[1]张立婷,赵荣荣,陈红,等.HBV-DNA低复制慢性乙肝患者血清HA、LN、PcⅢ、CⅣ水平与肝纤维化病理分期相关性分析[J].第三军医大学学报,2012,34(17):1783-1785.
 Zhang Liting,Zhao Rongrong,Chen Hong,et al.Correlation between serum levels of hyaluronic acid, laminin, procollagen Ⅲ and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA[J].J Third Mil Med Univ,2012,34(17):1783-1785.
点击复制

HBV-DNA低复制慢性乙肝患者血清HA、LN、PcⅢ、CⅣ水平与肝纤维化病理分期相关性分析(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第17期
页码:
1783-1785
栏目:
论著
出版日期:
2012-09-15

文章信息/Info

Title:
Correlation between serum levels of hyaluronic acid, laminin, procollagen  Ⅲ  and collagen Ⅳ and pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA
作者:
张立婷赵荣荣陈红李俊峰
兰州大学第一医院感染科
Author(s):
Zhang Liting Zhao Rongrong Chen Hong Li Junfeng
Department of Infectious Diseases,  First Hospital of Lanzhou University, Lanzhou, Gansu Province, 730000, China
关键词:
慢性乙肝HBV-DNA低复制肝纤维化血清肝纤维化指标
Keywords:
chronic hepatitis B low duplication of HBV-DNA liver fibrosis serum markers of liver fibrosis
分类号:
R512.62; R446.112; R446.8
文献标志码:
A
摘要:
目的      研究HBV-DNA低复制、肝功能基本正常或轻微异常的慢性乙肝患者(chronic hepatitis B,CHB)肝纤维化血清指标与肝组织纤维化程度之间的关系。       方法        选择84例HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者,采用双抗体夹心酶联免疫法检测血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型胶原(PcⅢ)、Ⅳ型胶原(CⅣ)水平,并与其肝组织病理分期进行对比研究。       结果        不同年龄段的HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者其HA、LN、PcⅢ、CⅣ水平均具有显著性差异(P<0.01),血清HA、PcⅢ和CⅣ水平随着肝内纤维化程度的加重而递增,并与肝纤维化程度呈正相关,而LN水平在肝纤维化各期无明显差异,与肝纤维化程度无明显相关性(P>0.05)。       结论        对于不同年龄段的HBV-DNA低复制、肝功基本正常或轻微异常的CHB患者,血清肝纤维化指标可作为反映此类患者肝纤维化程度的参考指标,并对该类患者治疗时期的选择具有一定的指导意义。
Abstract:
Objective        To investigate the correlation between the serum markers and the pathological stage of hepatic fibrosis in chronic hepatitis B patients with low duplication of HBV-DNA and normal or mildly abnormal hepatic function.       Methods        Eighty-four hepatitis B patients with low duplication of HBV-DNA and normal or mildly abnormal hepatic function were enrolled and divided into a young group (age <45 years, n=58) and an old group (age≥45 years, n=26). The serum levels of hyaluronic acid (HA), laminin (LN), procollagen III (Pc III) and collagen IV (C IV) were measured by enzyme-linked immunosorbent assay, and meanwhile liver biopsy was performed to examine the pathological stage (S0-S4) of hepatic fibrosis.       Results        The serum levels of HA, LN, Pc III and C IV were significantly higher in the old group than in the young group (P<0.01). The serum levels of HA, Pc III and C IV increased along with the aggravation of hepatic fibrosis, and they were positively correlated with the pathological stage of hepatic fibrosis (r=0.618, 0.575 and 0.492, respectively; P<0.01). The serum level of LN was not correlated with the degree of hepatic fibrosis (P>0.05).       Conclusion        In hepatitis B patients with low duplication of HBV-DNA and normal or mildly subnormal hepatic function, the serum levels of HA, Pc III and C IV can be used as markers for predicting the pathological stage of hepatic fibrosis.

参考文献/References:

张立婷, 赵荣荣, 陈红, 等. HBV-DNA低复制慢性乙肝患者血清HA、LN、PcⅢ、CⅣ水平与肝纤维化病理分期相关性分析[J].第三军医大学学报,2012,34(17):1783-1785.

相似文献/References:

[1]黄茂萍,钟备,张小玉,等.慢性乙肝HBV-DNA载量对甘利欣降酶疗效的影响[J].第三军医大学学报,2005,27(17):1814.

更新日期/Last Update: 2012-08-31