[1]陈静,李延萍.特发性快动眼期睡眠行为异常非运动障碍的特点[J].第三军医大学学报,2016,38(22):2462-2465.
 Chen Jing,Li Yanping.Characteristics of nondyskinesias in idiopathic REM sleep disorder[J].J Third Mil Med Univ,2016,38(22):2462-2465.
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特发性快动眼期睡眠行为异常非运动障碍的特点(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
38卷
期数:
2016年第22期
页码:
2462-2465
栏目:
临床医学
出版日期:
2016-11-30

文章信息/Info

Title:
Characteristics of nondyskinesias in idiopathic REM sleep disorder
作者:
陈静李延萍
重庆市中医院脑病科
Author(s):
Chen JingLi Yanping

Department of Brain Disease, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China

关键词:
特发性快动眼期睡眠行为异常非运动障碍帕金森病
Keywords:
idiopathic REM sleep disordernon-dyskinesiasParkinson&rsquos disease
分类号:
R338.63;R339.141;R741
文献标志码:
A
摘要:

目的      通过分析快动眼期睡眠行为异常(idiopathic REM sleep disorder,iRBD)患者是否存在嗅觉减退、睡眠障碍、焦虑抑郁,来探讨iRBD患者的非运动障碍特点。方法     收集我院2014年1月至2016年1月iRBD患者48例及健康对照组53例,分别对两组人群进行睡眠指标、嗅觉功能、焦虑抑郁量表以及血清中IL-6、TNF-α浓度的检测。结果     iRBD组与健康对照组比较,其总睡眠时间、睡眠效率明显降低(P<0.05);睡眠潜伏期、觉醒指数、快动眼睡眠潜伏期明显增高(P<0.05);嗅觉减退明显增多(P<0.01);焦虑抑郁评分明显增高(P<0.05);但两组人群血清中IL-6及TNF-α浓度差异没有统计学意义(P>0.05)。结论      iRBD与帕金森病有类似的非运动障碍特点,早期干预iRBD人群有利于帕金森病患者的预防和治疗。

Abstract:

Objective      To study the characteristics of non-dyskinesias in (idiopathic REM sleep disorder, iRBD) patients by examining the possible symptoms of hyposmia, sleep disorders, anxiety and depression. Methods      Forty-eight iRBD patients and 53 healthy people recruited from our hospital between Jan 2014 and Jan 2016 were studied as treatment and control groups. The subjects of the 2 groups were evaluated by factors including sleep indicators, olfactory function, anxiety and depression scale, and blood serum concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Results      Compared with control group, total sleep time and sleep efficiency were significantly reduced in treatment group (P<0.05). Also, sleep latency, awakening index and rapid eye movement (REM) sleep latency were significantly increased (P<0.05), along with more severe hyposmia and higher score of anxiety and depression in the treatment than control group (P<0.05). But there were no significant differences in the serum levels of IL-6 and TNF-α between the 2 groups(P>0.05). Conclusion     Patients with iRBD or Parkinson’s disease (PD) share similar symptoms of non-dyskinesias. Early intervention in iRBD patients will be of benefit to prevent and treat patients with PD.

参考文献/References:

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更新日期/Last Update: 2016-11-23