[1]蔡江文,熊宇,朱礼国,等.不同牙硬组织成分的太赫兹时域光谱特征研究[J].第三军医大学学报,2018,40(11):1048-1052.
 CAI Jiangwen,XIONG Yu,ZHU Liguo,et al.Properties of human dental hard tissues by THz-SDs transmission system[J].J Third Mil Med Univ,2018,40(11):1048-1052.
点击复制

不同牙硬组织成分的太赫兹时域光谱特征研究(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第11期
页码:
1048-1052
栏目:
生物医学工程
出版日期:
2018-06-15

文章信息/Info

Title:
Properties of human dental hard tissues by THz-SDs transmission system
作者:
蔡江文熊宇朱礼国钟森城寇婷婷崔岳朱璨周继祥
陆军军医大学(第三军医大学)第一附属医院口腔科;中国工程物理研究院流体力学研究所
Author(s):
CAI Jiangwen XIONG Yu ZHU Liguo ZHONG Sencheng KOU Tingting CUI Yue ZHU Can ZHOU Jixiang

Department of Stomatology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038; Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan Province, 621900, China

关键词:
太赫兹光谱技术牙硬组织折射率吸收系数
Keywords:
Terahertz spectroscopy hard dental tissue refractive index absorption coefficient
分类号:
R312; R322.41
文献标志码:
A
摘要:

目的    应用太赫兹时域光谱技术探索透射模式下不同牙体硬组织成分的太赫兹物理特性,寻找最佳成像参数和成像频段。方法    收集陆军军医大学第一附属医院口腔科因阻生需拔除的完整无龋人第三磨牙,制备带有正常牙釉质和牙本质结构的近远中向牙磨片共15枚,序列水砂纸打磨并抛光至相同厚度。在透射模式下,利用太赫兹时域光谱技术分析计算0.2~1.3 THz频段内的吸收系数、折射率和其比值,并获取相应的曲线。结果    ①牙釉质和牙本质吸收系数在0.3、0.5和0.6 THz频率上差异有统计学意义(P<0.05);②牙釉质和牙本质的折射率在0.2~1.3频段内差异有统计学意义(P<0.05);③利用折射率更加适合于牙硬组织的成像,并在0.3 THz处具有最佳对比能力。结论    太赫兹技术可用于辨识牙釉质和牙本质,且折射率更加适合于牙体硬组织成像,在0.3 THz处牙釉质和牙本质的折射率对比度最大。
 

Abstract:

Objective    To explore the spectroscopical properties of human normal enamel and dentine by Terahertz time-domain spectroscopy (THz-SDs) transmission system, and to investigate the best parameter and frequency for imaging. Methods    Fifteen intact third molars were freshly extracted and sliced mesiodistally to 0.7 mm in thickness, and ground serially with sand-papers under running tap water. Terahertz spectrum of enamel and dentin were obtained with the THz-SDs, and then the absorption coefficient, refractive index and refractive index ratio of the dental hard tissues were calculated in the frequency of 0.2 to 1.3 THz. Results    ①The absorption coefficient of enamel was statistically significantly different with that of dentin at 0.3, 0.5 and 0.6 THz (P<0.05); ② Obvious differences were also observed in the refractive index between enamel and dentin at the range of 0.2~1.3 THz (P<0.05); ③ Since the refractive index may be more suitable to image the human dental hard tissue, and 0.3 THz was chosen to get the best contrast. Conclusion     Terahertz can be used to identify enamel and dentin, and refractive index is more suitable to image dental hard tissue. At 0.3 THz, the refractive index contrast of enamel and dentin is the largest.

参考文献/References:

[1]CRAWLEY D A,LONGBOTTOM C,COLE B E,et al. Terahertz pulse imaging: a pilot study of potential applications in dentistry[J]. Caries Res, 2003, 37(5):352-359.DOI:10.1159/000072167.
[2]朱新建,何璇,王品,等.太赫兹成像技术应用于烧伤检测的研究发展[J]. 生物医学工程学杂志,2016,33(1):184-187. DOI:10.7507/10015515.20160033.
ZHU X J,HE X,WANG P, et al. Development of Terahertz imaging technology in the assessment of burn injuries[J].J Biomed Eng,2016,33(1):184-187.DOI:10.7507/10015515.20160033.
[3]张明月,吴岩印,肖征.太赫兹在医学检测中的应用和进展[J]. 医疗卫生装备, 2013, 34(5): 84-86.DOI:10.7687/J.ISSN 10038868.2013.05.084.
ZHANG M Y,WU Y Y,XIAO Z.Application and progress of Terahertz in medical detection[J].Chin Med Equip J, 2013, 34(5): 84-86.DOI:10.7687/J.ISSN 10038868.2013.05.084.
[4]胡梦博,董菲,丁强.太赫兹技术在泌尿系统疾病应用的研究进展与展望[J]. 中华医学杂志,2014,94(32):2557-2559.DOI:10.3760/cma.j.issn.03762491.2014.32.018.
HU M B,DONG F,DING Q.Progress and prospect of Terahertz technology in the application of urinary system diseases[J].Natl Med J China,2014,94(32):2557-2559.DOI:10.3760/cma.j.issn.03762491.2014.32.018.
[5]祁峰,汪业龙. 利用太赫兹技术实现皮肤癌早期精确诊断[J]. 中国医学物理学杂志, 2016, 33(12): 1195-1198.DOI:10.3969/j.issn.1005202X .2016.12.002.
QI F,WANG YL.Terahertz technology utilized to achieve early accurate diagnosis of skin cancer[J].Chin J Med Phys, 2016, 33(12): 1195-1198. DOI:10.3969/j.issn.1005202X .2016.12.002.
[6]SIM Y C, MAENG I,SON J. Frequencydependent characteristics of terahertz radiation on the enamel and dentin of human tooth[J]. Current Appl Phys, 2009, 9(5): 946-949.DOI:10.1016/j.cap.2008.09.008.
[7]SUN Q, HE Y, LIU K,et al.Recent advances in terahertz technology for biomedical applications[J].Quant Imaging Med Surg,2017, 7(3):345-355.DOI:10.21037/qims.2017.06.02.
[8]刘丁瑗,施长城,周向东.太赫兹光谱技术用于肺癌检测的初步探索研究[J].第三军医大学学报,2017,39(17):1739-1743.DOI:10.16016/j.10005404.201702014.
LIU D Y,SHI C C,ZHOU X D.Terahertz spectroscopy for lung cancer detection:a preliminary study[J]. J Third Mil Med Univ, 2017,39(17):1739-1743.DOI:10.16016/j.10005404.201702014.
[9]MENG K, CHEN T N, CHEN T, et al. Terahertz pulsed spectroscopy of paraffinembedded brain glioma[J]. J Biomed Opt, 2014, 19(7):077001.DOI:10.1117/1.JBO.19.7.077001.
[10]LEWIS R A.太赫兹物理[M].北京:国防工业出版社,2015:197-203.
LEWIS R A.Terahertz physics[M].BeiJing:National Defense Industry Press, 2015:197-203.
[11]余闻静,杨翔,刘羽,等.不同芽孢菌的太赫兹时域光谱特征研究[J].第三军医大学学报,2017,39(13):1315-1320.DOI:10.16016/j.10005404.201703025.
YU W J,YANG X,LIU Y,et al.Characteristics of different kinds of bacillus by Terahertz timedomain spectroscopy[J].J Third Mil Med Univ, 2017,39(13):1315-1320.DOI:10.16016/j.10005404.201703025.
[12]王文爱,刘维,杨茜,等.无水葡萄糖的太赫兹时域光谱特性[J].中国激光,2016,43(11): 235-242.DOI:10.3788/CJL201643.1111001.
WANG W A,LIU W,YANG X.et al.Terahertz timedomain spectroscopy of anhydrous glucose[J].Chin J Lasers, 2016,43(11):235-242.DOI:10.3788/CJL201643.1111001.
[13]YANG X, ZHAO X, YANG K, et al. Biomedical applications of Terahertz spectroscopy and imaging[J].Trends Biotechnol, 2016, 34(10):810-824.DOI:10.1016/j.tibtech.2016.04.008.
[14]LEISSHOLZINGER E, WIESAUER K,STEPHANI H,et al.Imaging of the inner structure of cave bear teeth by novel nondestructive techniques[J]. Palaeontol Electron,2015,18(1):1-15.DOI:10.26879/489.
[15]GOMEZ J. Detection and diagnosis of the early caries lesion[J]. BMC Oral Health, 2015,15(Suppl 1):S3.DOI:10.1186/1472-683115S1S3.
[16]于世凤.口腔组织病理学[M].北京:人民卫生出版社,2012:53,63.
封YU S F.Oral histopathology[M].Beijing:People’s Medical Publishing House, 2012:53,63.
[17]韩毓旺,侯亚义,都有为.生物电磁特性与电磁生物学效应的概述及最新进展[J].自然杂志,2010,32(6):319-325,331.DOI:10.3969/j.issn02539608.2010.06.003.
HAN Y W,HOU Y Y, DU Y W.Overview of electromagnetic properties of life and electromagnetic biological effects and their latest progress[J].Chin J Nature, 2010,32(6):319-325,331.DOI:10.3969/J.ISSN02539608.2010.06.003.

更新日期/Last Update: 2018-06-14