[1]张艳伟,胡俊,黎海涛,等.兔严重烧伤早期脑水肿MR弥散成像的实验研究[J].陆军军医大学学报(原第三军医大学学报),2010,32(24):2619-2622.
 Zhang Yanwei,Hu Jun,Li Haitao,et al.MR diffusion imaging of brain edema in rabbits at primary stage of severe burn[J].J Amry Med Univ (J Third Mil Med Univ),2010,32(24):2619-2622.
点击复制

兔严重烧伤早期脑水肿MR弥散成像的实验研究(/HTML )
分享到:

陆军军医大学学报(原第三军医大学学报)[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第24期
页码:
2619-2622
栏目:
论著
出版日期:
2010-12-30

文章信息/Info

Title:
MR diffusion imaging of brain edema in rabbits at primary stage of severe burn
作者:
张艳伟胡俊黎海涛林云陈家飞
第三军医大学西南医院:放射科,神经内科
Author(s):
Zhang Yanwei Hu Jun Li Haitao Lin Yun Chen Jiafei
Department of Radiology, Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
关键词:
烧伤脑水肿 磁共振成像弥散加权成像 弥散张量成像
Keywords:
burn brain edema rabbit magnetic resonance imaging diffusion weighted imaging diffusion tensor imaging
分类号:
R445.2;R644;R742.7
文献标志码:
A
摘要:
目的  探讨兔严重烧伤早期脑水肿发生、发展过程中MR弥散成像改变特征及其诊断价值。  方法  35只健康新西兰大白兔随机数字表法分为对照组及烧伤组(烧伤后1、2、3、4、5、6 h),烧伤组兔均制成50%总烧伤面积Ⅲ度烧伤模型。常规行MRI T1WI、T2WI、DWI、DTI颅脑检查,对各烧伤组和对照组的表观弥散系数(ADC)值、各向异性分数(FA)值,指数表观弥散系数(eADC)值进行动态观察,并用干湿质量法检测其脑含水量的变化。  结果  烧伤后6 h内,T1WI、T2WI像未见明显变化。与对照组相比,烧伤后4~6 h ADC值明显降低(P<0.01),同时eADC值明显增高(P<0.01),而FA值无明显改变。随着观察时间的延长,脑含水量呈逐渐增高趋势,以伤后3~6 h表现最为显著。脑含水量与ADC值(r=-03898,P<0.01)、eADC值(r=03871,P<0.01)的变化呈明显相关性,与FA值无明显相关性(r=03135,P=0.438)。  结论  MR弥散成像能够较好的反映严重烧伤后脑含水量的变化,对烧伤早期明确诊断脑水肿具有重要参考价值。
Abstract:
Objective  To investigate the features of MR diffusion imaging for a rabbit model of severe burn with brain edema at primary stage and its diagnostic value.   Methods  Thirty-five healthy New Zealand white rabbits were equally randomized into 7 groups, control group and burn groups (post-burn at 1, 2, 3, 4 , 5 and 6 h respectively). Severe burn injury was inflicted by 50% total burn surface model with stage III burn. Routine MRI T1WI, T2WI, DWI and DTI with cerebral dynamic observation of apparent diffusion coefficient (ADC), fractional anisotropy (FA) and exponential apparent diffusion coefficient (eADC) values were performed. Changes of cerebral water content were calculated by wet and dry weight method.   Results  No significant change was observed in T1WI and T2WI images within 6 h. Compared with control group, apparent decrease in ADC value (P<0.01) was observed along with significant increase in eADC value (P<0.01), while no significant alteration was seen in FA value(r=0.1). The water content of brain was found to increase with the elapse of time, which reached peak in 3 to 6 h post burn. Significant correlations were found between brain water content with ADC value (r=0.898, P<0.01) and eADC value(r=0.871, P<0.01), however, no correlation was seen with FA value (r=0.135, P=0.438).    Conclusion  MR diffusion image well reflects the change of brain water content post severe burn, and is of significant value in diagnosis of brain edema in primary stage of burn.

相似文献/References:

[1]谭关平,刘浏,何朝晖.大鼠实验性蛛网膜下腔出血后膜铁转运蛋白及铜蓝蛋白的表达[J].陆军军医大学学报(原第三军医大学学报),2015,37(18):1837.
 Tan Guanping,Liu Liu,He Zhaohui.Cerebral expression of Fpn1 and CP in rats after experimental subarachnoid hemorrhage[J].J Amry Med Univ (J Third Mil Med Univ),2015,37(24):1837.
[2]杨勇,王晓娟,刘德贵,等.IL-18增加烧伤休克复苏大鼠中性粒细胞中超氧阴离子的生成[J].陆军军医大学学报(原第三军医大学学报),2012,34(19):1965.
 Yang Yong,Wang Xiaojuan,Liu Degui,et al.IL-18 increases superoxide anion production in neutrophils of rats during resuscitation following burn shock[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(24):1965.
[3]高诗豪,唐政恒,陈图南,等.蜕皮甾酮对大鼠脑组织自由基损伤的保护作用[J].陆军军医大学学报(原第三军医大学学报),2012,34(23):2357.
 Gao Shihao,Tang Zhengheng,Chen Tunan,et al.Ecdysterone protects brain injury against free radical in rats[J].J Amry Med Univ (J Third Mil Med Univ),2012,34(24):2357.
[4]李淑蓉,粟永萍,邓正阳,等.烧伤小鼠早期P56与IFN mRNA表达变化及麻醉或KPV对其表达的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(05):367.
 LI Shu-rong,SU Yong-ping,DENG Zheng-yang,et al.Expressions of P56, IFN-α and IFN-β mRNAs in major organs of severe burn mice and effects of KPV and anaesthesia[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(24):367.
[5]王广,黄跃生,罗中华,等.模拟海上颠簸刺激对严重烧伤家兔心肌力学指标的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):702.
 WANG Guang,HUANG Yue-sheng,LUO Zhong-hua,et al.Effects of simulated toss on myocardial mechanics following early burn injury in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(24):702.
[6]楚燕飞,李兵仓,陈菁,等.水通道蛋白4 RNA干扰对爆炸伤后脑水肿的影响[J].陆军军医大学学报(原第三军医大学学报),2008,30(08):709.
 CHU Yan-fei,LI Bing-cang,CHEN Jing,et al.Effect of aquaporin4 RNAi on brain edema following brain explosive injury[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(24):709.
[7]何梅,覃霞,陈军,等.烧伤患者抑郁情绪障碍发病特点的研究[J].陆军军医大学学报(原第三军医大学学报),2008,30(14):1371.
 HE Mei,QIN Xia,CHEN Jun,et al.Characteristics of depression occurred in burned patients[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(24):1371.
[8]郭晓姝,方海立,李军,等.颈交感神经阻滞对烧伤早期小鼠肝脏干扰素诱导蛋白IFIT1表达的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(17):1647.
 GUO Xiao-shu,FANG Hai-li,LI Jun,et al.Effect of cervical sympathetic block on hepatic interferon-induced protein IFIT1 in burned mice during early stage[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):1647.
[9]陈传莉,刘依凌,王裴,等.严重烧伤后肠黏膜肌球蛋白轻链磷酸化表达改变及其意义[J].陆军军医大学学报(原第三军医大学学报),2008,30(15):1434.
 CHEN Chuan-li,LI Yi-ling,WANG Pei,et al.Role of MLC phosphorylation in intestinal epithelial barrier dysfunction induced by severe burn injury[J].J Amry Med Univ (J Third Mil Med Univ),2008,30(24):1434.
[10]李军,粟永萍,王军平,等.颈交感神经阻滞对小鼠烧伤早期肝组织核因子-κB及其辅活化子的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(08):655.
 LI Jun,SU Yong-ping,WANG Jun-ping,et al.Effect of cervical sympathetic block on hepatic NF-κB and its coactivator during the early stage in burned mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(24):655.
[11]王艺明,杨宗城.去甲肾上腺素对严重烧伤大鼠脑水肿的影响[J].陆军军医大学学报(原第三军医大学学报),2005,27(18):1833.
[12]孙建森,黎海涛,应大君,等.犬严重烧伤早期颅内压动态变化对脑水肿形成的影响[J].陆军军医大学学报(原第三军医大学学报),2004,26(12):0.[doi:10.16016/j.1000-5404.2004.12.028 ]
 SUN Jian sen,LI Hai tao,YING Da jun,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2004,26(24):0.[doi:10.16016/j.1000-5404.2004.12.028 ]
[13]熊加祥,黎海蒂,龚发云,等.严重烧伤影响大鼠脑内c-fos表达和Som-LI与脑水肿的关系[J].陆军军医大学学报(原第三军医大学学报),2002,24(07):0.[doi:10.16016/j.1000-5404.2002.07.004 ]
 XIONG Jia xiang,LI Hai di,Gong Fa yun,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2002,24(24):0.[doi:10.16016/j.1000-5404.2002.07.004 ]
[14]黎海涛,应大君,孙建森,等.犬严重烧伤早期脑水肿MRI与病理对照观察的实验研究[J].陆军军医大学学报(原第三军医大学学报),2000,22(09):0.[doi:10.16016/j.1000-5404.2000.09.013 ]
 LI Hai tao,YING Da jun,SUN Jian sen,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2000,22(24):0.[doi:10.16016/j.1000-5404.2000.09.013 ]
[15]黎海涛,应大君,孙建森,等.TNF在犬严重烧伤早期脑水肿中的变化及意义[J].陆军军医大学学报(原第三军医大学学报),2003,25(06):0.[doi:10.16016/j.1000-5404.2003.06.023 ]
 LI Hai tao,YING Da jun,SUN Jian sen,et al.[J].J Amry Med Univ (J Third Mil Med Univ),2003,25(24):0.[doi:10.16016/j.1000-5404.2003.06.023 ]

更新日期/Last Update: 2010-12-22