[1]高伊星,李鹏,蒋春华,等.久居高原青年官兵脑功能的变化特征及其相关因素研究[J].第三军医大学学报,2013,35(10):1001-1004.
 Gao Yixing,Li Peng,Jiang Chunhua,et al.Characteristics and related factors of brain function in long staying soldiers at high altitude[J].J Third Mil Med Univ,2013,35(10):1001-1004.
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久居高原青年官兵脑功能的变化特征及其相关因素研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第10期
页码:
1001-1004
栏目:
论著
出版日期:
2013-05-30

文章信息/Info

Title:
Characteristics and related factors of brain function in long staying soldiers at high altitude
作者:
高伊星李鹏蒋春华陈郁刘春高钰琪阮怀珍
第三军医大学:基础医学部神经生物学教研室, 重庆市神经生物学重点实验室,高原军事医学系高原军队卫生学教研室,高原军事医学系病理生理学与高原生理学教研室,全军高原医学重点实验室,高原医学教育部重点实验室
Author(s):
Gao Yixing Li Peng Jiang Chunhua Chen Yu Liu Chun Gao Yuqi Ruan Huaizhen
Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, College of Basic Medical Sciences,Department of High Altitude Military Hygiene,Department of Pathophysiology and High Altitude Physiology, Key Laboratory of High Altitude Medicine of Ministry of Education, Key Laboratory of High Altitude Medicine of PLA, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038, China
关键词:
高海拔缺氧神经行为学表现认知睡眠
Keywords:
altitude hypoxia brain neurobehavioral manifestations cognition sleep
分类号:
R338.2;R338.6;R339.54
文献标志码:
A
摘要:
目的      研究长期移居高原对脑功能的影响及其与移居高原时间、睡眠质量、脑组织氧供情况等因素的相关性。      方法      对平原青年男性官兵65例、移居4 500 m高原地区1~15年的青年男性官兵64例进行神经行为核心测试组合测试、瑞文标准推理测试和匹兹堡睡眠质量指数问卷调查,并进行血氧饱和度和左、右脑组织氧合指数的检测。      结果      久居高原者左、右脑组织氧合指数显著降低(P<0.01),并与血氧饱和度呈显著正相关(r=0.364,P<0.01)。长期高原移居者对颜色尤其是蓝色反应延迟(P<0.05),颜色辨别能力下降(P<0.01),短时视觉记忆能力降低(P<0.01),运动稳定性降低(P<0.05)等。久居高原者焦虑、抑郁、敌意、困惑等不良情绪状态增强(P<0.05),睡眠质量下降(P<0.01)。除匹兹堡睡眠质量指数与脑组织氧合指数有相关性(r=-0.287,P<0.05)外,久居高原者其他脑功能的变化与脑组织氧供状况无显著相关性(P>0.05)。认知功能中平均颜色反应时、本顿视觉保留测试得分两项指标与移居高原时间呈显著相关性(r=0.268,r=-0.277,P<0.05)。      结论      长期移居高原对视觉功能、运动稳定性、情绪和睡眠有显著负面影响,脑氧合指数和移居高原时间是脑功能降低的影响因素。
Abstract:
Objective      To investigate the features and related factors of brain function in long staying soldiers at high altitude.       Methods      Sixty-four male soldiers living at the plain and 65 soldiers living at 4 500 m altitude for 1-15 years were enrolled in this study. The neurobehavioral core tests battery (NCTB) and Raven’s standard progressive matrices (RSPM) test were adopted to evaluate cognitive capacity. The sleep quality was investigated using Pittsburgh sleep quality index (PSQI). Meanwhile, the resting oxyhemoglobin saturation (SaO2) and the brain tissue oxygenation index (TOI) were also measured.       Results      The brain TOI of the soldiers living at 4 500 m altitude decreased significantly (P<0.01) and was positively correlated with SaO2(r=0.364). They were more fallible on color discrimination (P<0.01), were slower on reaction to blue color stimulus (P<0.05), and exhibited significantly worse emotions (P<0.05) and performance on visual retention (P<0.01) and motor stability (P<0.05). Except for a negative correlation between PSQI and brain TOI (r=-0.287), no other decreasing brain function was associated with reduced brain oxygen supply. The color reaction time and visual retention were associated with residence time at high altitude (r=0.268, r=-0.277).       Conclusion      Chronic hypoxic exposure at high altitude has a profound effect on the negative effect on the visual function, motion stability, emotion and sleep quality. Brain TOI and residence time are influencing factors of impaired brain function at high altitude.

参考文献/References:

高伊星, 李鹏, 蒋春华, 等. 久居高原青年官兵脑功能的变化特征及其相关因素研究[J].第三军医大学学报,2013,35(10):1001-1004.

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更新日期/Last Update: 2013-05-20