[1]张旭升,邹利光,白莉,等.哮喘与慢性阻塞性肺疾病支气管改变的HRCT定量研究[J].第三军医大学学报,2011,33(06):611-614.
 Zhang Xusheng,Zou Liguang,Bai Li,et al.Bronchial changes in asthma and chronic obstructive pulmonary disease: a quantitative study by high resolution computed tomography[J].J Third Mil Med Univ,2011,33(06):611-614.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第06期
页码:
611-614
栏目:
论著
出版日期:
2011-03-30

文章信息/Info

Title:
Bronchial changes in asthma and chronic obstructive pulmonary disease: a quantitative study by high resolution computed tomography
作者:
张旭升邹利光白莉张松王长征梁开运
第三军医大学新桥医院:放射科,全军呼吸内科研究所
Author(s):
Zhang Xusheng Zou Liguang Bai Li Zhang Song Wang Changzheng Liang Kaiyun
Department of Radiology, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China
关键词:
支气管哮喘慢性阻塞性肺疾病高分辨率CT气道重构
Keywords:
bronchial asthma chronic obstructive pulmonary disease high resolution computed tomography airway remodeling
分类号:
R562.25;R563.9;R816.4
文献标志码:
A
摘要:
目的    通过对哮喘和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者胸部高分辨率CT(high resolution computed tomography, HRCT)扫描,探讨哮喘和COPD患者段和亚段支气管重塑的差异。    方法    哮喘34例,COPD 32例,正常对照24例,胸部HRCT扫描,对双上肺尖段及亚段、双下肺后基底段及亚段支气管进行描述性观察和定量分析,采用支气管自动分析软件Thoracic VCAR分别测量4支段和亚段支气管的壁厚度(wall thickness, WT)、腔内径(inner diameter, Din)、壁面积(wall area, WA)和壁面积百分比(WA%),并计算平均值,分析3组间各指标的差异。    结果    哮喘和COPD患者支气管改变表现为支气管壁增厚和管腔变窄。哮喘和COPD患者段支气管各参数的组间比较:WT和WA无统计学差异(P>0.05);哮喘Din小于COPD(P<0.05);哮喘WA%大于COPD(P<0.05)。哮喘和COPD患者亚段支气管各参数的组间比较:哮喘WT、WA 和WA%均小于COPD(P<0.05);哮喘Din大于COPD(P<0.05)。    结论    哮喘和COPD患者有不同程度的支气管重塑,表现为支气管壁增厚和管腔变窄,哮喘患者的气道重构在段和亚段支气管均较明显,COPD患者的气道重构在亚段支气管较明显。
Abstract:
Objective    To investigate the differences of airway remodeling in segmental and sub-segmental bronchi between bronchial asthma and chronic obstructive pulmonary disease (COPD) patients by high resolution computed tomography (HRCT).     Methods    HRCT (120 kV, 80 to 280 mA, 0.6 s) were performed in 34 asthmatic patients, 32 COPD patients and 24 health subjects in our department form April 1, 2009 to July 20, 2010. All these asthmatic patients and COPD patients met the inclusion criteria of the Global Initiative for asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD)  respectively. Image reconstruction was carried out with a 5 mm collimation at 5 mm intervals and 0.625 mm collimation at 0.625 mm intervals respectively. CT images of segmental bronchi and sub-segmental bronchi were reviewed quantitatively and descriptively. Wall thickness (WT), inner diameter (Din), and wall area (WA), percentage of wall area (WA%) of upper lobe apical segmental and sub-segmental bronchi in the right and left lung, as well as in lower lobe posterior basal segmental and sub-segmental bronchi of right and left lung were detected by bronchus automatic analysis software Thoracic VCAR. The mean values of the 4 parameters were calculated and the differences of these parameters between groups were analyzed.     Results    Bronchial wall thickening and luminal narrowing were found in asthma and COPD patients, and bronchiectasis in some cases. The comparison of segmental bronchi parameters between asthma and COPD patients: there was no difference of WA and WA between 2 groups (P>0.05); Din of asthma was smaller than that of COPD (P<0.05); WA% asthma was larger than that of COPD (P<0.05). The comparison of sub-segmental bronchi parameters between 2 groups: WT, WA and WA% of asthma was smaller than those of COPD (P<0.05); Din of asthma was larger than that of COPD (P<0.05).     Conclusion    Bronchial remodeling in asthma and COPD patients manifests as bronchial wall thickening and luminal narrowing. Airway remodeling of asthma patients has both in segmental and sub-segmental bronchi, and airway remodeling of COPD patients is more apparent in sub-segmental bronchi.

参考文献/References:

张旭升, 邹利光, 白莉, 等. 哮喘与慢性阻塞性肺疾病支气管改变的HRCT定量研究[J].第三军医大学学报,2011,33(6):611-614.

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更新日期/Last Update: 2011-03-15