[1]莫海兰,李洁,杨智玲,等.CIP2A在喉癌组织中的表达及其临床意义[J].陆军军医大学学报(原第三军医大学学报),2012,34(16):1663-1667.
　Mo Hailan,Li Jie,Yang Zhiling,et al.Expression of CIP2A in laryngeal squamous cell carcinoma and its clinical significance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(16):1663-1667.
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CIP2A在喉癌组织中的表达及其临床意义(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第16期
页码:
1663-1667
栏目:
论著
出版日期:
2012-08-30

文章信息/Info

Title:
Expression of CIP2A in laryngeal squamous cell carcinoma and its clinical significance
作者:
莫海兰; 李洁; 杨智玲; 李兵
重庆医科大学附属第一医院耳鼻喉科
Author(s):
Mo Hailan;  Li Jie;  Yang Zhiling;  Li Bing
Department of Otolaryngology, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
喉鳞状细胞癌; CIP2A; 免疫组织化学; 生存分析
Keywords:
laryngeal squamous cell carcinoma;  CIP2A;  immunohistochemistry;  survival analysis
分类号:
R363.21；R730.23；R739.65
文献标志码:
A
摘要:
目的      探讨蛋白磷酸酶2A 的癌性抑制因子(cancerous inhibitor of protein phosphatase 2A， CIP2A)在喉癌组织中的表达及其与临床病理特征的关系和对预后的影响。      方法      采用免疫组化方法检测61例喉癌标本（包括40例对应癌旁正常组织），9例不典型增生和8例喉乳头状瘤中CIP2A的表达，结合临床病理资料进行分析。      结果      CIP2A在正常癌旁组织中低表达或不表达，在喉鳞状细胞癌中的表达比在喉乳头状瘤和不典型增生中明显增高（P<0.05）。61例喉癌中，CIP2A阴性表达11例（18.0%），弱阳性13例（21.3%），阳性25例（41.0%），强阳性12例（19.7%）,其阳性程度与喉癌的年龄、性别、吸烟和嗜酒无关（P>0.05），而与肿瘤的分级分期、淋巴转移、组织分化程度和预后相关(P<0.05)。喉癌中CIP2A表达越高，其预后越差，高表达组总生存率和无瘤生存率低于低表达组（P<0.05）。      结论      CIP2A参与喉癌的发生、发展过程，对评估喉癌预后有重要作用，可能成为喉癌治疗的有效分子靶标之一。
Abstract:
Objective      To determine the role of CIP2A in the development and progression of laryngeal squamous cell carcinoma and investigate its clinical significance.       Methods      Expression of CIP2A was examined with immunohistochemistry in 61 tissue samples of pathologically identified laryngeal squamous cell carcinoma and their 40 adjacent normal tissues, 9 atypical hyperplasia and 8 laryngeal papilloma. The relationship between CIP2A with the clinicalpathological characteristics and the effect of CIP2A expression on prognosis were analyzed.       Results      The expression of CIP2A was significantly higher in laryngeal squamous cell carcinoma than atypical hyperplasia and laryngeal papilloma (P<0.05). CIP2A immunoreactivity, tested in 61 laryngeal cancer tissues, was negative in 11 cases (18.0%), weakly positive in 13 cases (21.3%), moderately positive in 25 cases (41.0%), and strongly positive in 12 cases (19.7%). The expression of CIP2A was not related with age, sex, smoking and alcohol assumption. Whereas, there were significant correlations of CIP2A with T stage, clinical stage, lymph node metastasis, and histological differentiation (P<0.05). High CIP2A expression predicted poor survival, and was associated with shorter overall-survival and disease-free survival.       Conclusion      Over-expression of CIP2A might be involved in the development and progression of laryngeal squamous cell carcinoma. CIP2A may serve as a useful prognostic marker and therapeutic target for laryngeal squamous cell carcinoma.

相似文献/References:

[1]周建荣,魏莲枝,李银平,等.不同分化喉鳞状细胞癌蛋白质组差异表达的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(06):519.
　ZHOU Jian-rong,WEI Lian-zhi,LI Yin-ping,et al.Comparative proteomic analysis of differently differentiated human laryngeal squamous cell cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(16):519.
[2]蔡铀庆,朱以钊,袁伯庆,等.喉鳞状细胞癌细胞核DNA含量的研究[J].陆军军医大学学报(原第三军医大学学报),1991,13(01):0.[doi:10.16016/j.1000-5404.1991.01.009 ]
　Cai Youqing,Zhu Yizao,and Yuan Boqing..[J].J Amry Med Univ (J Third Mil Med Univ),1991,13(16):0.[doi:10.16016/j.1000-5404.1991.01.009 ]

更新日期/Last Update: 2012-07-30