[1]刘丁瑗,施长城,周向东.太赫兹光谱技术用于肺癌检测的初步探索研究[J].第三军医大学学报,2017,39(17):1739-1743.
 LIU Dingyuan,SHI Changcheng,ZHOU Xiangdong.Terahertz spectroscopy for lung cancer detection: a preliminary study[J].J Third Mil Med Univ,2017,39(17):1739-1743.
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太赫兹光谱技术用于肺癌检测的初步探索研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第17期
页码:
1739-1743
栏目:
临床医学
出版日期:
2017-09-15

文章信息/Info

Title:
Terahertz spectroscopy for lung cancer detection: a preliminary study
作者:
刘丁瑗施长城周向东
第三军医大学西南医院呼吸内科;中国科学院重庆绿色智能技术研究院
Author(s):
LIU Dingyuan SHI Changcheng ZHOU Xiangdong

Department of Respiratory Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China

关键词:
太赫兹光谱技术非小细胞肺癌吸收率
Keywords:
terahertz spectroscopy non-small cell lung cancer absorption rate
分类号:
O433.4; R730.49; R734.2
文献标志码:
A
摘要:

目的      利用太赫兹光谱技术,对人肺癌组织进行检测,比较肺癌组织、癌旁组织及正常肺组织之间的差异,筛选出具有特异性诊断价值的太赫兹频段,初步探索太赫兹光谱技术用于肺癌的早期检测。方法      收集2015年6月至2015年12月经我院胸外科手术切除、病理明确诊断为Ⅰ~ⅢA期非小细胞肺癌患者30例,其肺癌组织病理类型为:腺癌17例、鳞癌10例、大细胞肺癌2例、肉瘤样癌1例。每组包括同一患者肺癌组织、癌旁组织及正常肺组织。运用频段为0.2~2.0 THz的太赫兹光谱进行检测,对比3类组织标本对太赫兹光谱的吸收率。结果      ①肺癌组织对太赫兹光谱吸收率显著高于正常肺组织; ②太赫兹光谱频段1.4~2.0 THz可能为具有肺癌特异性诊断价值的太赫兹频段。结论      鉴于肺癌组织对太赫兹光谱吸收率高于正常肺组织,太赫兹光谱技术可能成为一种新型非侵入诊断肺癌的检测技术,其具有特异性诊断价值的太赫兹频段可能为1.4~2.0 THz。

Abstract:

Objective       To preliminarily explore the application of terahertz spectroscopy in the early detection of lung cancer by comparing the differences among lung cancer tissues, paracancerous tissues, and normal lung tissues with terahertz spectroscopy and screen the suitable terahertz frequency for specific diagnosis of lung cancer. Methods       Thirty groups of lung tissue samples from nonsmall cell lung cancer patients at stage of Ⅰ to ⅢA were collected, and each group contained lung cancer tissue, paracancerous tissues, and normal lung tissue from the same patient. These lung cancer specimens included 17 cases of adenocarcinoma, 10 cases of squamous cell carcinoma, 2 cases of large cell lung cancer, and 1 case of sarcomatoid carcinoma. Terahertz spectroscopy from 0.2 THz to 2.0 THz was used to detect these tissue samples, and the absorption coefficient was compared. Results       ① The absorption coefficient was significantly higher in the lung cancer tissues than the normal lung tissues. ② Terahertz spectroscopy at a frequency of 0.8 to 1.4 THz may have the specific diagnostic value of lung cancer. Conclusion      Since the absorption rate is higher in the lung cancer than the normal lung tissue, which is suggested that terahertz spectroscopy may be regarded as a novel non-invasive diagnostic approach for lung cancer. The specific diagnostic value of the terahertz frequency may be 1.4-2.0 THz for lung cancer.

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更新日期/Last Update: 2017-09-04