[1]李素芝,蒋亚建,谢本维,等.中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].第三军医大学学报,2011,33(12):1254-1257.
 Li Suzhi,Jiang Yajian,Xie Benwei,et al.Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China[J].J Third Mil Med Univ,2011,33(12):1254-1257.
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中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第12期
页码:
1254-1257
栏目:
论著
出版日期:
2011-06-30

文章信息/Info

Title:
Correlation between polymorphisms of DRB1, -DQA1, and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China
作者:
李素芝蒋亚建谢本维曾晓华杜翔李世学次罗小平措尼珍贡布边马措蒋业贵
西藏军区总医院感染病科;浙江大学医学部临床医学系;中国人民武装警察部队西藏总队医院感染病科;西藏自治区第二人民医院呼吸科;西藏自治区第一人民医院呼吸科;第三军医大学西南医院全军感染病研究所
Author(s):
Li Suzhi Jiang Yajian Xie Benwei Zeng Xiaohua Du Xiang Li Shixue Ci Luo Xiao Pingcuo Ni Zhen Gong Bu Bian Macuo Jiang Yegui
Department of Infectious Diseases, General Hospital of Tibet Military Command, Lhasa, Tibet Autonomous Region, 850007; Department of Clinical Medicine, Medical College, Zhejiang University, Hangzhou, Zhejiang Pro-vince, 310058; Department of Infectious Diseases, Tibet Corps Hospital of Chinese People’s Armed Police Forces, Lhasa, Tibet Autonomous Region, 850000; Department of Respiratory Diseases, Second People’s Hospital, Lhasa,Tibet Autonomous Region, 850000; ......; China
关键词:
肺结核疾病遗传易感性 基因频率 藏族中国
Keywords:
pulmonary tuberculosis genetic susceptibility to disease gene frequency Tibetan nationalityChina
分类号:
R521.02;R195.4;R394
文献标志码:
A
摘要:
目的    探讨HLA-DRB1、-DQA1和-DQB1等位基因多态性与中国藏族人群肺结核易感性之间的关系。    方法    采用聚合酶链反应/序列特异性引物(PCR/SSP)技术对176例中国西藏地区藏族肺结核患者和189例该地区藏族健康人群的HLA-DRB1、-DQA1和-DQB1等位基因多态性进行分析。    结果    HLA-DRB1*0901、-DQA1*0101和-DQB1*0301在肺结核组的等位基因频率明显高于健康对照组,2组相比差异具有统计学意义(17.33% vs 7.94%,χ2=17.185,P=0.000,OR=2.811;25.85% vs 13.76%,χ2=22.382,P=0.000,OR=2.821;35.51% vs 19.58%,χ2=37.329,P=0.000,OR=3.809)。HLA-DRB1*1301/1302、-DQA1*0501在肺结核组的等位基因频率明显低于健康对照组,2组相比差异具有统计学意义(0.85% vs 6.08%,χ2=15.085,P=0.000,OR=0.125;14.49% vs 26.72%,χ2=22.44,P=0.000,OR=0.355)。    结论    HLA-DRB1*0901、-DQA1*0101和-DQB1*0301与肺结核的易感性密切相关,可能是肺结核的易感基因。HLA-DQA1*0301与肺结核的保护性密切相关,可能为肺结核的保护基因。
Abstract:
Objective    To study the correlation between polymorphisms of HLA-DRB1, -DQA1 and -DQB1 alleles and susceptibility to pulmonary tuberculosis in Tibetan population of China.     Methods    HLA-DRB1, -DQA1 and -DQB1 alleles in 176 patients with pulmonary tuberculosis and 189 normal controls were analyzed using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique.     Results    The frequencies of HLA-DRB1*0901, -DQA1*0101 and -DQB1*0301 alleles were significantly higher in pulmonary tuberculosis patients than in normal controls (17.33% vs 7.94%, 25.85% vs 13.76%, 35.51% vs 19.58%, Chi-square=17.185,P=0.000,OR=2.811;Chi-square=22.382,P=0.000,OR=2.821;Chi-square=37.329,P=0.000,OR=3.809), while the frequencies of HLA-DRB1*1301/1302 and -DQA1*0501 alleles were significantly lower in pulmonary tuberculosis patients than in normal controls (0.85% vs 6.08%, 14.49% vs 26.72%, Chi-square=15.085,P=0.000,OR=0.125;Chi-square=22.44,P=0.000,OR=0.355).     Conclusion    HLA-DRB1*0901, -DQA1*0101 and -DQB1*0301 alleles are closely related with the susceptibility to pulmonary tuberculosis and may be the susceptible genes against pulmonary tuberculosis. HLA-DRB1*1301/1302 and -DQA1*0501 alleles are closely related with the protection of pulmonary tuberculosis and may be the protective genes against pulmonary tuberculosis.

参考文献/References:

李素芝, 蒋亚建, 谢本维, 等. 中国藏族人群HLA-DRB1、-DQA1、-DQB1等位基因多态性与肺结核易感性的关联性研究[J].第三军医大学学报,2011,33(12):1254-1257.

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更新日期/Last Update: 2011-05-24