[1]谭顺,刘奉凤,刘敏,等.重庆市1 978例初始接受抗逆转录病毒治疗HIV感染者的回顾性分析[J].第三军医大学学报,2016,38(19):2190-2194.
 Tan Shun,Liu Fengfeng,Liu Min,et al.A retrospective analysis of HIV-infected patients receiving initial antiretroviral therapy: report of 1 978 cases from Chongqing region[J].J Third Mil Med Univ,2016,38(19):2190-2194.
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重庆市1 978例初始接受抗逆转录病毒治疗HIV感染者的回顾性分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
38卷
期数:
2016年第19期
页码:
2190-2194
栏目:
临床医学
出版日期:
2016-10-15

文章信息/Info

Title:
A retrospective analysis of HIV-infected patients receiving initial antiretroviral therapy: report of 1 978 cases from Chongqing region
作者:
谭顺刘奉凤刘敏李奇穗袁婧陈耀凯
重庆市公共卫生医疗救治中心感染二科
Author(s):
Tan Shun Liu Fengfeng Liu Min Li Qisui Yuan Jing Chen Yaokai

Second Department of Infections Disease, Chongqing Public Health Medical Center, Chongqing, 400036, China

关键词:
人类免疫缺陷病毒获得性免疫缺陷综合征抗逆转录病毒治疗临床特征回顾性分析
Keywords:
human immunodeficiency virus acquired immunodeficiency syndrome antiretroviral therapy clinical features retrospective analysis
分类号:
R195.4; R512.91
文献标志码:
A
摘要:

目的      了解重庆市人类免疫缺陷病毒(human immunodeficiency virus, HIV)感染者临床特征及影响疾病进展的危险因素。方法      收集2013-2015年在重庆市公共卫生医疗救治中心接受初始抗逆转录病毒治疗(antiretroviral therapy, ART)治疗的HIV感染者临床资料,根据病情对基本资料、临床检测指标、合并疾病进行回顾性分析。结果      1 978例初始接受ART治疗的HIV感染者中,54.9%的患者在ART治疗前病情进入艾滋病期,90%以上HIV感染者CD4+淋巴细胞水平低于350个/μL;病情进入艾滋病期的HIV感染者1个月内开始ART治疗的患者比例明显高于无症状期感染者(χ2=6914,P<0.05),而HIV感染确证4个月后才开始ART治疗的无症状期感染者比例明显高于病情进入艾滋病期的感染者(χ2=75.56,P<0.05);来自区县的患者中艾滋病期患者比例明显高于主城地区(χ2=28.50,P<0.05),前者出现艾滋病的发病风险为后者的1.69倍(95%CI:1.47~1.95);接受ART治疗者以20~40岁的HIV感染者为主(58.6%),男男同性性行者在总病例中占有较高比例(47.6%),且病情进入艾滋病期者比例最低(39.6%),有男男同性性行为的HIV感染者进入艾滋病期的比例低于经其他途径获得感染者。结论      重庆市HIV感染者在诊断为HIV感染时,大部分已进入艾滋病期;无症状期HIV感染者存在拖延ART治疗开始时间的倾向;来自区县的HIV感染者艾滋病发病风险高于主城区感染者;年龄偏大和非经男男性行为途径而获得HIV感染的患者病情进展到艾滋病期的风险高于年轻和男男同性恋者。

Abstract:

Objective     T o study clinical features and risk factors of disease progression in human immunodeficiency virus (HIV)infected patients from Chongqing region. Methods      A total of 1 978 HIV-infected patients receiving antiretroviral therapy (ART) in Chongqing Public Health Medical Center between 2013 and 2015 were retrospectively analyzed. The data were collected according to patients’ basic information, demographic factors, and clinical examination combined with disease complications. Results      Of the 1 978 cases, 54.9% of them had acquired immunodeficiency syndrome (AIDS) before initiation of ART, and over 90% of them had a lower level of CD4+ cells (less than 350 cells/μL). The percentage of HIVinfected patients who received ART within 1 month of AIDS diagnosis was significantly higher than those without symptoms(Chi square=69.14,P<0.05). But, the percentage of asymptomatic HIV-infected patients receiving ART after 4 months of diagnosis was dramatically higher than those with AIDS (Chi square=75.56,P<0.05). The patients from suburbs were more likely to have AIDS compared to those living in the city(Chi square=28.50,P<0.05), showing 1.69-fold higher risk of AIDS incidence(95%CI:1.47~1.95). The majority of patients (58.6%) receiving ART was aged from 20 to 40 years. Male homosexuality accounted for a higher proportion (47.6%) of the study with the lowest incidence of AIDS (39.6%). In addition, the onset of AIDS was lower in younger patients than older ones. The HIV-infected patients transmitted by male homosexuality were less progressed to AIDS compared to those infected by heterogeneous sex, blood transfusion, injection drug use and unidentified transmission routes. Conclusion      Most of HIV-infected patients are diagnosed with AIDS before the initiation of ART. Asymptomatic HIV-infected patients tend to have a delay to start the ART. Patients living in suburbs are more likely to have AIDS. Also, patients who are older and infected by HIV but not through homosexuality were more likely to progress to AIDS.

相似文献/References:

[1]陈敏.2005-2009年重庆市沙坪坝区性病疫情分析[J].第三军医大学学报,2010,32(18):2010.
 Chen Min.Epidemic situation of sexually transmitted diseases in Shapingba district, Chongqing from 2005 to 2009[J].J Third Mil Med Univ,2010,32(19):2010.
[2]曹齐,陈思源.AIDS合并隐球菌相关性免疫重建炎性综合征1例[J].第三军医大学学报,2013,35(22):2476.
[3]程良金,叶庆佾,刘和平,等.重庆地区首例艾滋病报告[J].第三军医大学学报,1996,18(06):0.[doi:10.16016/j.1000-5404.1996.06.011 ]

更新日期/Last Update: 2016-10-11