[1]李蕊,刘斌,梅耀宇,等.新辅助化疗对早期巨块型宫颈癌淋巴结转移及生存的意义[J].第三军医大学学报,2011,33(12):1289-1292.
 Li Rui,Liu Bin,Mei Yaoyu,et al.Significance of neoadjuvant chemotherapy for lymphatic metastasis and survival in patients with early bulky cervical cancer[J].J Third Mil Med Univ,2011,33(12):1289-1292.
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新辅助化疗对早期巨块型宫颈癌淋巴结转移及生存的意义(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第12期
页码:
1289-1292
栏目:
论著
出版日期:
2011-06-30

文章信息/Info

Title:
Significance of neoadjuvant chemotherapy for lymphatic metastasis and survival in patients with early bulky cervical cancer
作者:
李蕊刘斌梅耀宇令狐华
重庆医科大学附属第一医院妇产科
Author(s):
Li Rui Liu Bin Mei Yaoyu Linghu Hua
Department of Obstetrics and Gynecology, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
宫颈癌新辅助化疗淋巴结转移生存率
Keywords:
cervical cancer neoadjuvant chemotherapy pelvic node metastasis survival
分类号:
R73-37;R730.53;R737.33
文献标志码:
A
摘要:
目的    探讨新辅助化疗(neoadjuvant chemotherapy,NACT)对早期巨块型宫颈癌淋巴结转移及生存的意义。    方法    回顾性分析165例Ⅰb2~Ⅱa期巨块型宫颈癌患者的病例资料并进行随访,根据术前是否行化疗分为NACT组(n=68)和直接手术组(n=97),比较2组淋巴结转移率及生存情况。    结果    NACT及直接手术组发生淋巴结转移的患者转移率差异无统计学意义(13.2% vs 16.5%,P=0.565);但化疗应答者淋巴结转移率则明显低于无应答者(4.8% vs 26.9%, P=0.031)。按阳性淋巴结数目计算,NACT组盆腔淋巴结转移率亦低于直接手术组(1.2% vs 2.8%,P=0.002)。截至随访时间止,淋巴结阳性者5年生存率低于淋巴结阴性者(63.0% vs 86.0%, P=0.252)。NACT组5年生存率高于直接手术组(91.0% vs 77.0%, P=0.274)。对化疗应答者5年生存率高于直接手术组(93.0% vs 87.0%,P=0.145)。    结论    新辅助化疗可以控制宫颈癌淋巴结受累,但对5年生存率及总生存率的影响尚未显示出明显优势。
Abstract:
Objective    To study the significance of neoadjuvant chemotherapy(NACT)for pelvic lymphatic metastasis in patients with early bulky cervical cancer and their survival.     Methods    Clinical data about 165 patients with stage Ⅰb2/Ⅱa bulky cervical cancer were retrospectively analyzed. The patients were divided into NACT group (n=68) and direct operation group (n=97). Lymphatic metastasis and survival rates were compared in the two groups.     Results    No significant difference was found in lymphatic metastasis between the two groups (13.2% vs 16.5%, P=0.565). However, the lymphatic metastasis rate was significantly lower in patients who responded to NACT than in those who did not respond to NACT (4.8% vs 26.9%, P=0.031) while the pelvic lymphatic metastasis rate was lower in NACT group than in direct operation group (1.2% vs 2.8%, P=0.002). By the end of follow-up, the 5-year survival rate was lower in patients with positive lymphatic metastasis than in those with negative lymphatic metastasis (63.0% vs 86.0%, P=0.252) while higher in NACT group than in direct operation group (91% vs 77%, P=0.274) and in patients who responded to NACT than in those who did not respond to NACT (93% vs 87%, P=0.145).     Conclusion    NACT can control the involved lymph nodes in cervical cancer with no significant effect on the 5-year and total survival rates of patients with early bulky cervical cancer.

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更新日期/Last Update: 2011-05-25