[1]吴同,冉柳毅,靳佳佳,等.脑源性神经营养因子基因和神经营养性酪氨酸激酶受体Ⅱ型基因交互作用与青年自杀未遂行为的关系[J].第三军医大学学报,2019,41(11):1065-1069.
 WU Tong,RAN Liuyi,JIN Jiajia,et al.Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents [J].J Third Mil Med Univ,2019,41(11):1065-1069.
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脑源性神经营养因子基因和神经营养性酪氨酸激酶受体Ⅱ型基因交互作用与青年自杀未遂行为的关系(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
41卷
期数:
2019年第11期
页码:
1065-1069
栏目:
基础医学
出版日期:
2019-06-15

文章信息/Info

Title:
Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents
 
作者:
吴同冉柳毅靳佳佳王苏亚刘微艾明陈建梅况利
重庆医科大学附属大学城医院心理卫生中心;重庆医科大学附属第一医院心理卫生中心
Author(s):
WU Tong RAN Liuyi JIN Jiajia WANG Suya LIU Wei AI Ming CHEN Jianmei KUANG LI  

Center for Mental Health, University-Town Hospital of Chongqing Medical University, Chongqing, 401331; 2Center for Mental Health, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

关键词:
自杀未遂脑源性神经营养因子神经营养性酪氨酸激酶受体Ⅱ型基因-基因交互作用青年  
Keywords:
suicide attempt brain-derived neurotrophic factor neurotrophic tyrosine kinase receptor type 2 gene-gene interaction middle and later adolescents
分类号:
R181.23; R394.1; R749.91
文献标志码:
A
摘要:

目的 探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)基因与神经营养性酪氨酸激酶受体2型(neurotrophic tyrosine kinase receptor type 2,NTRK2)基因交互作用与青年自杀未遂行为的关系。方法 使用IMLDRtm多重SNP分型技术对病例组(70例自杀未遂青年人)和对照组(112例健康青年人)的BDNF基因1个多态性位点rs1491851和NTRK2基因3个多态性位点rs1147198、rs11140800、rs1565445进行分型,采用广义多因子降维法(generalized multifactor dimensionality reduction,GMDR)分析基因-基因交互作用。结果 在病例组与对照组中,BDNF rs1491851、NTRK2 rs1147198、rs11140800、rs1565445基因型频率与等位基因频率的分布差异均无统计学意义(P>0.05)。GMDR分析结果显示,BDNF基因与NTRK2基因的2~4阶交互作用,分别为两位点模型(rs1491851、rs1147198)、三位点模型(rs1491851、rs1147198、rs11140800)和四位点模型(rs1491851、rs1147198、rs11140800、rs1565445)。其中四位点模型(rs1491851、rs1147198、rs11140800、rs1565445,测试样本精度为0.632 5,交叉一致性检验为10/10,1 000次置换检验P值为0.032~0.033)为最佳模型。结论 BDNF基因与NTRK2基因存在交互作用,可能与青年自杀未遂行为相关。
 

Abstract:

Objective To investigate the association of the interaction between brain-derived neurotrophic factor (BDNF) gene and neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene with suicide attempt in adolescents. Methods One single nucleotide polymorphism (SNP) of BDNF gene (rs1491851) and 3 SNPs of NTRK2 (rs1147198, rs11140800, rs1565445) were tested by IMLDRtm multiplex SNP typing in 70 suicide attempters (15~24 years old) and 111 healthy young individuals (control). Analysis on gene-gene interaction was conducted by generalized multifactor dimensionality reduction (GMDR). Results No significant differences were found in genotype frequencies and allele frequencies between the attempters and controls at 4 SNPs (BDNF rs1491851, and NTRK2 rs1147198, rs1140800, rs1565445)(P>0.05). GMDR analysis indicated the interactions between BDNF gene and NTRK2 gene included a two-locus combination (rs1491851, rs1147198), a three-locus combination (rs1491851, rs1147198, rs11140800) and four-locus combination (rs1491851, rs1147198, rs11140800, rs1565445). The four-locus combination was identified as the best model (Bal. Acc. CV test: 0.632 5, CVC consistency: 10/10, permutation test: P=0.032~0.033). Conclusion There are interactions between BDNF gene and NTRK2 gene, which may be associated with suicide attempt in adolescents.

 

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更新日期/Last Update: 2019-06-06