[1]刘嘉,高蕾,张曦,等.异基因造血干细胞移植联合伊马替尼治疗成人Ph+急性淋巴细胞白血病临床观察[J].第三军医大学学报,2012,34(24):2453-2455.
 Liu Jia,Gao Lei,Zhang Xi,et al.Clinical efficiency of allogenic hematopoietic stem cell transplantation combined with imatinib in treatment of Philadelphia positive acute lymphoblastic leukemia[J].J Third Mil Med Univ,2012,34(24):2453-2455.
点击复制

异基因造血干细胞移植联合伊马替尼治疗成人Ph+急性淋巴细胞白血病临床观察(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第24期
页码:
2453-2455
栏目:
论著
出版日期:
2012-12-30

文章信息/Info

Title:
Clinical efficiency of allogenic hematopoietic stem cell transplantation combined with imatinib in treatment of Philadelphia positive acute lymphoblastic leukemia
作者:
刘嘉高蕾张曦陈幸华高力李云龙文钦
第三军医大学新桥医院血液科,全军血液病中心
Author(s):
Liu Jia Gao Lei Zhang Xi Chen Xinghua Gao Li Li Yunlong Wen Qin
Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
异基因造血干细胞移植伊马替尼Ph+急性淋巴细胞白血病
Keywords:
hematopoietic stem cell transplantation imatinib Philadelphia positive acute lymphoblastic leukemia
分类号:
R617;R733.71;R979.1
文献标志码:
A
摘要:
目的      观察异基因造血干细胞移植(allogenic hematopoietic stem- cell transplantation,allo-HSCT)联合伊马替尼治疗成人Ph+急性淋巴细胞白血病的效果。      方法      2008年3月至2010年3月,我科对20例成人Ph+急性淋巴细胞白血病患者采用异基因造血干细胞移植联合伊马替尼方案,其中9例接受同胞间HLA全相合移植,6例接受同胞间HLA单倍型移植,3例接受非血缘关系HLA全相合移植,2例接受非血缘关系HLA半全相合移植。20例患者在明确诊断后开始予化疗联合伊马替尼治疗,移植前2周至移植造血重建前停用伊马替尼,造血功能稳定后继续予伊马替尼维持治疗,移植后应用RT-PCR和FISH方法监测BCR/ABL表达水平。      结果      20例患者均成功植入,均未出现严重的移植相关并发症。移植前20例患者接受伊马替尼联合化疗均达到完全缓解(complete remission,CR),BCR/ABL均转为阴性。随访至2012年3月,20例患者中15例骨髓持续CR,BCR/ABL持续阴性,5例复发。      结论      异基因造血干细胞移植联合伊马替尼是治疗Ph+急性淋巴细胞白血病的有效方法。
Abstract:
Objective      To determine the effect of allogenic hematopoietic stem cell transplantation (Allo-HSCT) combined with imatinib on Philadelphia positive acute lymphoblastic leukemia (ALL).       Methods      Twenty Philadelphia positive ALL patients received Allo-HSCT combined with imatinib in our department from March 2008 to March 2010. There were HLA-identical sibling HSCT in 9 cases, HLA-haplotype sibling HSCT in 6 cases, HLA-identical unrelated HSCT in 3 cases, and HLA-mismatched unrelated HSCT in 2 cases. All patients were given the treatment of chemotherapy combined with imatinib after diagnosis. In 2 weeks before transplantation to hematopoietic reconstitution, imatinib was stopped to administer. After hematopoietic function was stabilized, treatment of imatinib was continued. The level of BCR/ABL mRNA was monitored using real-time PCR and fluorescence in situ hybridization (FISH). The last follow-up was carried out in March 2012.       Results      Chemotherapy combined with imatinib treatment resulted in complete response in all 20 patients before HSCT. The level of BCR/ABL mRNA was declined and reached to zero level. All 20 patients achieved stable engraftments without severe transplantation related complications. Until March 2012, 15 of the 20 patients’ bone marrow continued CR, and BCR/ABL fusion gene continued negative, and 5 of the 20 patients relapsed.       Conclusion      Allo-HSCT combined with imatinib is an effective regimen for Philadelphia positive ALL.

参考文献/References:

刘嘉, 高蕾, 张曦, 等. 异基因造血干细胞移植联合伊马替尼治疗成人Ph+急性淋巴细胞白血病临床观察[J]. 第三军医大学学报,2012,34(24):2453-2455.

相似文献/References:

[1]陈姝,李文,罗云,等.减低剂量Bu+Cy预处理方案进行异基因造血干细胞移植治疗白血病的效果观察[J].第三军医大学学报,2012,34(24):2442.
 Chen Shu,Li Wen,Luo Yun,et al.Therapeutic effect of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimen of Bu+Cy for leukemia[J].J Third Mil Med Univ,2012,34(24):2442.
[2]苏毅,赖思含,易海,等.异基因造血干细胞移植术治疗自体造血干细胞移植术后复发的恶性淋巴瘤17例效果分析[J].第三军医大学学报,2012,34(24):2456.
 Su Yi,Lai Sihan,Yi Hai,et al.Allogeneic hematopoietic stem cell transplantation for recurrent lymphoma after autologous stem cell transplantation: clinical analysis of 17 cases[J].J Third Mil Med Univ,2012,34(24):2456.
[3]唐仕明,何大朋,王忠,等.抑制Kit信号通路对豚鼠膀胱间质细胞增殖及自主节律性运动的影响[J].第三军医大学学报,2007,29(23):2264.
 TANG Shi-ming,HE Da-peng,WANG Zhong,et al.Effects of inhibiting Kit signal pathway on proliferation and spontaneous rhythmic motility of interstitial cells in bladder of guinea pigs[J].J Third Mil Med Univ,2007,29(24):2264.
[4]梁雪,陈幸华,孔佩艳,等.异基因造血干细胞移植后肠道移植物抗宿主病临床分析[J].第三军医大学学报,2009,31(21):2158.
[5]颜红菊,唐伦,高蕾,等.单倍体与同胞全相合造血干细胞移植治疗高危急性淋巴细胞白血病疗效观察[J].第三军医大学学报,2016,38(12):1340.
 Yan Hongju,Tang Lun,Gao Lei,et al.Efficacy of haploid-matched vs sibling-matched allogeneic stem cell transplantation for high risk acute lymphoblastic leukemia[J].J Third Mil Med Univ,2016,38(24):1340.
[6]王晓果,陈婷,刘焕凤,等.小剂量地西他滨在异基因造血干细胞移植后早期复发及cGVHD治疗中的作用[J].第三军医大学学报,2016,38(12):1362.
 Wang Xiaoguo,Chen Ting,Liu Huanfeng,et al.Role of small-dose decitabine in treatment of early recurrence and chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation[J].J Third Mil Med Univ,2016,38(24):1362.
[7]韩鹃,梅峰,乔着意,等.Kit信号通路调控成年小鼠Cajal间质细胞的表型改变[J].第三军医大学学报,2014,36(12):1268.
 Han Juan,Mei Feng,Qiao Zhuoyi,et al.Kit signaling regulates phenotype of interstitial cells of Cajal in adult mice[J].J Third Mil Med Univ,2014,36(24):1268.
[8]李明,席亚明,张豪,等.过量误服甲磺酸伊马替尼治疗慢性粒细胞白血病达到遗传学缓解1例[J].第三军医大学学报,2011,33(07):718.
[9]胡聪,李攀,王志刚,等.靶向抗ICAM-1的载伊马替尼和液态氟碳脂质体对内毒素诱导的急性肺损伤/急性呼吸窘迫综合征模型小鼠的治疗研究[J].第三军医大学学报,2018,40(15):1357.
 HU Cong,LI Pan,WANG Zhigang,et al.Anti-ICAM targeted liposomes loaded with imatinib and liquid fluorocarbon treat ALI/ARDS mouse model induced by LPS[J].J Third Mil Med Univ,2018,40(24):1357.
[10]刘红云,陈果,曾韫璟,等.脐带间充质细胞对异基因造血干细胞移植术后出血性膀胱炎的疗效及安全性分析[J].第三军医大学学报,2019,41(23):2296.
 LIU Hongyun,CHEN Guo,ZENG Yunjing,et al.Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation[J].J Third Mil Med Univ,2019,41(24):2296.

更新日期/Last Update: 2012-12-19