[1]戴伊奇,王书楠,国巍,等.硼替佐米治疗人免疫缺陷病毒阴性浆母细胞淋巴瘤3例报告并文献复习[J].第三军医大学学报,2018,40(04):334-339.
 DAI Yiqi,WANG Shunan,GUO Wei,et al.Bortezomib in treatment of HIV-negative plasmablastic lymphoma: report of 3 cases and literature review[J].J Third Mil Med Univ,2018,40(04):334-339.
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硼替佐米治疗人免疫缺陷病毒阴性浆母细胞淋巴瘤3例报告并文献复习(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
40卷
期数:
2018年第04期
页码:
334-339
栏目:
临床医学
出版日期:
2018-02-28

文章信息/Info

Title:
Bortezomib in treatment of HIV-negative plasmablastic lymphoma: report of 3 cases and literature review
作者:
戴伊奇王书楠国巍白鸥
吉林大学第一医院肿瘤中心血液科
Author(s):
DAI Yiqi WANG Shunan GUO Wei BAI Ou

Department of Hematology, Cancer Center, First Hospital of Jilin University, Changchun, Jilin Province, 130021, China

关键词:
浆母细胞淋巴瘤硼替佐米人免疫缺陷病毒
Keywords:
plasmablastic lymphoma bortezomib human immunodeficiency virus
分类号:
R733.4;R979.1
文献标志码:
A
摘要:

目的    提高对人免疫缺陷病毒(human immunodeficiency virus,HIV)阴性浆母细胞淋巴瘤(plasmablastic lymphoma,PBL)的临床特征、治疗及预后的认识。方法    回顾性分析吉林大学第一医院肿瘤中心血液科2015-2016年收治的应用硼替佐米治疗的3例HIV阴性PBL患者的临床资料,分析其临床特征及转归。结果    ① 3例HIV阴性PBL患者均为男性,年龄分别为42、43、35岁;其中2例以腹部症状起病,1例以淋巴结肿大起病;均无导致免疫功能低下的疾病或状态。② 2例有结外受累,1例有骨髓受累;根据淋巴瘤Ann Arbor分期分别为ⅠA、ⅢA、ⅣB期。③病理:均表现弥漫大B细胞淋巴瘤的形态学特点;具有典型的浆细胞表型;Ki-67指数分别为80%、70%、40%。④治疗:3例均采用了以硼替佐米为基础的联合化疗方案,1例完全缓解(clinical complete response,CR),2例部分缓解(partly remission,PR),无进展生存期(progressionfree survival,PFS)分别为1、6、10个月,总生存期(overall survival,OS)分别为5个月、7个月、未获得。结论    该组人免疫缺陷病毒阴性浆母细胞淋巴瘤患者以中青年为主,疾病呈高侵袭性;临床分期为晚期及Ki67高的患者预后差;硼替佐米用于治疗浆母细胞淋巴瘤需要临床进一步观察。

Abstract:

Objective    To better understand the clinical features, treatment and prognosis of HIV-    negative plasmablastic lymphoma (PBL). Methods    The clinical data were reviewed for 3 cases of HIVnegative PBL treated with bortezomib in our department between January, 2015 and December, 2016. The clinical features and outcomes of the patients were analyzed retrospectively. Results    All these 3 patients were male and aged 42, 43, and 35 years. Two of the patients presented with gastrointestinal discomfort and the other patient had lymphadenopathy as the initial symptom. None of them had underlying immunosuppressive state. Extranodular involvement was found in 2 patients and bone marrow involvement in the other, and they were in stage Ⅳ, stage Ⅲ, and stage Ⅰ according to Ann Arbor Staging. Pathological examination revealed morphological features of diffuse large B cell lymphoma and typical immunophenotypic characteristics of plasma cells in all the 3 patients, and their Ki-67 index was 80%, 70%, and 40%. All the patients received bortezomib-based chemotherapy, and complete response was achieved in 1 patient and partial responses in the other 2. The progression-free survival of the 3 patients was 1, 6 and 10 months with overall survival of 5, 7 and over 22 months, respectively. Conclusion    The patients with HIV-negative PBL are mainly at the middle age upon disease onset. HIV-negative PBL is highly aggressive, and the patients in advanced stage or with a high Ki-67 index at the diagnosis often have a poor prognosis. The efficacy of bortezomib for treatment of PBL still needs further investigation.

相似文献/References:

[1]谢燕,喻秀丽,童立纺.硼替佐米对A549细胞增殖及p21、p27表达的影响[J].第三军医大学学报,2012,34(17):1775.
 Xie Yan,Yu Xiuli,Tong Lifang.Anti-proliferation effect of proteasome inhibitor bortezomib in human lung adenocarcinoma A549 cells[J].J Third Mil Med Univ,2012,34(04):1775.
[2]李佳丽,刘耀,曾东风,等.硼替佐米联合地塞米松和沙利度胺治疗多发性骨髓瘤的临床研究[J].第三军医大学学报,2012,34(24):2515.
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[3]杨再林,张勇,张伶,等.硼替佐米联合化疗对多发性骨髓瘤的疗效与相关血液学指标分析[J].第三军医大学学报,2010,32(09):975.
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[4]樊锐太,胡勇,刘俊启,等.硼替佐米对U87胶质瘤放射增敏及细胞周期分布的影响[J].第三军医大学学报,2012,34(08):758.
 Fan Ruitai,Hu Yong,Liu Junqi,et al.Effect of bortezomib on radiosensitivity of U87 glioma and distribution of cell cycle[J].J Third Mil Med Univ,2012,34(04):758.

更新日期/Last Update: 2018-03-03