[1]蒋敬荟,瞿平,魏小平,等.儿童代谢综合征患儿血清中炎症因子hs-CRP、IL-6、TNF-α的变化及意义[J].陆军军医大学学报(原第三军医大学学报),2011,33(14):1530-1533.
 Jiang Jinghui,Qu Ping,Wei Xiaoping,et al.Serum hs-CRP, IL-6 and TNF-α levels and their contributions to metabolic syndrome in children[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(14):1530-1533.
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儿童代谢综合征患儿血清中炎症因子hs-CRP、IL-6、TNF-α的变化及意义(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第14期
页码:
1530-1533
栏目:
论著
出版日期:
2011-07-30

文章信息/Info

Title:
Serum hs-CRP, IL-6 and TNF-α levels and their contributions to metabolic syndrome in children
作者:
蒋敬荟瞿平魏小平刘永芳李廷玉刘友学
重庆医科大学附属儿童医院儿童发育疾病研究省部共建教育部重点实验室:儿童营养研究中心,生化仪器室
Author(s):
Jiang Jinghui Qu Ping Wei Xiaoping Liu Yongfang Li Tingyu Liu Youxue
Children’s Nutrition Research Center, Biochemistry & Instrument Analysis, Key Laboratory of Developmental Diseases in Children of Ministry of Education, Children’s Hospital, Chongqing Medical University, Chongqing, 400014, China
关键词:
超重肥胖炎症因子代谢综合征学龄儿童
Keywords:
overweight obesity inflammatory factors metabolic syndrome school-aged children
分类号:
R195.4;R725.89;R392.11
文献标志码:
A
摘要:
目的    了解正常、超重和肥胖儿童中代谢综合征(metabolic syndrome, MS)的流行特征及MS诊断指标异常儿童血清中炎症因子水平的变化及意义。    方法    从重庆市区选取6所小学,用完全随机方法从各年级抽取2个班,对选中班级的所有学生进行体检,共1 941例,依据2004年中国肥胖问题工作组制定的中国学龄儿童青少年超重、肥胖分类标准,筛选出所有肥胖儿童54例,抽取超重儿童77例,正常儿童72例纳入研究对象,再依据修正的Cook儿童MS诊断标准将研究对象分为3组:正常儿童(74例)、异常非MS儿童 (106例)、MS儿童(23例)。常规测量其身高、体质量、腰围、血压,取空腹静脉血检测其空腹胰岛素、血糖和血脂,ELISA方法测定血清中超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。    结果    肥胖儿童中MS的发生率为27.78%(15/54),超重儿童中MS的发生率为10.39%(8/77),正常儿童中没有出现MS,超重和肥胖儿童中MS发生率差异具有统计学意义(P<0.01)。MS儿童血清hs-CRP、IL-6水平[分别为(1.45±1.75)mg/ml、(4.84±0.60)pg/ml]高于异常非MS组[(0.71±1.11)mg/ml、(1.71±1.10)pg/ml],异常非MS组血清hs-CRP、IL-6浓度也显著高于正常儿童组[分别为(0.34±0.60)mg/ml、(1.35±0.70)pg/ml],3组间血清中的TNF-α水平无明显差异(P>0.05)。     结论    随着体质量增加,MS的发生率显著增加,MS诊断阳性指标数量越多血清中的炎症因子hs-CRP、IL-6水平越高,hs-CRP及IL-6是导致MS发生的显著危险因素。
Abstract:
Objective    To study the epidemiological characteristics of metabolic syndrome (MS) in normal, overweight and obese school-aged children, and the change and significance of serum inflammatory factor levels in children with MS diagnostic indexes.     Methods    Six primary schools were randomly selected from the urban districts of Chongqing, China. For grades 2-5, two classes in each grade were randomly selected for this study. A total of 1 941 children were recruited in this study. According to the overweight and obesity criteria recommended by the Group of China Obesity Task Force, all 54 obese children, as well as randomly selected 77 overweight children and 72 normal children, were used as the subjects. We divided these subjects into three groups, i.e., a normal group (n=74) without any MS diagnostic index, a non-MS group (n=106) with 1 or 2 MS diagnostic indexes, and an MS group (n=23) with 3 or more MS diagnostic indexes. The criteria used to diagnose MS were modifications of the National Cholesterol Education Program (NCEP) ATP Ⅲ according to Cook’s criteria. Anthropometric measurement was conducted by professional persons using routine methods. Serum biochemical markers [including triglycerides (TG), high density lipoprotein (HDL), total cholesterol (TC), low density lipoprotein (LDL), glucose, and insulin] were determined by a clinical analyzer (Siemens ADVIA 2400) using standard methods. The serum levels of tumor necrosis factors-α (TNF-α), interleukin-6 (IL-6) and high-sensitivity C reaction protein (hs-CRP) were analyzed using commercial ELISA kits.     Results    The MS rates were 27.78% (15/54), 10.39% (8/77) and 0% (0/72) in the obese, overweight and normal school-aged children, respectively. The MS rates were statistically different between overweight and obese children (P<0.01). The serum levels of hs-CRP and IL-6 (1.45±1.75 mg/ml and 4.84±0.60 pg/ml) in the MS group were significantly higher than those (0.71±1.11 mg/ml and 1.71±1.10 pg/ml) in the non-MS group (P<0.01). The serum levels of hs-CRP and IL-6 in the non-MS group were higher than those (0.34±0.60 mg/ml and 1.35±0.70 pg/ml) in the normal group. There was no significant difference in the serum TNF-α levels among the three groups (P>0.05).     Conclusion    Our results indicate that overweight and/or obesity increase the MS rate in school-aged children. Low-grade inflammation exists in both overweight and obese children, and may increase the MS risk. Increased MS rate in obese children may be due to increased hs-CRP and IL-6 levels. Both hs-CRP and IL-6 as inflammatory factors have potential use for MS prediction.

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更新日期/Last Update: 2011-07-12