[1]钟英,王冬,高惠,等.不同年龄段健康儿童左心室收缩期心肌纵向应变及应变率正常参考值的初步分析[J].第三军医大学学报,2017,39(17):1750-1755.
 ZHONG Ying,WANG Dong,GAO Hui,et al.Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis[J].J Third Mil Med Univ,2017,39(17):1750-1755.
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不同年龄段健康儿童左心室收缩期心肌纵向应变及应变率正常参考值的初步分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
39卷
期数:
2017年第17期
页码:
1750-1755
栏目:
临床医学
出版日期:
2017-09-15

文章信息/Info

Title:
Normal reference values for left ventricular peak systolic longitudinal strain and strain rate in healthy children at different ages: a preliminary analysis
作者:
钟英王冬高惠吕莉梁小华杨柯汪朝霞
重庆医科大学附属儿童医院:超声科,流行病学与生物信息学研究室,儿科研究所,儿童发育疾病研究教育部重点实验室,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室
Author(s):
ZHONG Ying WANG Dong GAO Hui LYU Li LIANG Xiaohua YANG Ke WANG Zhaoxia

Department of Ultrasonography, Department of Epidemiology and Bioinformatics, 3Pediatric Research Institute, 4Key Laboratory of Child Development and Disorders of Ministry of Education, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China

关键词:
超声心动图斑点追踪成像纵向应变应变率儿童
Keywords:
echocardiography speckle tracking imaging longitudinal strain strain rate children
分类号:
R322.11; R339.31; R445.1
文献标志码:
A
摘要:

目的      应用二维斑点追踪成像技术定量分析健康儿童左心室收缩期心肌纵向应变及应变率,并进行其不同年龄段正常参考值的初步分析。方法     回顾性分析2015年9月至2016年11月来本院超声科体检的330例健康儿童的超声临床资料。按年龄分成7组,分为新生儿组(0~28 d)、婴儿组(>28 d至<1岁)、幼儿组(1~<3岁)、学龄前期组(3~<6岁)、学龄期组(6~<9岁)、青春前期组(9~<13岁)、青春期组(13~<18岁)。采用斑点追踪软件分析左心室心尖3个长轴切面的动态图像,获取左心室收缩期心肌纵向应变及应变率值。结果     ① 6室壁节段间收缩期纵向应变及应变率的差异均有统计学意义(P<0.05),且纵向应变及应变率绝对值自基底段向心尖段呈逐渐增加趋势;② 18节段应变及应变率及整体应变在不同性别间差异均无统计学意义(P>0.05);③ 除后壁、下壁、后间隔基底段外,余各室壁节段纵向应变(longitudinal strain, LS)情况为|LS新生儿组|<|LS婴儿组|<|LS幼儿、学龄前期、学龄期组|<|LS青春前期、青春期组|,且整体心肌纵向应变在年龄组间的趋势与其一致;④ 18节段应变与年龄呈正相关,以侧壁心尖段相关性最强(r=0.551,P<0.01);与心率均呈负相关,以侧壁中间段相关性最强(r=-0.517,P<0.01);整体心肌纵向应变与年龄呈正相关(r=0.665,P<0.01),与心率呈负相关(r=-0.625,P<0.01)。⑤18节段应变率与年龄、心率的相关性,以及在各年龄组间的差异存在不均一性。结论     建立了不同年龄段健康儿童左心室收缩期心肌纵向应变及应变率的正常参考值,并发现其具有自身特征。

Abstract:

Objective     To analyze the normal reference values of left ventricular longitudinal peak systolic strain (LS) and strain rate (LSr) by two-dimensional speckle tracking imaging (2D-STI) in healthy children at different ages. Methods    Clinical ultrasound data of 330 healthy children who taking physical examination in our hospital from September 2015 to November 2016 were collected and retrospectively. They were divided into 7 groups according to their ages, that is, neonate group (0 to 28 days old), infant group (28 days to 1 year old), toddle group (1 to 3 years old), pre-school group (3 to 6 years old), school age group (6 to 9 years old), pre-adolescence group (9 to 13 years old) and adolescence group (13 to 18 years old). 2D-STI was performed in the 3 apical projections of left ventricle (LV). The regional peak systolic longitudinal strain and strain rate of LV were measured. Results     ① Significant differences were found in the LS and LSr values from 6 segments of the same wall (P<0.05), and the LS and LSr values were gradually increased from basal segment to apical segment. ②There were no significant differences in the LS, LSr and global LS (GLS) values of 18 segments between sexes (P>0.05). ③ Except the basal segments of posterior wall, inferior wall and posterior septum, LS value was gradually elevated with the increase of age (LSneonate<LSinfant<LStoddler, pre-school and school age<LSpre-adolescence and adolescence), so was GLS value. ④LS in 18 segments had a positive correlation with age, and the value of apical segment in lateral wall was most remarkably correlated (r=0.551, P<0.01); Regional LS had a negative correlation with heart rate, and that of middle segment in lateral wall was the most apparent (r=-0.625, P<0.01); GLS was positively influenced by age (r=0.665, P<0.01) and negatively affected by heart rate (r=-0.625, P<0.01). ⑤The heterogeneities were found in the correlations of regional LSr with age and heart rate in segments and in the LSr among different age groups. Conclusion     Normal reference values of LV peak LS and LSr are established for healthy children at different ages, and they possess their own characteristics.

参考文献/References:

[1]GONG L, LI D, CHEN J, et al. Assessment of myocardial viability in patients with acute myocardial infarction by two-dimensional speckle tracking echocardiography combined with low-dose dobutamine stress echocardiography[J]. Int J Cardiovasc Imaging, 2013, 29(5): 1017-1028. DOI: 10.1007/s10554-013-0185-y.
[2]YU Y, VILLARRAGA H R, SALEH H K, et al. Can ischemia and dyssynchrony be detected during early stages of dobutamine stress echocardiography by 2-dimensional speckle tracking echocardiography[J]. Int J Cardiovasc Imaging, 2013, 29(1): 95-102. DOI: 10.1007/s10554-012-0074-9.
[3]KURT M, TANBOGA I H, AKSAKAL E. Two-dimensional strain imaging: basic principles and technical consideration[J]. Eurasian J Med, 2014, 46(2): 126-130. DOI: 10.5152/eajm.2014.28.
[4]CERQUEIRA M D, WEISSMAN N J, DILSIZIAN V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. a statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the american heart association[J]. Int J Cardiovasc Imaging, 2002, 18(1): 539-542. DOI: 10.1161/hc0402.102975.
[5]BUSSADORI C, MOREO A, DI DONATO M, et al. A new 2D-based method for myocardial velocity strain and strain rate quantification in a normal adult and paediatric population: assessment of reference values[J]. Cardiovasc Ultrasound, 2009, 7: 8. DOI:10.1186/1476-7120-7-8.
[6]RECKEFUSS N, BUTZ T, HORSTKOTTE D, et al. Evaluation of longitudinal and radial left ventricular function by twodimensional speckletracking echocardiography in a large cohort of normal probands[J]. Int J Cardiovasc Imaging, 2011, 27(4): 515-526. DOI: 10.1007/s10554-010-9716-y.
[7]姜岚, 谢明星, 王新房, 等. 正常儿童左心室斑点追踪成像纵向应变研究[J]. 中华超声影像学杂志, 2009, 18(4): 298-301. DOI: 10.3760/cma.j.issn.10044477.2009.04.010.
JIANG L,XIE M X, WANG X F, et al. Evaluation of left ventricular systolic longitudinal strain in healthy children by two dimensional speckle tracking imaging[J]. Chin J Ultrasonogr , 2009, 18(4): 298-301. DOI:10.3760/cma.j.issn.10044477.2009.04.010.
[8]PENA J L, DA SILVA M G, FARIA S C, et al. Quantification of regional left and right ventricular deformation indices in healthy neonates by using strain rate and strain imaging[J]. J Am Soc Echocardiogr, 2009, 22(4): 369-375. DOI: 10.1016/j.echo.2008.12.007.
[9]RUSHMER R F, CRYSTAL D K, WAGNER C. The functional anatomy of ventricular contraction[J]. Circ Res, 1953, 1(2): 162-170. DOI:10.1161/01.res.1.2.162.
[10]Brecker S J. The importance of long axis ventricular function[J]. Heart, 2000, 84(6): 577-579. DOI: 10.1136/heart.84.6.577.
[11]MARCUS K A, MAVINKURVE-GROOTHUIS A M, BARENDS M, et al. Reference values for myocardial two-dimensional strain echocardiography in a healthy pediatric and young adult cohort[J]. J Am Soc Echocardiogr, 2011, 24(6): 625-636. DOI: 10.1016/j.echo.2011.01.021.
[12]WULFSOHN D, NYENGAARD J R, TANG Y. Postnatal growth of cardiomyocytes in the left ventricle of the rat[J]. Anat Rec A Discov Mol Cell Evol Biol, 2004, 277(1): 236-247. DOI: 10.1002/ar.a.20009.
[13]SIEDNER S, KRUGER M, SCHROETER M, et al. Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart[J]. The Journal of Physiology, 2003, 548(2): 493-505. DOI: 10.1113/jphysiol.2002.036509.
[14]BISI G, PODIO V, VALETTO M R, et al. Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GHreleasing peptide, in humans[J]. J Endocrinol Invest, 1999, 22(4): 266-272. DOI: 10.1007/BF03343555.
[15]姜岚, 谢明星, 王新房, 等. 超声斑点追踪成像技术评价正常儿童左心室局部心肌收缩期纵向应变率研究[J]. 中华临床医师杂志(电子版), 2011, 5(23): 6884-6891. DOI: 10.3877/cma.j.issn.16740785.2011.23.005.
JIANG L, XIE M X, WANG X F, et al. Quantification of regional left ventricular longitudinal strain rate in healthy children by speckle tracking echocardiography[J]. Chin J Clinicians(Electronic Edition), 2011, 5(23): 6884-6891. DOI: 10.3877/cma.j.issn.16740785.2011.23.005.
[16]TAKIGIKU K, TAKEUCHI M, IZUMI C, et al. Normal range of left ventricular 2dimensional strain: japanese ultrasound speckle tracking of the left ventricle (JUSTICE) study[J]. Circ J, 2012, 76(11): 2623-2632.

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更新日期/Last Update: 2017-09-05