[1]刘晓丽,马礼鸿,王全义,等.XIAP、c-jun在肺癌组织中的表达及其意义[J].第三军医大学学报,2012,34(23):2408-2410.
 Liu Xiaoli,Ma Lihong,Wang Quanyi,et al.Expression and clinical significance of XIAP and c-jun in human lung cancer tissues[J].J Third Mil Med Univ,2012,34(23):2408-2410.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第23期
页码:
2408-2410
栏目:
论著
出版日期:
2012-12-15

文章信息/Info

Title:
Expression and clinical significance of XIAP and c-jun in human lung cancer tissues
作者:
刘晓丽马礼鸿王全义王凯
遵义医学院附属医院病理科;遵义市第一人民医院外科;济宁医学院附属医院病理科
Author(s):
Liu Xiaoli Ma Lihong Wang Quanyi Wang Kai
Department of Pathology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou Province, 563003; Department of Surgery, First People’s Hospital of Zunyi City, Zunyi, Guizhou Province, 563003; Department of Pathology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, 272029, China
关键词:
XIAPc-jun肺癌组织芯片预后
Keywords:
XIAP c-jun lung cancer tissue microarray prognosis
分类号:
R730.23; R734.2
文献标志码:
A
摘要:
目的      探讨XIAP及c-jun在原发性肺癌组织中的表达水平及其临床意义。      方法       选用组织芯片应用免疫组化S-P法检测XIAP、c-jun蛋白在正常肺组织、肺良性病变、肺癌旁组织和原发性肺癌组织中的表达。      结果       XIAP、c-jun 在肺癌组织中的阳性表达率均明显升高,恶性组显著高于正常组、良性组和癌旁组(P<0.05),XIAP、c-jun在肺癌临床晚期(Ⅲ期和Ⅳ期)组的阳性表达水平(MOD值)均明显高于临床早期(Ⅰ期和Ⅱ期)组(P<0.05),XIAP、c-jun的阳性表达水平在有淋巴结转移组均高于无淋巴结转移组(P<0.05),XIAP与c-jun在肺癌组织中阳性表达呈正相关(r=0.232,P<0.05),术后生存期小于1年患者的XIAP、c-jun阳性表达率均明显高于生存期超过1年患者(P<0.05)。XIAP、c-jun的MOD值与患者性别、年龄、肿块直径和组织学类型均无关(P>0.05)。      结论       XIAP、c-jun蛋白阳性水平的高表达提示患者预后较差,联合检测XIAP、c-jun蛋白阳性表达水平可作为临床诊断及患者预后预测的参考指标。
Abstract:
Objective        To investigate the expression levels and clinical significance of X-linked inhibitor of apoptosis protein (XIAP) and c-jun in primary lung cancer tissues.       Methods       Immunohistochemical SP method was used to detect the expression levels of XIAP and c-jun in normal lung tissues, lung benign lesions, adjacent tissues of lung cancer and primary lung cancer tissues.       Results       The positive expression rates of XIAP and c-jun in the primary lung cancer tissues were significantly higher than those in the normal lung tissues, lung benign lesions and adjacent tissues of lung cancer (P<0.05). The positive expression levels (MOD value) of XIAP and c-jun in advanced lung cancer tissues (Stage Ⅲ and Ⅳ) were significantly higher than those in the early-stage lung cancer tissues (Stage Ⅰ and Ⅱ) (P<0.05). The  positive expression levels of XIAP and c-jun in the lung cancer tissues with lymph node metastasis were significantly higher than those in the lung cancer tissues without lymph node metastasis (P<0.05). The positive expression levels (MOD value) of XIAP and c-jun were positively correlated in the lung cancer tissues (r=0.232,P<0.05). The positive expression levels of XIAP and c-jun in the patients with postoperative survival time less than 1 year were significantly higher than those in the patients with postoperative survival time more than 1 year (P<0.05). The positive expression levels (MOD value) of XIAP and c-jun were not correlated with patients’ age, sex, tumor diameter or histopathological type (P<0.05).       Conclusion       High expression of XIAP and c-jun indicates poor prognosis of patients with lung cancer. XIAP and c-jun expression levels can be used as reference indices for clinical diagnosis and prognosis prediction in patients with lung cancer.

参考文献/References:

刘晓丽, 马礼鸿, 王全义, 等. XIAP、c-jun在肺癌组织中的表达及其意义[J]. 第三军医大学学报,2012,34(23):2408-2410.

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更新日期/Last Update: 2012-12-04