[1]刘小军,张雪琳,李莎莎,等.172例肺腺癌脑转移影响因素的临床分析[J].第三军医大学学报,2013,35(01):73-76.
 Liu Xiaojun,Zhang Xuelin,Li Shasha,et al.Clinical analysis of influencing factors for 172 lung adenocarcinoma patients with brain metastasis[J].J Third Mil Med Univ,2013,35(01):73-76.
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172例肺腺癌脑转移影响因素的临床分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第01期
页码:
73-76
栏目:
论著
出版日期:
2013-01-15

文章信息/Info

Title:
Clinical analysis of influencing factors for 172 lung adenocarcinoma patients with  brain metastasis
作者:
刘小军张雪琳李莎莎胡义德
第三军医大学新桥医院全军肿瘤诊治研究所
Author(s):
Liu Xiaojun Zhang Xuelin Li Shasha Hu Yide
Institute of Oncology Diagnosis and Treatment, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
肺腺癌脑转移影响因素临床分析
Keywords:
lung adenocarcinoma brain metastasis influencing factors clinical analysis
分类号:
R181.32; R73-37; R734.2
文献标志码:
A
摘要:
目的      探讨肺腺癌脑转移临床影响因素,为肺腺癌临床诊治提供参考。      方法      回顾性分析本院2005-2010年172例肺腺癌脑转移患者的临床资料。通过生存分析Kaplan-Meier法计算累计脑转移率并进行Log-Rank检验比较,全组患者通过比例风险模型(Cox模型)进行多因素分析。      结果      患者从确诊到出现脑转移中位时间为13个月,1年累计脑转移发生率47.1%,2年累计脑转移发生率72.7%。单因素分析显示患者的行为状态ECOG评分、原发肿瘤数目、T分期、N分期、M分期、TNM分期、治疗情况和近期疗效等对脑转移有影响(P<0.001)。多因素分析显示N分期(P=0.001)、M分期(P=0.000)、TNM分期(P=0.042)、近期疗效(P<0.001)对脑转移影响存在显著差异。      结论      N分期、M分期、TNM分期、近期疗效可能是影响肺腺癌脑转移的重要因素。
Abstract:
Objective      To investigate the clinical influencing factors for lung adenocarcinoma patients with brain metastasis (BM), and to provide references for clinical diagnosis and treatment of lung adenocarcinoma.       Methods      Clinical data of 172 lung adenocarcinoma patients with brain metastasis from 2005 to 2010 were retrospectively analyzed. The cumulative incidence of BM was estimated using Kaplan-Meier method, and the differences among groups were analyzed using Log-rank test. Multivariate Cox regression analysis was applied to assess the influencing factors of BM.       Results      The median time from lung adenocarcinoma diagnosed to brain metastasis onset in all the patients was 13 months. One- and 2-year incidences of BM were 47.1% and 72.7%, respectively. The results of univariate analysis showed that the probability of brain metastasis was positively correlated with patients’ ECOG status (P<0.001), number of primary tumor (P<0.001), T-stage (P<0.001), N-stage (P<0.001), M-stage (P<0.001), TNM-stage (P<0.001), treatment modalities (P<0.001) and short-term curative effect (P<0.001). The results of multivariate analysis showed that N-stage (P=0.001), M-stage (P=0.000), TNM-stage (P=0.042) and short-term curative effect (P<0.001) were independent influencing factors for the lung adenocarcinoma patients with brain metastasis.       Conclusion      The incidence of brain metastasis from primary lung adenocarcinoma is correlated with N-stage, M-stage, TNM-stage and short-term curative effect.

参考文献/References:

刘小军,张雪琳,李莎莎,等. 172例肺腺癌脑转移影响因素的临床分析[J].第三军医大学学报,2013,35(1):73-76.

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更新日期/Last Update: 2012-12-31