[1]陈剑玲,商黔惠,赵鸿彦,等.原发性高血压患者血尿酸水平与冠状动脉病变程度的相关性分析[J].第三军医大学学报,2012,34(17):1790-1792.
 Chen Jianling,Shang Qianhui,Zhao Hongyan,et al.Correlation between serum uric acid level and severity of coronary artery lesions in patients with essential hypertension[J].J Third Mil Med Univ,2012,34(17):1790-1792.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第17期
页码:
1790-1792
栏目:
论著
出版日期:
2012-09-15

文章信息/Info

Title:
Correlation between serum uric acid level and severity of coronary artery lesions in patients with essential hypertension
作者:
陈剑玲商黔惠赵鸿彦邓熠
遵义医学院:临床医学研究所,附属医院心内科
Author(s):
Chen Jianling Shang Qianhui Zhao Hongyan Deng Yi
Institute of Clinical Medicine, Department of Cardiology, Affiliated Hospital, Zunyi Medical College, Zunyi, Guizhou, 563003, China
关键词:
原发性高血压冠状动脉疾病血尿酸
Keywords:
essential hypertension serum uric acid coronary artery lesion
分类号:
R446.11; R543.3; R544.1
文献标志码:
A
摘要:
目的      评估原发性高血压患者血尿酸(serum uric acid,SUA)水平与冠状动脉病变程度的相关性。      方法        收集我院2010年1月至2011年12月行冠脉造影的原发性高血压患者538例,包括男性433例,女性105例,年龄31~84(62.9±9.75)岁,其中明确冠心病362例,排除冠心病176例,根据SUA水平四分位数将原发性高血压患者分为第1四分位数组、第2四分位数组、第3四分位数组、第4四分位数组,分析各组患者SUA水平与冠状动脉病变程度的相关性,冠状动脉病变程度由冠状动脉病变支数及病变Gensini积分表示。      结果       SUA是高血压患者合并冠心病的独立危险因素(OR=1.003,95%CI 1.001~1.005,P<0.05),原发性高血压合并冠心病患者SUA水平与冠状动脉病变支数及冠状动脉病变Gensini积分有显著正关联(r=0.128,P<0.01;r=0.163,P<0.01)。      结论        原发性高血压患者SUA水平升高与冠状动脉病变程度密切相关。
Abstract:
Objective        To investigate the correlation between serum uric acid (SUA) level and the severity of coronary artery lesions in patients with essential hypertension.       Methods        A total of 538 essential hypertension patients who had undergone coronary angiography from Jan. 2010 to Dec. 2011 in our hospital were enrolled, including 362 patients with coronary heart disease (CHD) and 176 patients without CHD. According to the level of SUA, the essential hypertension patients were divided into the first quartile groups, the second quartile groups, the third quartile groups and the fourth quartile groups. The correlation between the level of SUA and the severity of coronary artery lesions was analyzed. The severity of coronary artery lesions was expressed by the number of stenosed vessels and coronary artery disease Gensini cumulative index.       Results        The level of SUA was an independent risk factor for essential hypertension patients complicated with CHD (OR=1.003, 95%CI 1.001 to 1.005, P<0.05), and was positively correlated with the number of stenosed vessels and the coronary artery disease Gensini cumulative index in the essential hypertension patients complicated with CHD (r=0.128, P<0.01; r=0.163, P<0.01).       Conclusion        Elevated level of SUA is closely correlated with the occurrence of CHD and the severity of coronary artery lesions in patients with essential hypertension.

参考文献/References:

陈剑玲, 商黔惠, 赵鸿彦, 等. 原发性高血压患者血尿酸水平与冠状动脉病变程度的相关性分析[J].第三军医大学学报,2012,34(17):1790-1792.

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更新日期/Last Update: 2012-08-31