[1]刘渝,李力,陈建昆,等.高危型人乳头瘤病毒与鳞状细胞癌抗原对宫颈癌患者术后复发的预测价值[J].第三军医大学学报,2018,40(11):1033-1037.
 LIU Yu,LI Li,CHEN Jiankun,et al.Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer[J].J Third Mil Med Univ,2018,40(11):1033-1037.
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高危型人乳头瘤病毒与鳞状细胞癌抗原对宫颈癌患者术后复发的预测价值(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第11期
页码:
1033-1037
栏目:
临床医学
出版日期:
2018-06-15

文章信息/Info

Title:
Predictive value of HR-HPV and SCC-Ag assessment during follow-up for recurrence of postoperative cervical cancer
作者:
刘渝李力陈建昆郭建新韩健郑秀惠
陆军军医大学(第三军医大学)第三附属医院(野战外科研究所)妇产科
Author(s):
LIU Yu LI Li CHEN Jiankun GUO Jianxin HAN Jian ZHENG Xiuhui

Department of Obstetrics and Gynecology, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China

关键词:
宫颈癌高危型人乳头瘤病毒鳞状细胞癌抗原复发
Keywords:
cervical cancer high-risk human papilloma virus squamous cell carcinoma antigen recurrence
分类号:
R373.9; R730.43; R737.33
文献标志码:
A
摘要:

目的    探讨高危型人乳头瘤病毒(highrisk human papilloma virus,HR-HPV)及鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)在宫颈癌患者术后随访中预测复发的价值。方法    收集2012年1月至2016年12月本科行手术治疗的宫颈癌患者406例,定期随访HRHPV及SCC-Ag值,分析HR-HPV、SCC-Ag值与复发的关系,单独检测HR-HPV、SCC-Ag值与联合检测的差异。结果    宫颈癌复发患者HR-HPV持续阳性率高于未复发患者(P<0.001),复发患者SCC-Ag阳性率高于未复发患者(P<0.001);盆腔复发患者HRHPV持续阳性率高于远处转移(P<0.05),盆腔复发与远处转移两组间SCC-Ag阳性率比较差异无统计学意义(P>0.05);单独检测HRHPV预测宫颈癌复发的灵敏度高(57.9%),单独检测SCC-Ag特异度高(95.1%),差异有统计学意义(P<0.05);联合检测HRHPV和SCC-Ag(76.3%)较单独检测灵敏度高(P<0.05)。结论    HR-HPV及SCC-Ag值均可一定程度预警宫颈癌术后复发,两者联合检测可提高检出灵敏度。

Abstract:

Objective    To explore the value of predicting recurrence of postoperative cervical cancer by monitoring high-risk human papilloma virus (HR-HPV) and squamous cell carcinoma antigen (SCC-Ag) during followingup. Methods    A total of 406 women who underwent radical or subtotal hysterectomy, or cervical conization or radical trachelectomy due to cervical cancer in our department from January 2012 to December 2016 were prospectively enrolled in this study. During the routine follow-up, HR-HPV and SCC-Ag assessment was performed. The relationship of recurrence with HR-HPV and SCC-Ag was analyzed, and the differences of single detection and joint detection were compared in the prediction of recurrence. Results    Compared those unrecurrent patients, those recurrent had higher HR-HPV persistent positive rate (P<0.001), and higher positive rate of SCC-Ag (P<0.001). The patients with pelvic recurrence had a higher persistent positive rate of HR-HPV than those with distant metastasis (P<0.05), but no such difference was seen in the positive rate of SCC-Ag between those with recurrence and with distant metastasis (P>0.05). In the prediction of recurrence of cervical cancer, single detection of HR-HPV had higher sensitivity (57.9%), and single detection of SCCAg showed higher specificity (95.1%)(both P<0.05). Whereas, joint detection of HR-HPV and SCC-Ag obtained higher sensitivity (76.3%) than single detection (P<0.05). Conclusion    Assessment of HR-HPV and SCC-Ag during following-up can warn the recurrence of cervical cancer in a certain extent, and joint detection can improve the sensitivity of prediction.

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更新日期/Last Update: 2018-06-14