[1]邹海蓉,邹建中,欧霞,等.首次低剂量超声辐照对HIFU消融兔肝VX2瘤的影响[J].第三军医大学学报,2011,33(02):116-118.
　Zou Hairong,Zou Jianzhong,Ou Xia,et al.Effect of firstly low-dose ultrasound irradiation on ablation of rabbit liver VX2 tumor with high intensity focus ultrasound therapy[J].J Third Mil Med Univ,2011,33(02):116-118.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
33卷
期数:
2011年第02期
页码:
116-118
栏目:
论著
出版日期:
2011-01-30

文章信息/Info

Title:
Effect of firstly low-dose ultrasound irradiation on ablation of rabbit liver VX2 tumor with high intensity focus ultrasound therapy
作者:
邹海蓉; 邹建中; 欧霞; 王雁; 张奕
重庆医科大学生物医学工程系，省部共建超声医学工程国家重点实验室，超声医学工程重庆市市级重点实验室
Author(s):
Zou Hairong;  Zou Jianzhong;  Ou Xia;  Wang Yan;  Zhang Yi
State Key Laboratory of Ultrasound Engineering in Medicine Cofounded by Chongqing and Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, Faculty of Biomedical Engineering, Chongqing Medical University, Chongqing， 400016, China
关键词:
高强度聚焦超声; 低剂量超声辐照; 消融; 增效
Keywords:
high intensity focused ultrasound;  firstly low-dose ultrasound irradiation;  ablation;  efficiency
分类号:
R73-354；R730.5；R735.7
文献标志码:
A
摘要:
目的   探讨首次辐照不同低剂量的超声对HIFU消融兔肝VX2瘤的影响。   方法   45只荷瘤兔按随机数字表法分为3组：A组首次辐照功率为0 W，B组80 W，C组100 W；均于第2天接受声功率为180 W的消融治疗。   结果   产生相同的凝固性坏死体积B组所用的时间较A组少（P＜0.05）；B组与C组达到消融坏死的时间无明显差异，但C组所产生的凝固性坏死体积更大（P＜0.05）；3组比较，A组的能效因子（energy efficiency factor, EEF）值（46.43±13.67）最大，C组最小（7.01±1.33, P＜0.05）。   结论   首次低剂量辐照的功率越大，增效作用越明显。
Abstract:
Objective   To investigate the effect of ultrasound irradiation at different low doses on the curative effect of high intensity focus ultrasound (HIFU) on rabbit VX2 liver tumor.    Methods   Forty-five rabbits bearing VX2 tumors at a diameter of 1.2 to 2.2 cm were randomly and equally divided into 3 groups. Group A received only HIFU irradiation (180 W) without firstly low-dose irradiation. Group B and group C both received firstly low-dose irradiation (80 and 100 W respectively) and then received HIFU ablation (180 W) in 24 h later. The tumor mass was observed with light and electron microscopy before and after ablation. TCC staining was used to evaluate the volume of coagulation necrosis and to calculate the energy efficiency factor (EEF).    Results   Group B spent lesser time than group A for the same volume of coagulation necrosis (P<0.05), but group B and C had no significant difference in the time for coagulation necrosis though group C had a larger volume of coagulation necrosis (P<0.05). Compared the 3 groups, the EEF of group A (46.43±13.67) was maximal (P<0.05), and that of group C (7.01±1.33) was minimal (P<0.05).    Conclusion   The greater power of the first irradiation is, the more obvious efficiency will be achieved. However, it is not wise to blindly increase the power of the first irradiation in oreder to guarantee the safety in clinical HIFU therapy.

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更新日期/Last Update: 2011-01-18