[1]王家武,姜庆,樊晓栋.新辅助内分泌联合治疗与单纯根治性手术对前列腺癌预后和疗效的Meta分析[J].第三军医大学学报,2011,33(13):1388-1391.
 Wang Jiawu,Jiang Qing,Fan Xiaodong.Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer: a meta-analysis study[J].J Third Mil Med Univ,2011,33(13):1388-1391.
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新辅助内分泌联合治疗与单纯根治性手术对前列腺癌预后和疗效的Meta分析(/HTML )
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第13期
页码:
1388-1391
栏目:
论著
出版日期:
2011-07-15

文章信息/Info

Title:
Prognosis and efficacy of new adjuvant combination endocrine therapy versus radical surgery for prostate cancer: a meta-analysis study
作者:
王家武姜庆樊晓栋
重庆医科大学附属第二医院泌尿外科
Author(s):
Wang Jiawu Jiang Qing Fan Xiaodong
Department of Urology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China
关键词:
新辅助内分泌治疗前列腺癌Meta分析
Keywords:
neo-adjuvant hormonal therapyprostate cancer meta-analysis
分类号:
R737.25; R730.5; R181.23
文献标志码:
A
摘要:
目的    系统评价新辅助内分泌治疗局限性前列腺癌的有效性。    方法     计算机检索Cochrane图书馆、PubMed、EMBASE、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库。检索时间为1993-2010年。并追查已纳入文献的参考文献。收集有关新辅助内分泌治疗与单纯根治性手术治疗前列腺癌的随机对照研究,并按Cochrane协作网推荐的方法进行系统评价。    结果     共纳入18项研究,4 267例患者。Meta分析结果显示:新辅助内分泌治疗对精囊浸润率无显著改善,但可以改善前列腺癌无生化复发生存率(RR 1.41,95%CI=1.12~1.78, P=0.003),显著降低手术切缘阳性率(RR 0.48, 95%CI=0.43~0.53, P<0.05)、淋巴结转移率(RR 0.64, 95%CI=0.44~0.93, P=0.02)。    结论     新辅助内分泌治疗可以显著降低手术切缘阳性率、淋巴结转移率及前列腺癌无生化复发生存率,但对精囊浸润率无改善。
Abstract:
Objective    To assess the efficacy of neo-adjuvant hormone therapy (NHT) in localized advanced prostate cancer.     Methods     We searched Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database, Chinese Journal Full-text Database (Chinese National Knowledge Infrastructure, CNKI), China Scientific Journal Database (CSJD, VIP database) and Wanfang Database for randomized trials comparing NHT plus radical prostatectomy with radical prostatectomy alone published during 1993 to 2010. Data were extracted and evaluated by two reviewers independently with a designed extraction form recommended by Cochrane, The references in the extracted literature were also retrieved. The RevMan 5.0 software was used for data analysis.     Results     Eighteen randomized trials involving 4 267 patients were included. The results of meta-analyses indicated that NHT prior to prostatectomy did not improve positive seminal vesicles rates, but did significantly improve disease-free survival (RR=1.41, 95% CI 1.12 to 1.78, P=0.003), and significantly reduced positive margin rates (RR=0.48, 95% CI 0.43 to 0.53, P<0.00001), lymph node invasion (RR=0.64, 95% CI 0.44 to 0.93, P=0.02).     Conclusion     NHT plus radical prostatectomy significantly reduces positive margin rates and lymph node invasion and improves disease-free survival rates, but has no effect on positive seminal vesicles rates.

参考文献/References:

王家武, 姜庆, 樊晓栋. 新辅助内分泌联合治疗与单纯根治性手术对前列腺癌预后和疗效的Meta分析[J].第三军医大学学报,2011,33(13):1388-1391.

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更新日期/Last Update: 2011-06-29