[1]李志伟,马千里,张巧,等.急性哮喘气道炎症表型与激素治疗反应性的关系[J].第三军医大学学报,2012,34(10):987-990.
 Li Zhiwei,Ma Qianli,Zhang Qiao,et al.Relationship between phenotypes of airway inflammation and responses to corticosteroid treatment in acute asthma[J].J Third Mil Med Univ,2012,34(10):987-990.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第10期
页码:
987-990
栏目:
论著
出版日期:
2012-05-30

文章信息/Info

Title:
Relationship between phenotypes of airway inflammation and responses to corticosteroid treatment in acute asthma
作者:
李志伟马千里张巧曾兰程晓明林科雄王长征
第三军医大学新桥医院全军呼吸内科研究所,全军呼吸病研究重点实验室
Author(s):
Li Zhiwei Ma Qianli Zhang Qiao Zeng Lan Cheng Xiaoming Lin Kexiong Wang Changzheng
Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
诱导痰哮喘急性加重气道炎症激素
Keywords:
induced sputum acute asthma airway inflammation steroid
分类号:
R392.3;R562.25;R977.1
文献标志码:
A
摘要:
目的      研究急性哮喘气道炎症表型与激素治疗反应性的关系。      方法      采用回顾性的方法对85例急性哮喘患者的诱导痰炎症细胞进行分类,并研究了不同气道细胞炎症表型与患者使用全身激素剂量、时间等的关系。      结果      根据患者诱导痰炎症细胞分类的不同,将患者分为4组:嗜酸性细胞组(31.8%,27/85)和中性粒细胞组(30.6%,26/85)、混合细胞组(16.4%,14/85)和寡细胞组(21.2%,18/85)。各组患者在性别和是否吸烟方面无统计学差异,但嗜酸性细胞组患者严重程度与混合细胞组有统计学差异(P<0.05)。 嗜酸性细胞组全身激素使用剂量及时间显著少于寡细胞和混合细胞组(P<0.05)。同期患者使用吸入激素剂量使用吸入激素时间方面,混合细胞组显著多于嗜酸性细胞组(P<0.05)。中性粒细胞组吸入激素剂量显著少于混合细胞组(P<0.05),而嗜酸性细胞组患者住院时间显著少于混合性细胞组(P<0.05)。其余各组间在全身激素使用剂量及时间、吸入激素使用剂量及时间、住院时间比较无统计学差异(P>0.05)。      结论      不同炎症表型对激素的治疗反应性可能存在差异。不同炎症表型对治疗的反应性差异可能给临床带来重要的指导意义。
Abstract:
Objective      To investigate the relationship between the phenotypes of airway inflammation and the responses to corticosteroid treatment in acute asthma.       Methods      The inflammatory cells of the induced sputum obtained from 85 patients with acute asthma were classified, and the relationship between the phenotypes of airway inflammation and the dose of systemic corticosteroid and the treatment time of corticosteroid treatment was retrospectively analyzed in these patients.       Results      According to the classification of the sputum cells, the 85 acute asthmatic patients were divided into four groups including an eosinophil group (31.8%, 27/85), a neutrophil group (30.6%, 26/85), a mixed cell group (16.4%, 14/85) and a pauci-granulocyte group (21.2%, 18/85). There was no significant difference of sex and smoking among the four groups (P>0.05), but the severity of acute asthma of the eosinophil group was significantly different from that of the mixed cell group (P<0.05). The total dose of systemic corticosteroid and the treatment time were significantly less in the eosinophil group than in the mixed cell group and the pauci-granulocyte group (P<0.05), while the total dose of inhaled corticosteroid and the treatment time were significantly more in the mixed cell group than in the eosinophil group (P<0.05). The total dose of inhaled corticosteroid in the mixed cell group was significantly higher than that of the neutrophil group, while the hospitalization time of the mixed cell group was significantly longer than that of the eosinophil group (P<0.05). There was no significant difference of the dose and treatment time of systemic and inhaled corticosteroid and the hospitalization time among the rest of the groups (P>0.05).       Conclusion      Different phenotypes of airway inflammation may have different responses to corticosteroid treatment in acute asthma, which may provide important clinical implications for the treatment of acute asthma.

参考文献/References:

李志伟, 马千里, 张巧, 等. 急性哮喘气道炎症表型与激素治疗反应性的关系[J].第三军医大学学报,2012,34(10):987-990.

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更新日期/Last Update: 2012-05-21