[1]雷莉,张艳,胡华,等.早年慢性应激对青春期大鼠攻击行为及下丘脑腹内侧核和前额皮质脑源性神经营养因子表达的影响[J].陆军军医大学学报(原第三军医大学学报),2013,35(03):233-236.
 Lei Li,Zhang Yan,Hu Hua,et al.Effect of early chronic life stress on aggressive behavior and expression of brain-derived neurotrophic factor in hypothalamus and prefrontal cortex in puberty rats[J].J Amry Med Univ (J Third Mil Med Univ),2013,35(03):233-236.
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早年慢性应激对青春期大鼠攻击行为及下丘脑腹内侧核和前额皮质脑源性神经营养因子表达的影响(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第03期
页码:
233-236
栏目:
论著
出版日期:
2013-02-15

文章信息/Info

Title:
Effect of early chronic life stress on aggressive behavior and expression of brain-derived neurotrophic factor in hypothalamus and prefrontal cortex in puberty rats
作者:
雷莉张艳 胡华秦光成陈力学屈远
重庆医科大学附属第一医院:心理卫生中心,神经病学实验室
Author(s):
Lei Li Zhang Yan Hu Hua Qin Guangcheng Chen Lixue Qu Yuan
Department of Psychiatry, Laboratory of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
早年慢性应激攻击行为BDNF
Keywords:
early chronic life stress aggressive behavior BDNF
分类号:
R338.6; R339.32; R363.27
文献标志码:
A
摘要:
目的      探讨早年慢性应激对青春期大鼠攻击行为以及大脑下丘脑腹内侧核和前额皮质脑源性神经营养因子(brain-derived neurotrophic factor, BDNF)表达的影响。      方法       将20只SD大鼠分为实验组和对照组。实验组大鼠出生后21 d开始进行社会孤养、日夜颠倒、社会刺激性实验和居住-入侵实验等多种早年应激3周。免疫组化检测下丘脑腹内侧核和前额皮质BDNF的表达。      结果        实验组在居住-入侵实验和中性环境实验中攻击/威胁比[分别为(12.45±9.27)、(10.84±4.93)]和攻击持续时间[分别为(333.10±76.34)、(322.20±57.67)s]均显著高于对照组(P<0.01),而攻击潜伏期[分别为(15.20±11.07)、(18.30±11.32)s]显著低于对照组(P<0.01),并且表现出暴力攻击行为。免疫组化检测结果显示, 实验组下丘脑腹内侧核BDNF表达(0.20±0.09)高于对照组(P<0.05),前额皮质BDNF(0.19±0.08)表达水平低于对照组(P<0.05)。      结论      早年慢性应激引起青春期大鼠暴力攻击行为以及下丘脑腹内侧核和前额皮质BDNF表达改变,提示青春期暴力攻击行为可能与早年慢性应激所致BDNF表达改变有关。
Abstract:
Objective      To explore the effect of early chronic life stress on aggressive behavior and expression of brain-derived neurotrophic factor (BDNF) of ventromedial hypothalamus nucleus and prefrontal cortex in puberty rats.       Methods      Twenty rats were randomly divided into 2 groups: an experimental group and a control group. The rats of the experimental group were given a series of stress including social isolation, reversal of day and night, social stimulation and resident-intruder confrontation at the 21st day after birth for 3 weeks. The expression of BDNF in ventromedial hypothalamus nucleus and prefrontal cortex was determined by immunohistochemistry.       Results       The  attack/threat (A/T) ratio (12.45±9.27, 10.84±4.93) and duration of attack manifestations (DAM)(333.10±76.34, 322.20±57.67) in resident-intruder test and neutral arena test increased significantly in the experimental group as compared with the control group (P<0.01), while the latency of the first attack (15.20±11.07, 18.30±11.32 s) decreased significantly (P<0.01). Moreover, the rats of experimental group exhibited violence behavior. Compared with the control group, the expression of BDNF elevated significantly in ventromedial hypothalamus nucleus (0.20±0.09, P<0.05), and decreased significantly in prefrontal cortex (0.19±0.08, P<0.05) in the experimental group.       Conclusion       The violence behavior in puberty rats induced by early chronic life stress may be associated with the altered expression of BDNF in ventromedial hypothalamus nucleus and prefrontal cortex.

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 Ma Zhongrui,Meng Huaqing,Hu Hua,et al.Childhood abuse and aggressive behavior in violent adolescent criminals with adolescence- vs children-onset antisocial behavior[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(03):2511.
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[3]顾璇,姚荣英.交往焦虑与中学生攻击行为的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2011,33(19):2091.

更新日期/Last Update: 2013-01-29