效呈负相关(P<0.05),且放疗后PLR、MLR与NLR存在一致性,ΔPLR、ΔMLR与ΔNLR存在一致性(r>0.5,P<0.001)。结论放疗后的NLR、ΔNLR可作为与放疗近期疗效相关的预测指标。

Abstract:

ObjectiveTo investigate the predictive value of neutrophil to lymphocyte ratio (NLR) in the peripheral blood  and its changes (ΔNLR) after radiotherapy in advanced non-small cell lung cancer (NSCLC) patients. MethodsThe clinical data of 70 patients with advanced NSCLC who received simple radiotherapy in our hospital from March 2011 to June 2016 with complete follow-up data were retrospectively analyzed. The patients were divided into 2 groups based on the short-term efficacy: the radiotherapy sensitivity (PR+CR) group and non-sensitivity (SD+PD) group. They were also divided into 2 groups based on the long-term efficacy with median progression-free survival (PFS) as the critical value. Blood routine test was carried out before and after radiotherapy, and the results was compared between the 2 groups. Then with NLR as the critical value, the patients were divided into 2 groups. Differences in short-term efficacy were compared between those with increased NLR and those with decreased NLR. ResultsBefore radiotherapy, NLR and other blood cell parameters had no correlation with radiosensitivity or PFS (P>0.05). After radiotherapy, NLR and ΔNLR were negatively correlated with short-term efficacy (P<0.05), but was not correlated with PFS. After radiotherapy, NLR median value was 4.93, and objective response rate (ORR) was 69% when NLR <4.93; and was 37% when ≥4.93. In the group with decreased NLR (ΔNLR<0) after radiotherapy, ORR was 71%; in the group with increased NLR (ΔNLR≥0) after radiotherapy, ORR was 45%. Platelet to lymphocyte ratio (PLR), monocytes to lymphocyte ratio (MLR), ΔPLR and ΔMLR were also negatively correlated with short-term efficacy after radiotherapy (P<0.05), and PLR, MLR and NLR were consistent, while ΔPLR, ΔMLR and ΔNLR were also consistent after radiotherapy (r>0.5, P<0.001). ConclusionAfter radiotherapy both NLR and ΔNLR can be used as predictive indicators for the short-term efficacy of radiotherapy in NSCLC patients.

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更新日期/Last Update: 2019-07-08