[1]陶林,樊丽琳,刘海燕,等.食管上段异位胃黏膜的组织学特点及临床意义[J].第三军医大学学报,2013,35(09):905-909.
 Tao Lin,Fan Lilin,Liu Haiyan,et al.Histological features and clinical significance of heterotopic gastric mucosa in upper esophagus[J].J Third Mil Med Univ,2013,35(09):905-909.
点击复制

食管上段异位胃黏膜的组织学特点及临床意义(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第09期
页码:
905-909
栏目:
论著
出版日期:
2013-05-15

文章信息/Info

Title:
Histological features and clinical significance of heterotopic gastric mucosa in upper esophagus
作者:
陶林樊丽琳刘海燕沈小春闫庆军兰春慧王军李宁傅鑫赵敦勇刘卉刑寒阳张艳梅李丽杨均肖潇樊玲潘大维颜綦先敖兴李平牟江洪 肖华亮 陈东风
第三军医大学大坪医院野战外科研究所:消化内科,病理科
Author(s):
Tao Lin Fan Lilin Liu Haiyan Shen Xiaochun Yan Qingjun Lan Chunhui Wang Jun Li Ning Fu Xin Zhao Dunyong Liu Hui Xin Hanyang Zhang Yanmei Li Li Yang Jun Xiao Xiao Fan Lin Pan Dawei Yan Qixian Ao Xing Li Ping Mou Jianghong Xiao Hualiang Chen Dongfeng
Department of Gastroenterology, Department of Pathology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China
关键词:
HGMUENBI共聚焦激光显微内镜组织学
Keywords:
heterotopic gastric mucosa in upper esophagus narrow band imaging confocal laser endomicroscopy histology
分类号:
R322.43; R322.44; R571
文献标志码:
A
摘要:
目的   观察食管上段异位胃黏膜(heterotopic gastric mucosa in upper esophagus,HGMUE)的组织学特点以及内镜下表现,研究患者各相关临床症状与HGMUE泌酸功能之间的联系。   方法    分析40例普通内镜下诊断为HGMUE的患者的临床表现、NBI内镜以及共聚焦激光显微内镜(confocal laser endomicroscopy,CLE)特点,采用透射电镜、HE、免疫组化观察其病理学特征。   结果    40例患者中,平坦型38例(95%),隆起型2例(5%),病变形态有椭圆形18例(45%)、圆形9例(22.5%)、不规则岛状7例(17.5%)、条索状6例(15%);NBI内镜下,可清楚区分病变区域与周围正常食管黏膜,小凹形态以管状(92.5%)为主,未发现表面微血管扩张变异;CLE扫描腺管开口呈胃底型27例,非胃底型13例,结合HE病理诊断,符合率为92.5%,有不同程度的荧光素钠渗出;透射电镜显示细胞超微结构与正常胃黏膜无明显差异,HE染色胃底型腺体28例(70%),非胃底型腺体12例(30%);免疫组化结果显示,胃底型腺体中质子泵、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ表达均为阳性;相关临床症状中除胸骨后疼痛与壁细胞有关外(P<0.05),其余症状壁细胞均无统计学差异(P>0.05)。    结论    HGMUE患者病理分型以胃底型为主,此种异位胃黏膜可能有分泌胃酸及胃蛋白酶的能力,与患者胸骨后疼痛的症状相关;NBI内镜及CLE对于HGMUE的诊断比普通内镜可能具有更好的分辨效果及价值。
Abstract:
Objective    To investigate the histological characteristics and endoscopic features of heterotopic gastric mucosa in upper esophagus (HGMUE), and explore the correlation between the clinical symptoms and acid secretion of the patches.    Methods    The clinical manifestations, narrow band imaging (NBI) endoscopy and confocal laser endomicroscopy (CLE) characteristics of 40 cases of HGMUE patients diagnosed by common endoscopy in our department from March to November 2011 were retrospectively collected and analyzed. Transmission electron microscopy, HE staining, immunohistochemical assay was used to observe pathological features.    Results    In 40 patients, flat type was in 38 cases(95%), and 2 cases were with elevated type(5%). Lesion morphology with oval shape was found in 18 cases (45%), 9 cases (22.5%) with round, irregular island in 7 cases (17.5%), and cords in 6 cases (15%). NBI endoscopy clearly distinguished the lesion and surrounding normal esophageal mucosa. Pits were mainly tubular (92.5%). No surface microvascular dilatation was observed. CLE scanning showed fundic type in 27 cases, with a coincidence rate of 92.5% when combined with HE pathologic diagnosis. The patches had different degrees of sodium fluorescence exudation. Transmission electron microscopy showed no significant difference between ectopic gastric mucosa and normal gastric mucosa in cell ultra-structure. HE staining showed fundic type gastric mucosa in 28 cases (70%), and non-fundic type in 12 cases (30%). Immunohistochemical assay displayed that proton pump, pepsinogen Ⅰ, and pepsinogen Ⅱ were all positively expressed. In the symptoms associated with HEMUE, retrosternal pain related to the presence of parietal cells (P<0.05), but others did not (P>0.05).    Conclusion    Most of the topic gastric mucosa in HGMUE are fundic type gastric mucosa, which secretes gastric acid and pepsin, and directly related to the symptoms of retrosternal pain. NBI endoscopy and CLE have better resolution and value in the diagnosis of HGMUE than ordinary endoscopy.

参考文献/References:

陶林, 樊丽琳, 刘海燕, 等. 食管上段异位胃黏膜的组织学特点及临床意义[J].第三军医大学学报,2013,35(9):905-909.

更新日期/Last Update: 2013-05-03