[1]胡然,王萍,陈奇权,等.T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值[J].第三军医大学学报,2018,40(06):528-531.
 HU Ran,WANG Ping,CHEN Qiquan,et al.Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients[J].J Third Mil Med Univ,2018,40(06):528-531.
点击复制

T-SPOT.TB检测对诊治结核感染相关脂膜炎患者的价值(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第06期
页码:
528-531
栏目:
临床医学
出版日期:
2018-03-30

文章信息/Info

Title:
Clinical significance of T-SPOT.TB for diagnosis and treatment of tuberculosis in panniculitis patients
作者:
胡然王萍陈奇权钟白玉宋志强郝飞
陆军军医大学(第三军医大学)第一附属医院皮肤科
Author(s):
HU Ran WANG Ping CHEN Qiquan ZHONG Baiyu SONG Zhiqiang HAO Fei

Department of Dermatology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China

关键词:
T-SPOT.TB检测脂膜炎结核感染
Keywords:
T-SPOT.TB assay panniculitis tuberculosis infection
分类号:
R378.911;R446.5;R758.69
文献标志码:
A
摘要:

目的    探索结核感染T细胞斑点试验 (TSPOT.TB) 检测用于脂膜炎患者中结核感染病因分析的价值。方法    回顾性分析2011-2013年我院159例病理诊断为脂膜炎并进行T-SPOT.TB检测的患者的临床及组织病理资料,并对其中的92名患者进行3年的随访,31名健康人作研究对照。结果    脂膜炎中T-SPOT.TB检查阳性率为76.1%,显著高于正常人群(9.7%,P<0001);抗结核治疗患者有效率为75.3%,复发率为20.0%,其中完成6个月疗程的患者复发率显著低于3个月内停药的患者(P<005)。结论    T-SPOT.TB检测对于查找结核感染相关的脂膜炎患者有一定的价值。

Abstract:

Objective   To explore the significance of T-SPOT.TB assay in the etiological analysis for panniculitis patients. Methods    We retrospectively reviewed the clinical and histopathological features of 159 cases of panniculitis diagnosed in our hospital who underwent T-SPOT.TB assay from January 2011 to December 2013. And 92 cases of them were followed up by telephone for 3 years. Another 31 health individuals served as normal control. Results    The overall positive rate to T-SPOT.TB assay was 76.1% in the panniculitis patients, significantly higher than that of healthy subjects (9.7%, P<0.001). The overall effective rate was 75.3% for anti-tuberculosis treatment, and the recurrence rate was 20.0%. The patients who accomplished treatment course of 6 months had obviously lower recurrent rate than those who only have in 3 months’ treatment (P<0.05). Conclusion    T-SPOT.TB assay is valuable to detect the tuberculosis infection in panniculitis patients.

参考文献/References:

[1]REQUENA L, SáNCHEZ YUS E. Panniculitis. Part I. Mostly septal panniculitis[J]. J Am Acad Dermatol, 2001, 45(2): 163-183. DOI: 10.1067/mjd.2001.114736.
[2]REQUENA L, SáNCHEZ YUS E. Panniculitis. Part Ⅱ. Mostly lobular panniculitis[J]. J Am Acad Dermatol, 2001, 45(3): 325-361. DOI: 10.1067/mjd.2001.114735.
[3]GILCHRIST H, PATTERSON J W. Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management[J]. Dermatol Ther, 2010, 23(4): 320-327. DOI: 10.1111/j.15298019.2010.01332.x.
[4]XU K, DING C, MANGAN C J, et al. Tuberculosis in China: A longitudinal predictive model of the general population and recommendations for achieving WHO goals[J]. Respirology, 2017, 22(7): 1423-1429. DOI: 10.1111/resp.13078.
[5]HU Y, ZHAO Q, GRAVISS E A, et al. Use of the TSPOT.TB assay to screen latent tuberculosis infection among the TB contacts in Shanghai, China[J]. J Infect, 2012, 65(1): 39-48. DOI: 10.1016/j.jinf.2012.03.018.
[6]刘琳, 王敬亚, 祖蓓蓓, 等. TSPOT.TB试验对240例疑似结核患者的诊断分析[J]. 中华临床医师杂志(电子版), 2016, 10(3): 440-442.
LIU L, WANG J Y, ZU B B, et al. Diagnosis value of TSPOT.TB test for 240 cases of suspected tuberculosis [J]. Chin J Clinicians (Electronic Ed), 2016, 10(3): 440-442.
[7]MCKEE P H, CALONJE E, GRANTER S R. 皮肤病理学: 与临床的联系[M]. 朱学骏, 孙建方, 译. 3版. 北京: 北京大学医学出版社, 2005: 341-384.
MCKEE P H, CALONJE E, GRANTER S R. Pathology of the skin: with clinical correlation[M]. ZHU X J, SUN J F, translated. 3rd ed. Beijing: Peking University Medical Press, 2005: 341-384.
[8]肖东楼, 赵明刚, 王宇. 中国结核病防治规划实施工作指南(2008年版)[M]. 北京: 中国协和医科大学出版社, 2009.
XIAO D L, ZHAO M G, WANG Y. Guidelines for implementation of tuberculosis prevention and control plan in China (2008)[M]. Beijing: Beijing Union Medical University Press, 2009.
[9]SCHWARTZ R A, NERVI S J. Erythema nodosum: a sign of systemic disease[J]. Am Fam Physician, 2007, 75(5): 695-700.
[10]MERT A, KUMBASAR H, OZARAS R, et al. Erythema nodosum: an evaluation of 100 cases[J]. Clin Exp Rheumatol, 2007, 25(4): 563-570.
[11]WHITWORTH H S, SCOTT M, CONNELL D W, et al. IGRAs—the gateway to T cell based TB diagnosis[J]. Methods, 2013, 61(1): 52-62. DOI: 10.1016/j.ymeth.2012.12.012.
[12]GETAHUN H, MATTEELLI A, CHAISSON R E, et al. Latent Mycobacterium tuberculosis infection[J]. N Engl J Med, 2015, 372(22): 2127-2135. DOI: 10.1056/NEJMra1405427.

更新日期/Last Update: 2018-03-23