[1]廖君,王晓果,孔佩艳,等.血清uPA蛋白水平与急性髓系白血病的预后有关[J].第三军医大学学报,2016,38(12):1371-1373.
 Liao Jun,Wang Xiaoguo,Kong Peiyan,et al.Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia[J].J Third Mil Med Univ,2016,38(12):1371-1373.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
38卷
期数:
2016年第12期
页码:
1371-1373
栏目:
专题报道
出版日期:
2016-06-30

文章信息/Info

Title:
Serum urokinase type plasminogen activator is related to prognosis of acute myeloid leukemia
作者:
廖君王晓果孔佩艳张曦易海朱丽丹刘耀张诚高蕾
第三军医大学新桥医院全军血液病中心
Author(s):
Liao Jun Wang Xiaoguo Kong Peiyan Zhang Xi Yi Hai Zhu Lidan Liu Yao Zhang Cheng Gao Lei

Center of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China

关键词:
尿激酶纤溶酶原激活物急性髓系白血病预后
Keywords:
urokinase type plasminogen activator acute myeloid leukemia prognosis
分类号:
R341; R730.43; R733.71
文献标志码:
A
摘要:

目的      探索尿激酶纤溶酶原激活物(urokinase type plasminogen activator, uPA)在急性髓系白血病(acute myeloid leukemia,AML)患者血清中的表达及与预后的关系。      方法      采用酶联免疫吸附的方法检测45例初始治疗前AML患者及10例健康体检者血清uPA蛋白表达水平,分别对其中25例预后不良组、10例预后良好组、10例预后中等组患者及10例正常对照组血清uPA蛋白表达水平进行统计学分析比较。      结果      初始治疗前AML患者血清uPA蛋白表达水平明显高于正常对照组,差异具有统计学意义(P<0.05);预后不良组AML患者血清uPA蛋白表达水平明显高于预后良好组及预后中等组,差异具有统计学意义(P<0.05)。      结论      uPA蛋白的表达与AML患者危险分层密切相关,监测AML患者血清uPA蛋白表达水平有助于早期判断AML患者的预后。

Abstract:

Objective      To determine the level of urokinase type plasminogen activator(uPA) in the serum of patients with acute myeloid leukemia(AML) and investigate its correlation with the prognosis of the disease.       Methods      Serum uPA protein level was determined by enzyme linked immunosorbent assay (ELISA) in 45 untreated AML patients (including 25 poor prognosis patients, 10 favorable prognosis patients and 10 moderate prognosis patients) and 10 healthy subjects, and the results were compared and analyzed among the groups.       Results      The serum level of uPA protein was significantly higher in AML patients than healthy subjects(P<0.05).A significant increase of serum uPA levels was found in poor prognosis AML patients compared to other control groups(P<0.05).       Conclusion      The serum level of uPA has a close relationship with the risk stratification of AML. Monitoring the serum uPA level is helpful for early prognostic prediction in newly diagnosed AML patients.

参考文献/References:

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更新日期/Last Update: 2016-06-07