[1]李佳丽,刘耀,曾东风,等.硼替佐米联合地塞米松和沙利度胺治疗多发性骨髓瘤的临床研究[J].第三军医大学学报,2012,34(24):2515-2517.
 Li Jiali,Liu Yao,Zeng Dongfeng,et al.Bortezomib combined with dexamethasone and thalidomide in treatment of multiple myeloma: report of 58 cases[J].J Third Mil Med Univ,2012,34(24):2515-2517.
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硼替佐米联合地塞米松和沙利度胺治疗多发性骨髓瘤的临床研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第24期
页码:
2515-2517
栏目:
论著
出版日期:
2012-12-30

文章信息/Info

Title:
Bortezomib combined with dexamethasone and thalidomide in treatment of multiple myeloma: report of 58 cases
作者:
李佳丽刘耀曾东风李杰平陈幸华张曦彭贤贵孔佩艳
第三军医大学新桥医院血液科,全军血液病中心
Author(s):
Li Jiali Liu Yao Zeng Dongfeng Li Jieping Chen Xinghua Zhang Xi Peng Xiangui Kong Peiyan
Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing,400037, China
关键词:
多发性骨髓瘤硼替佐米疗效不良反应
Keywords:
multiple myeloma bortezomib efficacy adverse effects
分类号:
R733.3;R977.11;R979.1
文献标志码:
A
摘要:
目的      观察硼替佐米联合地塞米松和沙利度胺(VTD)方案对多发性骨髓瘤(multiple myeloma,MM)患者的临床疗效。      方法      收集2008年4月至2012年2月于本院接受VTD方案治疗的58例MM患者临床资料,并以同期30例传统长春新碱+蒽环类+地塞米松+沙利度胺(VADT)方案化疗的MM患者作为对照,分析病情转归及不良反应。患者均完成2个及以上疗程治疗。      结果      随访6个月至2年的MM患者:①VTD用于初治和复发和(或)难治MM患者的总有效率显著高于VADT组(63.8% vs 40.0%,P<0.05)。VTD方案中初治患者治疗总有效率显著高于复发和(或)难治患者(77.8% vs 40.9%,P<0.05);VTD组治疗初治MM的有效率也明显高于VADT组(36.0%),差异有统计学意义(P<0.05)。VTD治疗复发和(或)难治MM的有效率与VADT组(60.0%)无差异(P>0.05)。VTD组内轻链型、非轻链型MM患者疗效无显著统计学差异(P>0.05)。②VTD治疗不良反应主要有消化道症状、感染、周围神经病变及血小板减少。      结论      硼替佐米联合地塞米松和沙利度胺治疗MM缓解率高,副作用少且一般较轻微,可首选用于治疗初治及复发和(或)难治MM患者。
Abstract:
Objective      To observe the efficiency of combination of bortezomib plus dexamethasone and thalidomide (VTD) in treatment of multiple myeloma (MM).       Methods      From April 2008 and February 2012, fifty-eight MM patients underwent VTD treatment in Xinqiao Hospital. A contemporary cohort of 30 MM patients receiving VADT(vincristine+anthracycline+dexamethasone+thalidomide) chemotherapy was set as the control group. The prognosis of disease and adverse effects were analyzed. All subjects were taken chemotherapy in two or more cycles of treatment. All patients were followed up for 6 months to 2 years.       Results      The total effective rate of the VTD group was 63.8%, significantly higher than of the VADT group (40.0%, P<0.05). In VTD treatment, response was 77.8% in newly diagnosed group and 40.9% in relapsed/refractory group (P<0.01). The rate of response did not differ between VTD and VADT treatments among relapsed/refractory MM patients (P>0.05), but was higher with VTD treatment than with VADT treatment for newly diagnosed MM patients (77.8% vs 36.0%, P<0.05). There was no statistical significance between light chain patients and non-light chain patients in VTD group(P>0.05). The adverse effects of VTD were mainly gastrointestinal symptoms infection, peripheral neuropathy and thrombocytopenia.       Conclusion      VTD treatment is associated with higher rate of remission in treatment of MM, and therefore can be used as a first-line option for newly diagnosed and relapsed/refractory patients.

参考文献/References:

李佳丽, 刘耀, 曾东风, 等. 硼替佐米联合地塞米松和沙利度胺治疗多发性骨髓瘤的临床研究[J]. 第三军医大学学报,2012,34(24):2515-2517.

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更新日期/Last Update: 2012-12-19