[1]姚一搏,许民辉,徐伦山,等.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].陆军军医大学学报(原第三军医大学学报),2012,34(18):1881-1883.
　Yao Yibo,Xu Minhui,Xu Lunshan,et al.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(18):1881-1883.
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1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第18期
页码:
1881-1883
栏目:
论著
出版日期:
2012-09-30

文章信息/Info

Title:
Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance
作者:
姚一搏; 许民辉; 徐伦山; 耿明英; 谭勇; 李飞鹏; 沈光建
第三军医大学大坪医院野战外科研究所：神经外科，核磁共振室
Author(s):
Yao Yibo;  Xu Minhui;  Xu Lunshan;  Geng Mingying;  Tan Yong;  Li Feipeng;  Shen Guangjian
Department of Neurosurgy, MRI Room, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, China
关键词:
核磁共振波谱; 伽玛刀; 胶质瘤
Keywords:
MRS;  Gamma Knife;  glioma
分类号:
R445.2;R817.5;R739.41
文献标志码:
A
摘要:
目的      调查1H核磁共振波谱（1H-MRS）引导辅助伽玛刀治疗脑胶质瘤的效果。      方法        选择有明确病理诊断的脑胶质瘤20例，分为常规核磁共振（MRI）定位组和MRI结合核磁共振波谱（MRS）定位组，各10例。常规MRI定位组以肿瘤性增强病灶及周围短T1、长T2区为靶灶范围；MRI+MRS定位组则以肿瘤性增强病灶及周围短T1、长T2区间Cho:NAA指数（CNI）≥1.6者为靶灶范围。以伽玛刀治疗后12个月为终未观察期，统计分析两组治疗结果。       结果       治疗有效者13例（65%），包括常规MRI定位组6例，MRI+MRS定位组7例。10例（50%）患者发生脑水肿，包括常规MRI定位组8例，MRI+MRS定位组2例。统计分析示MRI+MRS定位组靶灶直径、脑水肿发生例数、脑水肿范围较常规MRI定位组明显下降（P<0.05）。      结论       伽玛刀治疗加入MRS因素有助于对脑胶质瘤甄别，减少因盲目扩大治疗范围带来的并发症。
Abstract:
Objective       To investigate the effect of Gamma Knife treatment for glioma with 1H-magnetic resonance spectroscopy (MRS) guidance.       Method       Twenty patients with glioma confirmed by pathological diagnosis were selected and divided into a conventional MRI positioning group and a MRI+MRS positioning group (n=10). The target area of the conventional MRI positioning group was defined as the tumorous-enhanced focus plus the surrounding short T1 and long T2 area, and that of the MRI+MRS positioning group was defined as the tumorous-enhanced focus plus the Cho: NAA index (CNI)≥1.6 area in the surrounding short T1 and long T2 area. The differences of the treatment outcomes were statistically analyzed at 12 months after the Gamma Knife treatment.       Results       Thirteen (65%) of the 20 patients showed effective outcome, including 6 patients from the conventional MRI positioning group and 7 patients from the MRI+MRS positioning group. Brain edema was observed in 10 patients (50%), including 8 patents from the conventional MRI positioning group and 2 patients from the MRI+MRS positioning group. The average maximum diameter of target area, the number of patients with brain edema and the range of brain edema decreased significantly in the MRI+MRS positioning group as compared with the conventional MRI positioning group (P<0.05).       Conclusion       Gamma Knife treatment with 1H-MRS guidance helps distinguish glioma, and can reduce the complications from the blind expansion of treatment area.

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更新日期/Last Update: 2012-09-18