[1]姚一搏,许民辉,徐伦山,等.1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].第三军医大学学报,2012,34(18):1881-1883.
 Yao Yibo,Xu Minhui,Xu Lunshan,et al.Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance[J].J Third Mil Med Univ,2012,34(18):1881-1883.
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1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第18期
页码:
1881-1883
栏目:
论著
出版日期:
2012-09-30

文章信息/Info

Title:
Preliminary observation on the effect of Gamma Knife treatment for 20 glioma patients with 1H-MRS guidance
作者:
姚一搏许民辉徐伦山耿明英谭勇李飞鹏沈光建
第三军医大学大坪医院野战外科研究所:神经外科,核磁共振室
Author(s):
Yao Yibo Xu Minhui Xu Lunshan Geng Mingying Tan Yong Li Feipeng Shen Guangjian
Department of Neurosurgy, MRI Room, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing, 400042, China
关键词:
核磁共振波谱伽玛刀胶质瘤
Keywords:
MRS Gamma Knife glioma
分类号:
R445.2;R817.5;R739.41
文献标志码:
A
摘要:
目的      调查1H核磁共振波谱(1H-MRS)引导辅助伽玛刀治疗脑胶质瘤的效果。      方法        选择有明确病理诊断的脑胶质瘤20例,分为常规核磁共振(MRI)定位组和MRI结合核磁共振波谱(MRS)定位组,各10例。常规MRI定位组以肿瘤性增强病灶及周围短T1、长T2区为靶灶范围;MRI+MRS定位组则以肿瘤性增强病灶及周围短T1、长T2区间Cho:NAA指数(CNI)≥1.6者为靶灶范围。以伽玛刀治疗后12个月为终未观察期,统计分析两组治疗结果。       结果       治疗有效者13例(65%),包括常规MRI定位组6例,MRI+MRS定位组7例。10例(50%)患者发生脑水肿,包括常规MRI定位组8例,MRI+MRS定位组2例。统计分析示MRI+MRS定位组靶灶直径、脑水肿发生例数、脑水肿范围较常规MRI定位组明显下降(P<0.05)。      结论       伽玛刀治疗加入MRS因素有助于对脑胶质瘤甄别,减少因盲目扩大治疗范围带来的并发症。
Abstract:
Objective       To investigate the effect of Gamma Knife treatment for glioma with 1H-magnetic resonance spectroscopy (MRS) guidance.       Method       Twenty patients with glioma confirmed by pathological diagnosis were selected and divided into a conventional MRI positioning group and a MRI+MRS positioning group (n=10). The target area of the conventional MRI positioning group was defined as the tumorous-enhanced focus plus the surrounding short T1 and long T2 area, and that of the MRI+MRS positioning group was defined as the tumorous-enhanced focus plus the Cho: NAA index (CNI)≥1.6 area in the surrounding short T1 and long T2 area. The differences of the treatment outcomes were statistically analyzed at 12 months after the Gamma Knife treatment.       Results       Thirteen (65%) of the 20 patients showed effective outcome, including 6 patients from the conventional MRI positioning group and 7 patients from the MRI+MRS positioning group. Brain edema was observed in 10 patients (50%), including 8 patents from the conventional MRI positioning group and 2 patients from the MRI+MRS positioning group. The average maximum diameter of target area, the number of patients with brain edema and the range of brain edema decreased significantly in the MRI+MRS positioning group as compared with the conventional MRI positioning group (P<0.05).       Conclusion       Gamma Knife treatment with 1H-MRS guidance helps distinguish glioma, and can reduce the complications from the blind expansion of treatment area.

参考文献/References:

姚一搏, 许民辉, 徐伦山, 等. 1H-MRS引导辅助伽玛刀治疗20例脑胶质瘤的初步观察[J].第三军医大学学报,2012,34(18):1881-1883.

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更新日期/Last Update: 2012-09-18