[1]赵先英,刘毅敏,肖湘,等.均匀试验设计在利多卡因缓释纳米微球制备中的应用[J].第三军医大学学报,2010,32(21):2300-2302.
 Zhao Xianying,Liu Yimin,Xiao Xiang,et al.Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres[J].J Third Mil Med Univ,2010,32(21):2300-2302.
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《第三军医大学学报》[ISSN:1000-5404/CN:51-1095/R]

卷:
32卷
期数:
2010年第21期
页码:
2300-2302
栏目:
论著
出版日期:
2010-11-15

文章信息/Info

Title:
Applications of uniform design method in preparation of LIDA-PLGA sustained release nanospheres
作者:
赵先英刘毅敏肖湘刘海红粟永萍李明春
第三军医大学:医学检验系暨药学院化学教研室,军事预防医学院防原医学教研室,全军复合伤研究所,创伤、烧伤与复合伤国家重点实验室
Author(s):
Zhao XianyingLiu YiminXiao XiangLi HaihongSu YongpingLi Mingchun
Department  of Chemistry, College of Pharmacy,  State Key Laboratory of Trauma, Burns and Combined Injuries, Department of Nuclear Medicine, Institute of Combined Injury, College of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, China
关键词:
均匀试验设计利多卡因纳米微球包封率微球粒径
Keywords:
uniform design lidocaine nanosphere encapsulation efficiency diameter of microsphere
分类号:
R943; R944.9; R971.2
文献标志码:
A
摘要:
目的    制备利多卡因载药微球,研究制备工艺参数对微球包封率和粒径的影响。    方法     采用均匀试验设计法,以利多卡因(lidocaine, LID)为模型药物,以药物包封率、微球粒径为评价指标,基材及其用量为因素和水平进行U8(85)的实验,得出最佳制备工艺参数。    结果     制备LID-PLGA-Ns的优选条件为:主药与包材基质的质量比为1∶6、内水相的体积比为8∶2、分散剂浓度PVA为3.0%、超声乳化时间为6 min、搅拌速度为2 200(r/min),此时能得到包封率高、平均粒径小的载药微球。    结论     应用均匀试验设计建立的多元二次模型可以较好地预测药微球的基本特性。
Abstract:
Objective    To prepare the lidocaine-loaded nanospheres and study the effect of their pre-paration techniques on their drug encapsulation efficiency (DEE) and mean diameter (MD).     Methods    U8(85)experiments were performed using the uniform design method for basic materials and their volume with the DEE and MD of nanospheres as evaluation indexes and lidocaine as a drug model. Then, optimal preparation technique parameters of nanospheres were detected.     Results    The optimal conditions for preparation of LID-PLGA nanospheres were as follows. The mass ratio of the main drug and its encapsulation substrate was 1∶6, the volume ratio of inner water phase was 8∶2, the concentration of PVA was 3.0%, the phacoemulsification time was 6 min, and the stirring rate was 2 200 r/min.     Conclusion    Multiple secondary model established with uniform design method can rather accurately predict the basic characteristics of drug nanospheres.

参考文献/References:

赵先英, 刘毅敏, 肖湘, 等. 均匀试验设计在利多卡因缓释纳米微球制备中的应用[J].第三军医大学学报,2010,32(21):2300-2302.

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更新日期/Last Update: 2010-11-05