[1]张永,肖颖彬.紫绀型先天性心脏病患儿血清铁及总铁结合力的变化及意义[J].第三军医大学学报,2012,34(10):971-973.
 Zhang Yong,Xiao Yingbin.Changes of serum iron and total iron-binding capacity of infants with cyanotic congenital heart disease[J].J Third Mil Med Univ,2012,34(10):971-973.
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紫绀型先天性心脏病患儿血清铁及总铁结合力的变化及意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第10期
页码:
971-973
栏目:
论著
出版日期:
2012-05-30

文章信息/Info

Title:
Changes of serum iron and total iron-binding capacity of infants with cyanotic congenital heart disease
作者:
张永肖颖彬
第三军医大学新桥医院全军心血管外科中心
Author(s):
Zhang Yong Xiao Yingbin
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
紫绀型先天性心脏病血清铁总铁结合力慢性缺氧
Keywords:
cyanotic congenital heart disease serum iron total iron-binding capacity chronic hypoxia
分类号:
R446.11;R556.304;R725.411
文献标志码:
A
摘要:
目的      检测紫绀型先天性心脏病患儿血红蛋白、平均红细胞压积、血清铁、总铁结合力及心肌组织铁分布的改变,并探讨其意义。      方法      入组2011年5-11月于新桥医院心外科行手术治疗的先天性心脏病患儿22例,其中男性14例,女性8例,紫绀型先天性心脏病患儿10例,非紫绀先天性心脏病患儿12例。以静脉血为标本,送本院检验科检验血红蛋白及平均红细胞压积,以亚铁嗪法检测血清铁及总铁结合力,以术中右室流出道心肌为标本,Perls-DAB法检测心肌组织中铁的分布。      结果      与非紫绀组患儿相比,紫绀组先心病患儿血红蛋白含量及平均红细胞压积都明显升高(P<0.05)。紫绀先天性心脏病患儿血清铁含量明显低于非紫绀患儿[(23.25±4.4)μmol/L vs (31.34±4.2) μmol/L, P<0.01],并伴有总铁结合力的增加[(69.59±5.8)μmol/L vs (52.67±9.2)μmol/L, P<0.01]。紫绀组患儿心肌组织中铁含量明显增加(P<0.01),广泛分布于心肌中。      结论      紫绀先天性心脏病患儿机体处于铁储备相对缺乏状态,而心肌组织内铁含量增加可能为心肌在缺氧环境下的代偿反应。
Abstract:
Objective      To examine the levels of hemoglobin, mean corpuscular volume, serum iron and total iron-binding capacity and the distribution of iron in myocardium of infants with cyanotic congenital heart disease, and to explore the significance.       Methods      A total of 22 infants with cyanotic (n=10) and acyanotic (n=12) congenital heart disease admitted in our hospital from May 2011 to November 2011 were enrolled. Venous blood was collected for the determination of hemoglobin and mean corpuscular volume, and serum iron and total iron-binding capacity were detected by ferrozine method. The right ventricular myocardium collected during operation was prepared for the detection of iron distribution in myocardium by Perls-DAB.       Results      Compared with the infants with acyanotic congenital heart disease, the infants with cyanotic congenital heart disease had higher levels of hemoglobin (P<0.05), mean corpuscular volume (P<0.05) and total iron-binding capacity (69.59±5.8 vs 52.67±9.2 μmol/L, P<0.01), and a lower level of serum iron (23.25±4.4 vs 31.34±4.2 μmol/L, P<0.01). The myocardial iron content was significantly higher and the myocardial iron distribution was more extensive in the infants with cyanotic congenital heart disease than in the infants with acyanotic congenital heart disease (P<0.01).       Conclusion      Chronic hypoxia leads to a relative deficiency of iron storage in infants with cyanotic congenital heart disease, while the increase of iron content in myocardium may be an adaptive response of the heart to chronic hypoxia.

参考文献/References:

张永, 肖颖彬. 紫绀型先天性心脏病患儿血清铁及总铁结合力的变化及意义[J].第三军医大学学报,2012,34(10):971-973.

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 HONG Yi,JIAN Zhao,XIAO Ying-bin.Upregulated autophagy in myocardium of infants with cyanotic congenital heart defects[J].J Third Mil Med Univ,2009,31(10):2351.
[2]左松,高云华,杨成业,等.紫绀型先天性心脏病的超声诊断价值[J].第三军医大学学报,2001,23(04):0.[doi:10.16016/j.1000-5404.2001.04.037 ]
[3]周洋,刘凌曦,唐仕海,等.β链蛋白在慢性缺氧诱导小鼠心肌肥厚中的作用[J].第三军医大学学报,2017,39(16):1637.
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更新日期/Last Update: 2012-05-21