[1]温玉婷,刘伟,杨爱军,等.IL-17和STAT3在结直肠癌组织中的表达及临床意义[J].第三军医大学学报,2011,33(17):1812-1815.
 Wen Yuting,Liu Wei,Yang Aijun,et al.Expression of IL-17 and STAT3 in colorectal cancer tissue and its clinical significance[J].J Third Mil Med Univ,2011,33(17):1812-1815.
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IL-17和STAT3在结直肠癌组织中的表达及临床意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第17期
页码:
1812-1815
栏目:
论著
出版日期:
2011-09-15

文章信息/Info

Title:
Expression of IL-17 and STAT3 in colorectal cancer tissue and its clinical significance
作者:
温玉婷刘伟杨爱军王晨昱李敏王金穗
兰州大学基础医学院病理学研究所;甘肃省新药临床前研究重点实验室;甘肃省人民医院病理科
Author(s):
Wen Yuting Liu Wei Yang Aijun Wang Chenyu Li Min Wang Jinsui
Department of Pathology, Basic Medical College, Lanzhou University, Lanzhou, Gansu Province, 730000;Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, Gansu Province, 730000; Department of Pathology, Gansu Provincial People’s Hospital, Lanzhou, Gansu Province, 730000, China
关键词:
结直肠癌免疫组织化学IL-17STAT3
Keywords:
colorectal cancer immunohistochemistry IL-17 STAT3
分类号:
R735.3+5;R735.3+7;R392.3
文献标志码:
A
摘要:
目的     检测IL-17和STAT3在结直肠癌组织中的表达,探讨其与结直肠癌临床病理特征和肿瘤血管生成的关系。     方法      应用免疫组织化学S-P法检测94例结直肠癌组织和31例正常肠黏膜组织中IL-17、STAT3蛋白的表达,并应用CD34标记微血管计算MVD。     结果      免疫组化结果显示IL-17主要表达在结直肠癌组织中的肿瘤细胞和肠黏膜固有层淋巴细胞胞浆内, 阳性表达率明显高于正常肠黏膜(P<0.01);IL-17的表达与结直肠癌分化程度和Dukes分期有关(P<0.05)。STAT3在结直肠癌组织中的表达显著高于其在正常肠黏膜中的表达(P<0.01),且与肿瘤细胞分化程度、淋巴结转移和Dukes分期有关(P<0.05)。IL-17和STAT3在结直肠癌组织中的表达与MVD有关(P<0.05)。Spearman等级相关分析表明IL-17和STAT3在结直肠癌组织中的表达呈正相关(r=0.251,P=0.015)。     结论      IL-17和STAT3在结直肠癌组织中高表达,可能在结直肠癌的血管生成和肿瘤的发生、发展中起重要的作用。
Abstract:
Objective       To detect the expression of IL-17 and STAT3 in colorectal cancer (CRC) tissue and explore their relation with its clinicopathological features and angiogenesis.      Methods       Expression of IL-17 and STAT3 in 94 CRC tissue samples and 31 normal intestinal mucosa tissue samples was detected by immunohistochemistry SP method and microvessel density (MVD) was counted according to the number of CD34- marked microvessels.      Results       Immunohistochemistry showed that the IL-17 was mainly expressed in cytoplasm and lymphocytes of normal intestinal mucosa tissue samples, and its positive expression rate was significantly higher in CRC tissue samples than in normal intestinal mucosa samples (P<0.01 ). The expression of IL-17 was related with the CRC cell differentiation and Dukes stage (P<0.05 ). The expression level of STAT3 was significantly higher in CRC tissue samples than in its adjacent normal tissue samples ( P<0.01 ), which was related to the CRC cell differentiation, lymphatic metastasis and Dukes stage (P<0.05). The expression of IL-17 and STAT3 in CRC tissue samples was related with MVD (P<0.05). Spearman stage correlation analysis showed that the expression of IL-17 was positively related with that of STAT3 in CRC tissue samples (r=0.251, P=0.015).      Conclusion      Over-expression of IL-17 and STAT3 in CRC tissue may play an important role in the angiogenesis and carcinogenesis of CRC.

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更新日期/Last Update: 2011-09-07