[1]杨华,罗亚文,刘华庆,等.慢性乙型肝炎患者肝组织CXCR3及其配体IP 10表达与肝脏炎症程度、纤维化的相关性研究[J].陆军军医大学学报(原第三军医大学学报),2012,34(03):250-253.
　Yang Hua,Luo Yawen,Liu Huaqing,et al.CXCR3 and IP 10 expression in patients with chronic hepatitis B and their correlation with degree of liver inflammation and hepatic fibrosis[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(03):250-253.
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慢性乙型肝炎患者肝组织CXCR3及其配体IP 10表达与肝脏炎症程度、纤维化的相关性研究(/HTML )
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陆军军医大学学报（原第三军医大学学报）[ISSN:1000-5404/CN:51-1095/R]

卷:
34卷
期数:
2012年第03期
页码:
250-253
栏目:
论著
出版日期:
2012-02-15

文章信息/Info

Title:
CXCR3 and IP 10 expression in patients with chronic hepatitis B and their correlation with degree of liver inflammation and hepatic fibrosis
作者:
杨华; 罗亚文; 刘华庆; 侯文; 李佳
遵义医学院附属医院：病理科，感染科
Author(s):
Yang Hua;  Luo Yawen;  Liu Huaqing;  Hou Wen;  Li Jia
Department of Pathology, Department of Infectious Disease, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou Province, 563003, China
关键词:
慢性乙型肝炎; CXC趋化因子受体3; 干扰素-γ诱导蛋白-10; 肝炎症; 肝纤维化
Keywords:
chronic hepatitis B;  CXCR3;  IP 10;  liver inflammation;  liver fibrosis
分类号:
R512.62; R392.11; R392.3
文献标志码:
A
摘要:
目的      检测CXC趋化因子3（CXC chemokine receptor 3, CXCR3）及配体干扰素-γ诱导蛋白-10（inducing protein-10, IP 10）在慢性乙型肝炎（chronic hepatitis B，CHB）患者肝组织中的表达，探讨其与肝脏炎症及纤维化程度的关系。      方法        对60例CHB患者及20例健康者肝穿病理检查进行炎症分级（G）及纤维化分期（S），其中G2以上定为重度炎症组；免疫组织化学方法检测肝组织CXCR3、IP 10蛋白的表达，并与肝脏炎症分级及纤维化分期进行统计学分析。      结果       60例CHB患者肝组织中CXCR3（2.55±0.90）及IP 10（2.73±0.76）的表达均高于正常对照组（0.70±0.57，0.60±0.50；P<0.01）。随着肝组织炎症及纤维化程度的加重CXCR3、IP 10水平逐渐上升，但在肝纤维化组仅S1、S2组间有显著性差异（P<0.05）； CXCR3、IP 10与CHB炎症及纤维化程度呈正相关（r分别为0.707，0.788，0.624，0.737，P<0.01）。重度炎症组（G3、G4）：在炎症程度相同情况下，不同肝纤维化组间CXCR3、IP 10水平差异不明显。肝组织CXCR3、IP 10水平呈正相关（r=0.675； P<0.01）。      结论        肝组织CXCR3及配体IP 10的表达参与CHB患者肝脏炎症及纤维化形成，但与炎症程度的关系更密切。
Abstract:
Objective      To study expressions of CXC chemokine receptor 3 (CXCR3) and interferon-γ inducing protein-10 (IP 10) in liver tissues of chronic hepatitis B (CHB) patients and to elucidate their correlation with liver inflammation and degree of hepatic fibrosis.       Methods       Sixty CHB patients and twenty healthy volunteers were given liver puncture biopsy. The subjects were classified according to biopsy results of the degree of inflammation (G) and fibrosis staging (S). Inflammation degree that was more than G2 was identified as severe inflammation. Protein expressions of CXCR3 and IP 10 were detected by immunohistochemistry, and their correlation with liver inflammation grade and fibrosis stage was statistically analyzed.       Results       Expre-ssions of CXCR3 (2.55±0.90) and IP 10 (2.73±0.76) in liver tissues of 60 CHB patients were significantly higher than those of the healthy controls (0.70±0.57, 0.60±0.50; P<0.01). As the degree of liver inflammation and fibrosis aggravated, the levels of CXCR3 and IP 10 increased gradually. In liver fibrosis group, however, significant difference only existed between group S1 and S2 (P<0.05). Expressions of CXCR3 and IP 10 were positively correlated with degree of inflammation and fibrosis in CHB (r=0.707, 0.788, 0.624, 0.737, respectively; P<0.01). In severe inflammation groups (G3 and G4), expressions of CXCR3 and IP 10 showed no significant difference among varying degrees of hepatic fibrosis. There was a positive correlation between expression of CXCR3 and IP 10 in liver tissues (r=0.675, P<0.01).       Conclusion       CXCR3 and IP 10 play an important role in the course of liver inflammation and fibrosis in CHB patients, but their correlation with degree of liver inflammation is closer.

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更新日期/Last Update: 2012-02-08