[1]梁瑞凯,魏平.普罗布考治疗46例糖尿病肾病的疗效观察[J].陆军军医大学学报(原第三军医大学学报),2011,33(08):849-852.
 Liang Ruikai,Wei Ping.Observation of the therapeutic effect of probucol on 46 cases of diabetic nephropathy[J].J Amry Med Univ (J Third Mil Med Univ),2011,33(08):849-852.
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普罗布考治疗46例糖尿病肾病的疗效观察(/HTML )
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陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第08期
页码:
849-852
栏目:
论著
出版日期:
2011-04-30

文章信息/Info

Title:
Observation of the therapeutic effect of probucol on 46 cases of diabetic nephropathy
作者:
梁瑞凯魏平
第三军医大学西南医院内分泌科
Author(s):
Liang Ruikai Wei Ping
Department of Endo crinology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
关键词:
普罗布考糖尿病肾病尿微量白蛋白24 h尿蛋白定量
Keywords:
probucol diabetic nephropathy microalbuminuria 24-h urine protein
分类号:
R587.205;R692.05;R972.6
文献标志码:
A
摘要:
目的    评估普罗布考(probucol)延缓糖尿病肾病(diabetic nephropathy, DN)进展的疗效。    方法    将102例临床出现白蛋白尿(尿微量白蛋白>1.9 mg/dl)的2型糖尿病患者,在常规药物治疗的基础上,分成普罗布考组(普罗布考500 mg/d, n=51)和对照组(n=51),随访6个月检测患者血压、血脂(TB、TG、LDL-c、HDL-c)、肾功(s-Cr、BUN、cys-c)、尿蛋白(尿微量白蛋白、24 h尿蛋白定量)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、肝功(AST、ALT、GGT)并作统计学分析。    结果    随访期间,普罗布考治疗组失访5例,对照组失访3例。①普罗布考组治疗后血脂(TC、TG、LDL-c)、cys-c、hs-CRP均较治疗前和对照组均明显下降(P<0.05),并且肾功(s-Cr、BUN)、尿微量白蛋白、24 h尿蛋白定量的增加值普罗布考组明显低于对照组(P<0.05)。②在ARB/ACEI类药物(n=48)用药的基础上,普罗布考治疗更能降低患者cys-c、hs-CRP、24 h尿蛋白定量以及尿微量白蛋白增加水平(P<0.05)。    结论    普罗布考可以改善糖尿病肾病患者尿蛋白以及肾功能情况,对DN进展具有延缓作用,若联合使用ARB/ACEI类药物,对糖尿病肾病的防治会产生协同作用。
Abstract:
Objective    To evaluate the therapeutic effect of probucol on delaying the progression of diabetic nephropathy (DN).     Methods    One-hundred-and-two type II diabetes patients with albuminuria (microalbuminuria >1.9 mg/dl) were divided in a probucol group (500 mg/d, n=51) and a control group (n=51) based on the routine drug treatment. A follow-up survey was carried out for 6 months, in which the blood pressure, blood lipid (TC, TG, LDL-C and HDL-c), renal function (s-Cr, BUN and cys-c), urine protein (microalbuminuria and 24 h urine protein), glycosylated hemoglobin (HbA1c), hypersensitive C-reactive protein (hs-CRP), and liver function (AST, ALT and GGT) were detected. Statistical analyses were also conducted.     Results    During the  6-month follow-up, the data of 5 patients of probucol group and 3 patients of control group were lost.  The blood lipid (TC, TG and LDL-c), cys-c and hs-CRP of the probucol group after treatment were significantly lower than those of the probucol group before treatment and the control group (P<0.05). The increases of s-Cr, BUN, microalbuminuria and 24-h urine protein in the probucol group were significantly lower than those in the control group (P<0.05). Based on the administration of angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ARB/ACEI) drugs (n=48), probucol could suppress the increases of cys-c, hs-CRP, microalbuminuria and 24-h urine protein (P<0.05).     Conclusion    Probucol can reduce the urine protein content and improve the renal function of DN patients, thus delaying the progression of DN. Besides, probucol has a synergic effect with ARB/ACEI drugs on the prevention and treatment of DN.

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更新日期/Last Update: 2011-04-13