[1]任玉香,吴凤英,蔡惠芬,等.聚焦超声和激光加电凝治疗HPV高危亚型感染的CINⅠ疗效比较[J].第三军医大学学报,2012,34(04):350-353.
 Ren Yuxiang,Wu Fengying,Cai Huifen,et al.Focused ultrasound vs laser coagulation in treatment of cervical intraepithelial neoplasia Ⅰ with high-risk HPV infection: report of 618 cases[J].J Third Mil Med Univ,2012,34(04):350-353.
点击复制

聚焦超声和激光加电凝治疗HPV高危亚型感染的CINⅠ疗效比较(/HTML )
分享到:

《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第04期
页码:
350-353
栏目:
论著
出版日期:
2012-02-28

文章信息/Info

Title:
Focused ultrasound vs laser coagulation in treatment of cervical intraepithelial neoplasia Ⅰ with high-risk HPV infection: report of 618 cases
作者:
任玉香吴凤英蔡惠芬徐惠成
第三军医大学西南医院妇产科
Author(s):
Ren Yuxiang Wu Fengying Cai Huifen Xu Huichen
Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
关键词:
聚焦超声激光 气体电凝术乳头状瘤病毒感染宫颈上皮内瘤样病变
Keywords:
focused ultrasound lasers electrocoagulation papillomavirus infections cervical intraepithelial neoplasia
分类号:
R771.740.5;R454.2;R454.3
文献标志码:
A
摘要:
目的      比较聚焦超声和激光加电凝治疗伴HPV高危亚型感染的CINⅠ的临床疗效。      方法      对618例HPV高危亚型感染的CINⅠ患者按随机数字表法分组,分别接受CZF超声波和激光加电凝治疗,其中聚焦超声组320例,激光加电凝组298例,在治疗前和治疗后6个月进行阴道镜下活检和HPV检测,评价其有效性和安全性。      结果      2组术中出血差异无统计学意义,聚焦超声组术后阴道流血、阴道流液量均显著少于激光加电凝组(P<0.05)。治疗后6个月,聚焦超声组随访300例,292例CINⅠ消退,治愈率97.3%;200例HPV高危亚型感染全部转阴,清除率66.7%,40例部分转阴,有效率80%。激光加电凝组随访290例,CINⅠ治愈280例,治愈率96.6%;185例HPV高危亚型感染全部转阴,清除率63.8%,30例部分转阴,有效率74.1%。2组组间比较,CINⅠ治愈率与HPV清除率差异无统计学意义;2组组内比较,CINⅠ的消退与HPV清除差异均有统计学意义,且均呈正相关(P<0.05,r=0.175 9、0.147 3)。      结论      聚焦超声和激光加电凝治疗对治疗CINⅠ及HPV高危亚型感染的清除均疗效显著且相当,但聚焦超声术后阴道流血及排液更少。
Abstract:
Objective      To evaluate and compare the clinical therapy efficacy of focused ultrasound and laser coagulation in the treatment of cervical intraepithelial neoplasia (CIN) Ⅰ with high-risk subtypes of HPV infection.       Methods      A total of 618 cases of CIN Ⅰwith high-risk types of HPV infection who were treated in our department from April 2006 to April 2010 were prospectively randomized into focused ultrasound group (n=320) and laser power coagulation group (n=298). The effectiveness and safety were evaluated by biopsy and HPV detection before and in 6 months after treatment. Follow-up were carried out in 2, 6 and 12 months after treatment.       Results      There was no significant difference in blood loss between the 2 groups. Postoperative vaginal bleeding and vaginal fluid were significantly lesser in focused ultrasound than in laser coagulation group (P<0.05). In the first 6 months after treatment, among the 300 cases with follow-up out of focused ultrasound group, there were  292 cases of CIN Ⅰ subsided, with a cure rate of 97.3%. And 200 cases had high-risk types of HPV entire negative, with a clearance rate of 66.7%, and 40 cases were partial negative, with an effective rate of 80%. Among the 290 cases of laser coagulation who were followed up, CIN Ⅰ cured in 280 cases, with a cure rate of 96.6%; 185 cases of high-risk types of HPV infection were entire negative, with a clearance rate of 63.8%, and 30 cases were in the partial negative, with an effective rate of 74.1%. There was no significant difference in the cure rate of CIN Ⅰ and the clearance rate of HPV between the 2 groups. Significant correlation was found between the regression of CIN Ⅰand the clearance of HPV in the 2 groups (P<0.05, r=0.175 9 for focused ultrasound group and 0.147 3 for laser coagulation group).       Conclusion      In the clearance of high-risk HPV types and CINⅠ, the effectiveness of focused ultrasound treatment and laser coagulation treatment are very significant and have no significant difference, but the later has less colporrhagia and vaginal discharge after treatment.

参考文献/References:

任玉香, 吴凤英, 蔡惠芬, 等. 聚焦超声和激光加电凝治疗HPV高危亚型感染的CINⅠ疗效比较[J].第三军医大学学报,2012,34(4):350-353.

相似文献/References:

[1]许川山,王志刚,吴士明,等.光动力作用对膀胱癌细胞线粒体相关调控蛋白Bcl-2/Bax表达的影响[J].第三军医大学学报,2005,27(22):2219.
[2]孙信,邓新粮.高强度聚焦超声治疗宫颈上皮内低度瘤样病变临床观察[J].第三军医大学学报,2009,31(07):634.
[3]付爱军,李建民,朱军,等.经皮激光椎间盘减压术治疗极外侧腰椎间盘突出症[J].第三军医大学学报,2010,32(04):403.
[4]陈红江,高明华,李劲松,等.鼻内镜下聚焦超声治疗变应性鼻炎的临床应用[J].第三军医大学学报,2012,34(13):1350.
 Chen Hongjiang,Gao Minghua,Li Jinsong,et al.Focused ultrasound under nasal endoscopy in treatment of perennial allergic rhinitis[J].J Third Mil Med Univ,2012,34(04):1350.
[5]杨育成,郭志辉,郑芳.非剥脱性点阵激光用于手术伤口瘢痕治疗的观察研究[J].第三军医大学学报,2013,35(16):1766.
[6]李晓东,杨建民,王鹏.头面部爆炸伤颜面修复序列化治疗体会[J].第三军医大学学报,2011,33(21):2316.
[7]滕立新.钬激光切除术治疗浅表性膀胱肿瘤的疗效观察[J].第三军医大学学报,2012,34(05):448.
 Teng Lixin.Clinical efficiency of holmium laser resection for superficial bladder tumor[J].J Third Mil Med Univ,2012,34(04):448.
[8]王敬旭,丁祥龙,容明灯,等.激光酸蚀联合纳米管的种植体表面粗化及分析[J].第三军医大学学报,2014,36(18):1895.
 Wang Jingxu,Ding Xianglong,Rong Mingdeng,et al.Analysis on laser and acid treatment of titanium implant with nanotubes[J].J Third Mil Med Univ,2014,36(04):1895.
[9]陈洁,游箭,牟玮,等.经皮激光椎间盘减压术及其护理配合[J].第三军医大学学报,2004,26(20):0.[doi:10.16016/j.1000-5404.2004.20.006 ]
[10]游箭,牟玮,李强,等.经皮激光汽化减压术治疗腰椎间盘突出症的临床应用[J].第三军医大学学报,2004,26(21):0.[doi:10.16016/j.1000-5404.2004.21.019 ]
 YOU Jian,MU Wei,LI Qiang,et al.[J].J Third Mil Med Univ,2004,26(04):0.[doi:10.16016/j.1000-5404.2004.21.019 ]

更新日期/Last Update: 2012-02-21