[1]张笑春,屈清华,季冰,等.伴发隐性脊柱裂的女性不孕症发病率及其病因分析[J].第三军医大学学报,2013,35(04):332-334.
 Zhang Xiaochun,Qu Qinghua,Ji Bin,et al.Prevalence and etiological factors of female infertility with spina bifida occulta[J].J Third Mil Med Univ,2013,35(04):332-334.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
35卷
期数:
2013年第04期
页码:
332-334
栏目:
论著
出版日期:
2013-02-28

文章信息/Info

Title:
Prevalence and etiological factors of female infertility with spina bifida occulta
作者:
张笑春屈清华季冰黎海涛陈伟 吴宗乾王健
第三军医大学西南医院:放射科,妇产科,生殖医学中心
Author(s):
Zhang Xiaochun Qu Qinghua Ji Bin Li Haitao Chen Wei Wu Zongqian Wang Jian
Department of Radiology, Center of Reproductive Medicine, Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
关键词:
隐性脊柱裂不孕症发病率女性病因
Keywords:
neural tube defects spina bifida occulta infertility prevalence female etiological factor
分类号:
R682.3;R711.6
文献标志码:
A
摘要:
目的      探讨伴发腰骶椎隐性脊柱裂女性不孕症的发病率及其主要病因分布。      方法      收集本院2011年1月至2012年1月1 172例经临床证实女性不孕症患者(不孕组),依据是否伴发隐性脊柱裂分为隐性脊柱裂不孕(spina bifida occulta ,SBO组, 621例)组和非隐性脊柱裂不孕(NSBO组,551例)组,对比分析两组原、继发不孕症患者的发病率和病因分布特点。另外选取非女性不孕症患者1 780例作为对照组计算就医女性人群中SBO的发生率。      结果      ①SBO发病率不孕组组为52.99%,对照组为9.44%(P<0.05)。SBO组原发不孕(339例,28.93%)多于继发不孕(282例,24.06%)(P<0.05),NSBO组继发不孕(529例,45.14%)明显多于原发不孕(22例,1.88%)(P<0.01)。②SBO组不孕病因多、复杂且多交叉,原发不孕以卵巢因素、免疫因素和内分泌因素为主,继发不孕以感染、免疫因素和内分泌因素为主;NSBO组不孕病因主要以手术及其并发感染为主(P<0.05)。      结论      女性隐性脊柱裂患者不孕症发病率比非隐性脊柱裂女性相对高。
Abstract:
Objective      To investigate the prevalence and etiological factors of female infertility with spina bifida occulta (SBO).       Methods      A total of 1 172 infertile women (infertility group) in our hospital from January 2011 to January 2012 were enrolled in this study. They were divided into SBO subgroup (n=621) and non-SOB subgroup (NSBO, n=551) according to with or without SBO confirmed by X-ray film. The characteristics of prevalence and etiological factors between primary and secondary infertile women were evaluated and compared in 2 groups. Another 1 780 female patients without infertility and prevalence of SBO served as control.       Results      Prevalence of SBO was 52.99% in the infertility group, but only 9.44% in the control group. Prevalence of primary infertility (339,28.93%)was larger than secondary infertility(282,24.06%)(P<0.05)in SBO subgroup. Prevalence of primary infertility (22, 1.88%)was lesser than secondary infertility(529, 45.14%)(P<0.01)in NSBO subgroup. There were multiple complicated etiological factors for SBO. Primary infertility was due to disorders of ovulation, immunity factors and endocrine factors. Secondary infertility was due to tubal and uterus infection, immunity factors and endocrine factors. Surgery and infection induced by surgery were major etiological factors for female infertility in NSBO group(P<0.05).       Conclusion      Female infertility with SBO has higher prevalence than those without.

参考文献/References:

张笑春, 屈清华, 季冰, 等. 伴发隐性脊柱裂的女性不孕症发病率及其病因分析[J].第三军医大学学报,2013,35(4):332-334.

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更新日期/Last Update: 2013-02-25