[1]吴至凤,张雨平,赵聪敏,等.褪黑素作为睡眠诱导剂在儿童睡眠脑电图检查中的应用[J].第三军医大学学报,2012,34(15):1560-1563.
 Wu Zhifeng,Zhang Yuping,Zhao Congmin,et al.Melatonin in recording sleep electroencephalography for uncooperative children[J].J Third Mil Med Univ,2012,34(15):1560-1563.
点击复制

褪黑素作为睡眠诱导剂在儿童睡眠脑电图检查中的应用(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第15期
页码:
1560-1563
栏目:
论著
出版日期:
2012-08-15

文章信息/Info

Title:
Melatonin in recording sleep electroencephalography for uncooperative children
作者:
吴至凤张雨平赵聪敏廖伟哈杜瑶门庆
第三军医大学新桥医院儿科
Author(s):
Wu Zhifeng Zhang Yuping Zhao Congmin Liao Wei Ha Duyao Men Qing
Department of Pediatrics, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
褪黑素水合氯醛睡眠脑电图儿童
Keywords:
melatonin chloral hydrate sleep electroencephalogram children
分类号:
R339.31; R741.044; R977.1
文献标志码:
A
摘要:
目的      对比褪黑素与水合氯醛作为不合作儿童脑电图检查时睡眠诱导剂的效果,探讨安全、对脑电波背景活动影响更小的睡眠诱导方法。      方法        纳入我院2010年1月至2011年9月需EEG检查的不合作患儿,与家长签知情同意书,根据就诊日期的单双日分组,单数入水合氯醛组,双数入褪黑素组。所有病例于临检查前30 min服用褪黑素或水合氯醛合剂,并记录病情诊断、睡眠潜伏期、睡眠持续时间、困倦时间、对脑电波的影响及不良反应。      结果        ①褪黑素成功诱导入睡较水合氯醛低(76.1% vs 89.7%,P<0.05)。②入睡成功的患儿,褪黑素和水合氯醛的入睡潜伏期无明显差异(M-W检验,P>0.05),但褪黑素组的睡眠持续时间和困倦时间较水合氯醛组短(M-W检验,P<0.05)。③水合氯醛影响脑电背景活动β快波活动较褪黑素增多(18.4% vs 6.0%,P<0.05)。④水合氯醛组16例呕吐,1例行走协调不良;褪黑素组4例兴奋,两组均无其他不良反应发生。      结论        褪黑素诱导睡眠的成功率虽较水合氯醛低,但睡眠持续时间和困倦时间较短,脑电快波活动干扰较少,无明显不良反应,可作为睡眠诱导剂的一个选择。
Abstract:
Objective        To compare melatonin with chloral hydrate in inducing sleep in children undergoing electroencephalography (EEG) in order to find a safe drug with no effect on brain wave when inducing sleep for sleep EEG in uncooperative children.       Methods        A total of 206 uncooperative children who undergoing EEG in our hospital during January 2010 to September 2011 were randomly divided into melatonin group (n=109) and chloral hydrate group (n=97) after the approval of Ethics Committee of our hospital and consents of their parents. All the children took melatonin or chloral hydrate in 0.5 h before the examination. The diagnosis, sleep latency, sleep duration, sleepy time, EEG wave background, and medication adverse reactions were recorded and analyzed.       Results        Melatonin successfully induced sleep in 83 cases, accounting for 76.1%, while chloral hydrate in 87 cases, accounting for 89.7% (P<0.05). There was no significant difference in the sleep latency for hypnotized children between the 2 groups, but the sleep duration and sleepy time was shorter in melatonin group than chloral hydrate group (Mann-Whitney test, P<0.05). Chloral hydrate increased β fast wave in 16 cases (18.4%), and melatonin increased β fast wave in 5 cases (6.0%, Mann-Whitney test, P<0.05). There were 16 children in chloral hydrate group having vomiting, 1 child with uncoordinated gait, while only 4 cases in melatonin group were excited. No other adverse reaction was found.       Conclusion        Though the success rate for sleep inducement is lower when using melatonin than chloral hydrate, but melatonin has shorter sleep duration and sleepy time, and less effect on brain waves, and lesser adverse reactions. It is recommended to induce sleep EEG in uncooperative children.

参考文献/References:

吴至凤, 张雨平, 赵聪敏, 等. 褪黑素作为睡眠诱导剂在儿童睡眠脑电图检查中的应用[J].第三军医大学学报,2012,34(15):1560-1563.

相似文献/References:

[1]徐玉生,金伟林,李星辰,等.褪黑素对脊髓损伤大鼠GAP-43表达的影响[J].第三军医大学学报,2013,35(03):270.
[2]张映琦,廖维宏,李应玉,等.褪黑素对匹罗卡品致痫模型鼠行为改变的影响[J].第三军医大学学报,2005,27(06):521.
[3]张映琦,廖维宏.褪黑素在实验性癫痫中的抗惊厥作用[J].第三军医大学学报,2005,27(03):268.
[4]周敏,徐酉华,李晓辉,等.褪黑素对巨核细胞凋亡的影响及作用机制研究[J].第三军医大学学报,2008,30(18):1702.
 ZHOU Min,XU You-hua,LI Xiao-hui,et al.Anti-apoptotic effect of melatonin on CHRF-288-11 cells via AKT and ERK pathways[J].J Third Mil Med Univ,2008,30(15):1702.
[5]葛勤,曹健,黄林清,等.复方褪黑素分散片处方筛选的研究[J].第三军医大学学报,2004,26(17):0.[doi:10.16016/j.1000-5404.2004.17.033 ]
 GE Qin,CAO Jian,HUANG Lin qing,et al.[J].J Third Mil Med Univ,2004,26(15):0.[doi:10.16016/j.1000-5404.2004.17.033 ]
[6]徐海伟,黎海蒂,范晓棠,等.大鼠海马和额叶皮层褪黑素限速酶N-乙酰基转移酶表达与年龄的关系[J].第三军医大学学报,2002,24(08):0.[doi:10.16016/j.1000-5404.2002.08.014 ]
 XU Hai wei,LI Hai di,FAN Xiao tang,et al.[J].J Third Mil Med Univ,2002,24(15):0.[doi:10.16016/j.1000-5404.2002.08.014 ]
[7]徐海伟,黎海蒂,范晓棠,等.长期注射叠氮钠对大鼠学习记忆和海马内褪黑素受体表达的作用[J].第三军医大学学报,2003,25(03):0.[doi:10.16016/j.1000-5404.2003.03.005 ]
 XU Hai wei,LI Hai di,FAN Xiao tang,et al.[J].J Third Mil Med Univ,2003,25(15):0.[doi:10.16016/j.1000-5404.2003.03.005 ]
[8]徐海伟,黎海蒂,范晓棠,等.褪黑素在叠氮钠所致的海马锥体细胞钙超载中的神经保护作用[J].第三军医大学学报,2003,25(03):0.[doi:10.16016/j.1000-5404.2003.03.008 ]
 XU Hai wei,LI Hai di,FAN Xiao tang,et al.[J].J Third Mil Med Univ,2003,25(15):0.[doi:10.16016/j.1000-5404.2003.03.008 ]
[9]吴旋,徐海伟,黎海蒂,等.AANAT基因工程化ES细胞减少APP高表达PC12细胞Aβ的分泌[J].第三军医大学学报,2003,25(03):0.[doi:10.16016/j.1000-5404.2003.03.012 ]
 WU Xuan,XU Hai wei,LI Hai di,et al.[J].J Third Mil Med Univ,2003,25(15):0.[doi:10.16016/j.1000-5404.2003.03.012 ]
[10]崔东斌,徐洁芳.伴有癫痫的色素失禁症一例报告[J].第三军医大学学报,1986,08(增刊):0.[doi:10.16016/j.1000-5404.1986.s1.034 ]

更新日期/Last Update: 2012-07-27